TY - BOOK ID - 33318 TI - Marine Glycosides AU - Adrian, Thomas E AU - Sarabia, Francisco AU - Cheng-Sanchez, Ivan PY - 2019 SN - 9783038979029 9783038979036 DB - DOAB KW - sponge KW - saponins KW - deep-sea KW - Poecillastra compressa KW - Neothyonidium magnum KW - triterpene glycosides KW - magnumosides KW - sea cucumber KW - cytotoxic activity KW - radioactive irradiation KW - sea cucumber KW - Eupentacta fraudatrix KW - triterpene glycoside KW - liquid chromatography–tandem mass spectrometry KW - metabolite profiling KW - holostane KW - nonholostane KW - cucumarioside KW - cytotoxic KW - antifungal KW - glycosides KW - Conus pulicarius KW - steroidal glycoside KW - cholesterol sulfate KW - cytotoxicity KW - leukemia KW - cancer KW - frondoside A KW - tumor growth KW - metastases KW - apoptosis KW - invasion KW - angiogenesis KW - Culcita novaeguineae KW - starfish KW - polyhydroxysteroidal glycoside KW - cytotoxicity KW - mangrove-derived Streptomyces KW - angucycline KW - urdamycin KW - marine organisms KW - carbohydrate KW - glycoside KW - antioxidant KW - anticoagulant KW - anti-inflammatory KW - antitumor KW - antimicrobial KW - glycolipids KW - glycosphingolipids KW - glycoglycerolipids KW - natural products KW - total synthesis KW - triterpene glycosides KW - saponin KW - sea cucumber KW - mass spectrometry KW - MALDI KW - ESI KW - LC-MS KW - Holothuroidea KW - marine ginseng KW - structure elucidation KW - marine invertebrate KW - natural products KW - bioactive compounds KW - antifungal KW - antibacterial KW - antioxidant KW - Streptomyces KW - angucycline glycosides KW - saquayamycin KW - cytotoxicity KW - apoptosis KW - SMMC-7721 UR - https://www.doabooks.org/doab?func=search&query=rid:33318 AB - In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.
The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.
This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones. ER -