TY - BOOK ID - 33715 TI - New Research in Obsessive-Compulsive Disorder and Major Depression AU - Aouizerate, Bruno AU - Haffen, Emmanuel PY - 2019 SN - 9783039210909 / 9783039210916 DB - DOAB KW - OCD KW - tDCS KW - brain stimulation KW - neuromodulation KW - obsession KW - compulsion KW - depression KW - olfaction KW - markers KW - quality of life KW - therapeutic tool KW - transcranial direct current stimulation KW - depression KW - cognition KW - m-health KW - i-health KW - depression KW - nosography KW - categorizations KW - symptoms networks KW - ecological momentary assessment KW - ecological momentary intervention KW - fictional case study KW - psychiatry KW - OCD KW - obsessive–compulsive disorder KW - Tourette syndrome KW - immunology KW - cytokines KW - pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS) KW - pediatric acute-onset neuropsychiatric syndrome (PANS) KW - Toxoplasma gondii KW - Streptococcus pyogenes KW - n/a UR - https://www.doabooks.org/doab?func=search&query=rid:33715 AB - Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD. ER -