TY - BOOK ID - 35937 TI - MicroRNA as Biomarkers in Cancer Diagnostics and Therapy AU - Sempere, Lorenzo F. PY - 2019 SN - 9783039212491 9783039212507 DB - DOAB KW - plasma KW - miRNAs KW - colorectal cancer KW - bevacizumab KW - miRNA KW - biomarker KW - oral cancer KW - leukoplakia KW - early diagnosis KW - liquid biopsy KW - early diagnosis KW - circulating free DNA KW - microRNA KW - hepatocellular carcinoma KW - hepatitis B virus KW - hepatitis C virus KW - long non coding RNA KW - exosomes KW - extracellular microRNA KW - large T-antigen KW - protein-miRNA complex KW - small t-antigen KW - miRNA KW - cancer KW - children KW - leukemia KW - lymphoma KW - review KW - miRNA (microRNA) KW - T-cell acute lymphoblastic leukemia (T-ALL) KW - normalization of miRNA expression in RT-qPCR KW - endogenous controls KW - reference genes KW - tissue analysis KW - cell lines KW - colorectal KW - cancer KW - microRNA KW - biomarkers KW - colorectal cancer KW - confocal slide scanning microscopy KW - inflammation KW - interleukin-1?, microRNA KW - miR-21 KW - TNF-? KW - tumor budding cells KW - n/a UR - https://www.doabooks.org/doab?func=search&query=rid:35937 AB - This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to represent unique microRNA genes in humans, with an increasing number of mechanistic roles identified in developmental, physiological, and pathological processes. Thus, dysregulation of a few key microRNAs can have a profound global effect on the gene expression and molecular programs of a cell. This great potential for clinical intervention has captured the interest and imagination of researchers in many fields. However, very few fields have been as prolific as the field of cancer research. This Special Issue provides but a glimpse of the large body of literature of microRNA biology in cancer research, containing 4 original research studies and 4 review articles that focus on specific hematologic or solid tumors in disease. Collectively, these articles highlight state-of-the-art approaches and methodologies for microRNA detection in tissue, blood, and other body fluids in a range of biomarkers applications, from early cancer detection to prognosis and treatment response. The articles also address some of the challenges regarding clinical implementation. ER -