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Electrospun Nanofibers for Biomedical Applications

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ISBN: 9783039287741 / 9783039287758 Year: Pages: 308 DOI: 10.3390/books978-3-03928-775-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2020-06-09 16:38:57
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Abstract

Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

Keywords

sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- electrospinning --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- electrospinning --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- electrospinning --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- electrospinning --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- electrospinning --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- electrospinning --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- electrospinning --- nanofibers --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-? capture --- human articular chondrocytes --- rheumatoid arthritis --- nanofibers --- microfluidic chip --- electrospinning --- live assay --- hepatocellular carcinoma cells --- PLA95 --- biocompatibility --- guided tissue regeneration (GTR) --- electrospinning --- electrospun fiber mats --- mechanobiology --- glioblastoma --- biomaterials --- finite element modeling --- electrospun nanofibers --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia

Organs-on-chips

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ISBN: 9783039289172 / 9783039289189 Year: Pages: 262 DOI: 10.3390/books978-3-03928-918-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.

Keywords

microfluidics --- vascularization --- organ-on-a-chip --- vascularized tumor model --- tissue engineering --- microfluidic device --- cell culture --- organ-on-chips --- lung epithelial cell --- surfactant protein --- angiogenesis --- shear stress --- biomechanics --- vessel branching --- beating force --- bio-mechanical property --- cardiac 3D tissue --- human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) --- tissue engineering --- vacuum chuck --- barrier permeability --- epithelial–endothelial interface --- paracellular/transcellular transport --- organ-on-chip --- MEMS --- silicon --- PDMS --- membranes --- cell --- strain --- stress --- lattice light-sheet microscopy --- 3D cell culture system --- functional neuron imaging --- 3D cell culture --- neuronal cells --- SH-SY5Y cells --- image-based screening --- nanogrooves --- neuronal cell networks --- neuronal guidance --- drug metabolism --- biomimetic oxidation --- microfluidics --- organ-on-a-chip --- liver-on-a-chip --- liver-on-a-chip --- drug hepatotoxicity --- drug metabolism --- organoid --- 3D cell culture --- spheroid array --- high-throughput screening --- drug efficacy --- organ-on-a-chip (OOC) --- microfluidic device --- mechanical cue --- shear flow --- compression --- stretch --- strain --- syringe pump --- integrated pump --- passive delivery --- organs-on-chips --- microfluidics --- drug absorption --- fluoroelastomer --- ischemia/reperfusion injury --- thrombolysis --- organ-on-a-chip --- endothelial cell activation --- microfluidics --- microfabrication --- organ-on-a-chip --- trans-epithelial electrical resistance --- multi-culture --- n/a

Biomaterials for Bone Tissue Engineering

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ISBN: 9783039289653 / 9783039289660 Year: Pages: 244 DOI: 10.3390/books978-3-03928-966-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Bone tissue engineering aims to develop artificial bone substitutes that partially or totally restore the natural regeneration capability of bone tissue lost under circumstances of injury, significant defects, or diseases such as osteoporosis. In this context, biomaterials are the keystone of the methodology. Biomaterials for bone tissue engineering have evolved from biocompatible materials that mimic the physical and chemical environment of bone tissue to a new generation of materials that actively interacts with the physiological environment, accelerating bone tissue growth. Mathematical modelling and simulation are important tools in the overall methodology. This book presents an overview of the current investigations and recent contributions in the field of bone tissue engineering. It includes several successful examples of multidisciplinary collaboration in this transversal area of research. The book is intended for students, researchers, and professionals of a number of disciplines, such as engineering, mathematics, physics, chemistry, biomedicine, biology, and veterinary. The book is composed of an editorial section and 16 original research papers authored by leading researchers of this discipline from different laboratories across the world

Keywords

Pelvis --- Bone tumor --- 3D-printed implant --- Fixation design --- von Mises stress --- dental implants --- osseointegration --- resonance frequency analysis --- biomaterials --- titanium --- powder metallurgy --- loose sintering --- finite element method --- mechanical behaviour --- bone tissue regeneration --- computed tomography --- Xenografts --- stem cell --- cartilage --- finite element --- finite-element simulation --- electric stimulation --- bone regeneration --- computational modelling --- electrically active implants --- bioelectromagnetism --- critical size defect --- maxillofacial --- minipig --- oxygen delivery --- optimization --- mass transfer --- transport --- bone tissue engineering --- computational fluid dynamics --- Lattice Boltzmann method --- scaffold design --- culturing protocol --- Lagrangian scalar tracking --- cortical bone --- damage --- finite elements --- numerical results --- adipogenesis --- bone marrow --- MSCs --- prediction marker --- bone tissue --- elastoplasticity --- finite element method --- fracture risk --- osteoporosis --- trabeculae --- trabecular bone score --- vertebra --- biomechanics --- finite element modelling --- pelvis --- bone adaptation --- musculoskeletal modelling --- bone tissue engineering --- biomaterials --- computational mechanobiology --- numerical methods in bioengineering --- Ti6Al4V scaffolds --- triply periodic minimal surfaces --- selective laser melting --- additive manufacturing --- biomaterial applications --- finite element analysis --- spark plasma sintering --- wollastonite --- human dental pulp stem cells --- substrate-mediated electrical stimulation --- direct current electric field --- osteo-differentiation --- bone morphogenesis proteins --- cortical bone --- digital image correlation --- multiscale analysis --- micromechanics --- computational mechanics --- cone beam computed tomography --- automatic segmentation --- sliding window --- 3D virtual surgical plan --- Otsu’s method --- n/a

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

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ISBN: 9783039286409 / 9783039286416 Year: Pages: 202 DOI: 10.3390/books978-3-03928-641-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2020-06-09 16:38:57
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Nowadays, we are witnessing highly dynamic research activities related to the intriguing field of biodegradable materials with plastic-like properties. These activities are stimulated by the strengthened public awareness of prevailing ecological issues connected to growing piles of plastic waste and increasing greenhouse gas emissions; this goes hand-in-hand with the ongoing depletion of fossil feedstocks, which are traditionally used to produce full carbon backbone polymers. Polyhydroxyalkanoate (PHA) biopolyesters, a family of plastic-like materials with versatile material properties, are increasing considered to be a future-oriented solution for diminishing these concerns. PHA production is based on renewable resources and occurs in a bio-mediated fashion through the action of living organisms. If accomplished in an optimized way, PHA production and the entire PHA lifecycle are embedded into nature´s closed cycles of carbon. Sustainable and efficient PHA production requires understanding and improvement of all the individual process steps. Holistic improvement of PHA production, applicable on an industrially relevant scale, calls for, inter alia, consolidated knowledge about the enzymatic and genetic particularities of PHA-accumulating organisms, an in-depth understanding of the kinetics of the bioprocess, the selection of appropriate inexpensive fermentation feedstocks, tailoring of PHA composition at the level of its monomeric constituents, optimized biotechnological engineering, and novel strategies for PHA recovery from biomass characterized by low energy and chemical requirements. This Special Issue represents a comprehensive compilation of articles in which these individual aspects have been addressed by globally recognized experts.

Keywords

polyhydroxyalkanoate (PHA), bioprocess design --- carbon dioxide --- cyanobacteria --- upstream processing --- Archaea --- bioeconomy --- biopolyester --- downstream processing --- extremophiles --- haloarchaea --- Haloferax --- halophiles --- polyhydroxyalkanoates --- salinity --- polyhydroxyalkanoates --- terpolymer --- P(3HB-co-3HV-co-4HB) --- Cupriavidus malaysiensis --- polyhydroxyalkanoates --- biomedicine --- biomaterials --- Poly(3-hydroxybutyrate) --- tissue engineering --- wound healing --- delivery system --- poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHVB) --- poly(3-hydroxybutyrate-co-4-hydroxybutyrate) --- bubble column bioreactor --- COMSOL --- microorganism --- PHB --- simulation --- polyhydroxyalkanoate --- PHA --- process analytical technologies --- PAT --- plant oil --- high-cell-density fed-batch --- photon density wave spectroscopy --- PDW --- Ralstonia eutropha --- Cupriavidus necator --- on-line --- in-line --- polyhydroxyalkanoates --- fed-batch --- productivity --- Pseudomonas --- bioreactor --- microaerophilic --- PHA --- viscosity --- non-Newtonian fluid --- fed-batch fermentation --- oxygen transfer --- Pseudomonas putida --- medium-chain-length polyhydroxyalkanoate (mcl-PHA) --- alginate --- biosurfactants --- biopolymer --- Pseudomonas --- blends --- film --- polyhydroxyalkanoates processing --- electrospinning --- additive manufacturing --- selective laser sintering --- fused deposition modeling --- computer-aided wet-spinning --- polyhydroxybutyrate --- tequila bagasse --- hydrolysate detoxification --- activated charcoal --- phenolic compounds --- biomedical application --- cyanobacteria --- feedstocks --- gaseous substrates --- haloarchaea --- high cell density cultivation --- in-line monitoring --- PHA composition --- PHA processing --- polyhydroxyalkanoate --- process engineering --- process simulation --- Pseudomonas sp. --- rheology --- terpolyester --- waste streams

Bio-Based Polymers for Engineered Green Materials

Authors: ---
ISBN: 9783039289257 / 9783039289264 Year: Pages: 568 DOI: 10.3390/books978-3-03928-926-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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With daily signals, Nature is communicating us that its unconscious wicked exploitation is no more sustainable. Our socio-economic system focuses on production increasing without considering the consequences. We are intoxicating ourselves on a daily bases just to allow the system to perpetuate itself. The time to switch into more natural solutions is come and the scientific community is ready to offer more natural product with comparable performance then the market products we are used to deal with. This book collects a broad set of scientific examples in which research groups from all over the world, aim to replace fossil fuel-based solutions with biomass derived materials. In here, some of the most innovative developments in the field of bio-materials are reported considering topics which goes from biomass valorization to the synthesis of high preforming bio-based materials.

Keywords

thermoplastic starch --- corn starch --- chitosan --- crosslinked microparticles --- lignin-containing cellulose nanofibrils --- poly(lactic acid) and composite films --- lignin content --- compatibility --- adsorption --- phenanthrene --- pyrene --- benzoyl cellulose --- stearoyl cellulose --- silkworm cocoons --- dense structure --- porosity --- robust fiber network --- mechanical properties --- photodegradation --- liquid natural rubber --- UV light --- TiO2 anatase --- latex state --- wood modification --- alkali lignin --- water resistance --- dimensional stability --- heat treatment --- polymeric composites --- antifouling --- metal binding --- iron chelation --- polydopamine coating --- free-radical polymerization --- galactoglucomannan --- lignin --- lignin-carbohydrate complex --- ultrafiltration --- precipitation --- hydrogel --- recycling --- thermal degradation --- mechanical degradation --- polylactic acid --- Bioflex --- Solanyl --- PHBV --- poly(lactic acid) --- pulp fibers --- biocomposite --- emulsion-solvent evaporation method --- films --- mechanical properties --- PHA --- mixed microbial cultures --- bioplastics --- feast-famine --- cost --- Peptone --- Microbial nutrient --- Anti-bacterial silver nanoparticle --- Escherichia coli --- Staphylococcus aureus --- tannin --- hemicellulose --- waste biomass --- HSQC-NMR --- pyrolysis mechanism --- hydrotropic treatment --- metal chloride --- delignification --- enzymatic saccharification --- lignocellulosic nanofibrils --- microencapsulated phase change material (MPCM) --- polylactic acid (PLA) --- toughening --- endothermic effect --- kenaf fiber --- hybrid composites --- bio-based --- film --- mechanical properties --- polysaccharides --- resource recovery --- solution casting --- orange waste --- nanocelluloses --- cellulose nanofibers --- cellulose nanocrystals --- bacterial cellulose --- cement --- fiber-cement --- Hatscheck process --- bio-inspired interfaces --- mechanical properties --- thermal stability --- sensitivity --- electrospinning --- tissue engineering --- paper-based scaffolds --- osteoblast proliferation --- polycaprolactone --- biopolymers --- nanoclays --- nanobiocomposites --- extrusion-compounding --- polyhydroxyalkanoates --- thermal properties --- mechanical properties --- differential scanning calorimetry --- nuclear magnetic resonance --- X-ray diffraction --- transparent wood --- chemical composition --- H2O2 bleaching treatment --- physicochemical properties --- cellulose --- electrical resistance --- copper coating --- electroless deposition --- humidity sensor --- strain sensor --- lyocell fiber --- asphalt rubber --- bio-asphalt --- mixing sequence --- workability --- storage stability --- tung oil --- unsaturated polyester resins --- thermosetting polymers --- structure–property relationship --- structural plastics --- ONP fibers --- silanization --- composites --- mechanical properties --- Artemisia vulgaris --- microcellulose fiber --- nanocellulose fibers --- natural fibers --- Bio-based foams --- wastewater treatments --- cationic dyes --- anionic surfactants --- pollutant adsorbents --- tannin polymer --- tannin-furanic foam --- biopolymers --- nanoclays --- bio-nanocomposites --- extrusion-compounding --- polyhydroxyalkanoates --- thermal properties --- microstructure --- volatiles --- autoxidation --- thermal gravimetric analysis --- scanning electron microscope --- headspace solid phase microextraction --- alginate sponge --- two-step lyophilization --- methylene blue --- adsorption capacity --- biomass resources --- hybrid nonisocyanate polyurethane --- solvent- and catalyst-free --- dimer acid --- melt condensation --- bacterial cellulose --- surface modification --- TEMPO oxidation --- one-pot synthesis --- immobilized TEMPO --- physical property --- skincare --- cellulose --- graphene oxide --- ionic liquid --- membrane --- transport properties --- heavy metals --- porous structure --- SAXS --- WAXS --- cellulose --- wood --- lignocellulose --- ionic liquid --- imidazolium --- fractionation --- dissolution --- GC-MS --- kaempferol --- knotwood --- larixol --- taxifolin --- vibrational spectroscopy --- n/a

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eng (5)


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2020 (5)