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The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.

pharmaceutical cocrystal --- melting diagram --- liquid assisted grinding --- adefovir dipivoxil --- dicarboxylic acid --- Crystal structure --- Imidazole --- Benzodioxole --- Semicarbazone --- DFT --- famoxadone --- solvent-mediated polymorphic transformation --- hydrogen-bond-acceptance ability --- crystal structure analysis --- structure determination from powder diffraction data --- salt optimization --- hydrate --- ondansetron --- hygroscopicity --- dehydration --- physicochemical properties --- cocrystal --- solution crystallization --- Raman spectroscopy --- on-line monitoring --- cocrystal formation --- cocrystal --- famotidine --- malonic acid --- crystal structure --- solubility --- hepatitis B --- HBV --- pharmaceutical crystals --- 3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one --- 1H-indole --- pyrimidin-4(3H)-one --- hydrogen bond --- Hirshfeld surface analysis --- molecular docking study --- Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt --- DFT study --- HOMO-LUMO --- reactivity descriptors --- hydrogen bonding --- carbamazepine --- photostability --- polymorphs --- cocrystal --- succinic acid --- saccharin --- ticagrelor --- crystal structure --- crystal habit --- solubility --- dissolution --- n/a

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Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- electrospinning --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- electrospinning --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- electrospinning --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- electrospinning --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- electrospinning --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- electrospinning --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- electrospinning --- nanofibers --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-? capture --- human articular chondrocytes --- rheumatoid arthritis --- nanofibers --- microfluidic chip --- electrospinning --- live assay --- hepatocellular carcinoma cells --- PLA95 --- biocompatibility --- guided tissue regeneration (GTR) --- electrospinning --- electrospun fiber mats --- mechanobiology --- glioblastoma --- biomaterials --- finite element modeling --- electrospun nanofibers --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia