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In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199624 Year: Pages: 268 DOI: 10.3389/978-2-88919-962-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-01-19 14:05:46
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Abstract

The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders.

Contemporary Nostalgia

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ISBN: 9783039215560 9783039215577 Year: Pages: 194 DOI: 10.3390/books978-3-03921-557-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Media and communication
Added to DOAB on : 2019-12-09 11:49:15
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Some of the most pressing contemporary issues (ecological crisis, migration and integration, fragmented worldviews, social media, fake news, extremist politics and terrorism) can be understood more profoundly through how they interact with both individual and collective forces of nostalgia. Nostalgia is politics, but these politics are also interwoven with media and culture. Notwithstanding how nostalgia is used or contextualized in terms of politics and social practices, commodification or personal development, its power is primarily situated within its efficacy as a governing, influential human emotion. The vast and luminous contributions to this special issue on contemporary nostalgia are all investigating the role different aesthetic media formats (film, music, literature, computer games) plays in nostalgic negotiations with style, history, migration, love, nationalism, diaspora, irony, modernity, colonial and postcolonial discourses, and adoption. Mutually, these essays stand out as important, original, critical contributions to the expanding field of nostalgia studies and offer a valued insight on our world.

Keywords

nostalgia --- railways --- modernity --- modernism --- American literature --- heritage cinema --- Hollywood --- reflective nostalgia --- restorative nostalgia --- metanostalgia --- nostalgia --- Lars Gustafsson --- poetry --- tropic reinvention --- landscape --- childhood --- imagery --- expatriation --- nostalgia --- Ian McEwan --- Atonement --- ethics --- responsibility --- nostalgia --- contemporary nostalgia --- nostalgic experience --- nostalgic narrative --- narrative modes --- narrative mediation --- reflective nostalgia --- idealisation --- first-person narrative --- Finland-Swedish literature --- Second World War --- North Africa Campaign --- Egypt --- cosmopolitanism --- imperial nostalgia --- colonial nostalgia --- collective memory --- nostalgia --- ostalgia --- Czech film --- Czech history --- normalisation --- post-communism --- Yugonostalgia --- post-Yugoslav music --- the concept of love --- commodification of feelings and memories --- émigré writers --- lost ideal --- nostalgia --- myths --- popular literature --- nostalgia --- video games --- independent style --- retro aesthetics --- historical recreation --- simulation --- nostalgic dystopias --- F. Scott Fitzgerald --- “The Rich Boy” --- Niklas Salmose --- nostalgia --- nostalgic strategies --- text-image relations --- Red Book Magazine --- F.R. Gruger --- illustrations --- advertisements --- media --- intermediality --- transnational adoption --- nostalgia --- motherhood --- autobiography --- Naumann --- Rickardsson --- nostalgia --- Richard Ford --- pastoral --- southern gothic --- grotesque --- memory --- partition --- nation-state --- Foucault --- heterotopia --- India --- Pakistan --- Partition fiction --- refugees --- Nubia --- nostalgic spaces --- displacement --- territory --- disembodied territoriality --- spatial production --- n/a

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