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Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194810 Year: Pages: 140 DOI: 10.3389/978-2-88919-481-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology --- Medicine (General) --- Internal medicine
Added to DOAB on : 2015-11-16 15:44:59

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Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.

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