Search results: Found 4

Listing 1 - 4 of 4
Sort by
Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

Author:
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452880 Year: Pages: 108 DOI: 10.3389/978-2-88945-288-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2018-02-27 16:16:44
License:

Loading...
Export citation

Choose an application

Abstract

More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Virgil, Aeneid 11 (Pallas & Camilla), 1–224, 498–521, 532–96, 648–89, 725–835. Latin Text, Study Aids with Vocabulary, and Commentary

Author:
ISBN: 9781783746002 / 9781783746026 Year: Pages: 596 DOI: 10.11647/OBP.0158 Language: English
Publisher: Open Book Publishers
Subject: Languages and Literatures
Added to DOAB on : 2019-01-28 13:47:15
License:

Loading...
Export citation

Choose an application

Abstract

A dead boy (Pallas) and the death of a girl (Camilla) loom over the opening and the closing part of the eleventh book of the Aeneid. Following the savage slaughter in Aeneid 10, the book opens in a mournful mood as the warring parties revisit yesterday’s killing fields to attend to their dead. One casualty in particular commands attention: Aeneas’ protégé Pallas, killed and despoiled by Turnus in the previous book. His death plunges his father Evander and his surrogate father Aeneas into heart-rending despair – and helps set up the foundational act of sacrificial brutality that caps the poem, when Aeneas seeks to avenge Pallas by slaying Turnus in wrathful fury. Turnus’ departure from the living is prefigured by that of his ally Camilla, a maiden schooled in the martial arts, who sets the mold for warrior princesses such as Xena and Wonder Woman. In the final third of Aeneid 11, she wreaks havoc not just on the battlefield but on gender stereotypes and the conventions of the epic genre, before she too succumbs to a premature death. In the portions of the book selected for discussion here, Virgil offers some of his most emotive (and disturbing) meditations on the tragic nature of human existence – but also knows how to lighten the mood with a bit of drag.This course book offers the original Latin text, vocabulary aids, study questions, and an extensive commentary. Designed to stretch and stimulate readers, Ingo Gildenhard’s volume will be of particular interest to students of Latin studying for A-Level or on undergraduate courses. It extends beyond detailed linguistic analysis to encourage critical engagement with Virgil’s poetry and the most recent scholarly thought.King's College, Cambridge, has generously contributed to this publication.

Cicero, Philippic 2, 44–50, 78–92, 100–119: Latin Text, Study Aids with Vocabulary, and Commentary

Author:
Book Series: Classics Textbooks ISSN: 20542437 20542445 ISBN: 9781783745890 9781783745913 Year: Volume: 1 Pages: 488 DOI: https://doi.org/10.11647/OBP.0156 Language: English
Publisher: Open Book Publishers
Subject: Languages and Literatures
Added to DOAB on : 2018-09-01 16:05:31
License:

Loading...
Export citation

Choose an application

Abstract

Cicero composed his incendiary Philippics only a few months after Rome was rocked by the brutal assassination of Julius Caesar. In the tumultuous aftermath of Caesar’s death, Cicero and Mark Antony found themselves on opposing sides of an increasingly bitter and dangerous battle for control. Philippic 2 was a weapon in that war.Conceived as Cicero’s response to a verbal attack from Antony in the Senate, Philippic 2 is a rhetorical firework that ranges from abusive references to Antony’s supposedly sordid sex life to a sustained critique of what Cicero saw as Antony’s tyrannical ambitions. Vituperatively brilliant and politically committed, it is both a carefully crafted literary artefact and an explosive example of crisis rhetoric. It ultimately led to Cicero’s own gruesome death.This course book offers a portion of the original Latin text, vocabulary aids, study questions, and an extensive commentary. Designed to stretch and stimulate readers, Ingo Gildenhard’s volume will be of particular interest to students of Latin studying for A-Level or on undergraduate courses. It extends beyond detailed linguistic analysis to encourage critical engagement with Cicero, his oratory, the politics of late-republican Rome, and the transhistorical import of Cicero’s politics of verbal (and physical) violence.

Empirical Analysis of Determinants, Distribution and Dynamics of Poverty

Author:
Book Series: Goettinger Studien zur Entwicklungsoekonomik / Goettingen Studies in Development Economics ISBN: 9783631573983 Year: Pages: 204 DOI: 10.3726/b13880 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Economics --- Political Science
Added to DOAB on : 2019-01-15 13:32:27
License:

Loading...
Export citation

Choose an application

Abstract

Poverty and inequality persist in many dimensions in the developing world. In order to understand the determinants of poverty and its distribution between and within countries, it is necessary to know its dimensions and the channels through which poverty and inequality affect human well-being. This book analyzes the spatial disparities of the outcomes and determinants of poverty, the interdependencies of dimensions of poverty, the distribution of progress in human development over the population and the dynamics of poverty risk over time. The study takes into account the global spread of poverty. Based on cross-country comparisons of countries from Africa, Latin America, and South Asia, this study does not only consider on average outcomes and determinants of different indicators of human well-being, but also examines their distribution between and within countries.

Listing 1 - 4 of 4
Sort by
Narrow your search

Publisher

Open Book Publishers (2)

Frontiers Media SA (1)

Peter Lang International Academic Publishing Group (1)


License

CC by (4)


Language

english (4)


Year
From To Submit

2018 (3)

2017 (1)