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Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book

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Book Series: IDKD Springer Series ISSN: 2523-7829 ISBN: 9783319750187 9783319750194 Year: Pages: 264 DOI: https://doi.org/10.1007/978-3-319-75019-4 Language: English
Publisher: Springer Nature Grant: Foundation for the Advancement of Education in Medical Radiology
Subject: Internal medicine
Added to DOAB on : 2018-06-22 17:34:01
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Abstract

This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.

Keywords

Gastrointestinal disease --- PET/CT --- Radiology --- X-ray --- IDKD --- Davos

Branching and Rooting Out with a CT Scanner: The Why, the How, and the Outcomes, Present and Possibly Future

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197910 Year: Pages: 91 DOI: 10.3389/978-2-88919-791-0 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2017-02-03 17:04:57
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Until recently, a majority of the applications of X-ray computed tomography (CT) scanning in plant sciences remained descriptive; some included a quantification of the plant materials when the root-soil isolation or branch-leaf separation was satisfactory; and a few involved the modeling of plant biology processes or the assessment of treatment or disease effects on plant biomass and structures during growth. In the last decade, repeated CT scanning of the same plants was reported in an increasing number of studies in which moderate doses of X-rays had been used. Besides the general objectives of Frontiers in Plant Science research topics, “Branching and Rooting Out with a CT Scanner” was proposed to meet specific objectives: (i) providing a non-technical update on knowledge about the application of CT scanning technology to plants, starting with the type of CT scanning data collected (CT images vs. CT numbers) and their processing in the graphical and numerical approaches; (ii) drawing the limits of the CT scanning approach, which because it is based on material density can distinguish materials with contrasting or moderately overlapping densities (e.g., branches vs. leaves, roots vs. non-organic soils) but not the others (e.g., roots vs. organic soils); (iii) explaining with a sufficient level of detail the main procedures used for graphical, quantitative and statistical analyses of plant CT scanning data, including fractal complexity measures and statistics appropriate for repeated plant CT scanning, in experiments where the research hypotheses are about biological processes such as light interception by canopies, root disease development and plant growth under stress conditions; (iv) comparing plant CT scanning with an alternative technology that applies to plants, such as the phenomics platforms which target leaf canopies; and (v) providing current and potential users of plant CT scanning with up-to-date information and exhaustive documentation, including clear perspectives and well-defined goals for the future, for them to be even more efficient or most efficient from start in their research work.

In Vivo Imaging in Pharmacological Research

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452378 Year: Pages: 222 DOI: 10.3389/978-2-88945-237-8 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2017-10-13 14:57:01
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The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.

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