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European Union Foreign Policy and the Global Climate Regime

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ISBN: 9782875741349 9783035264098 Year: DOI: 10.3726/978-3-0352-6409-8 Language: English
Publisher: Peter Lang International Academic Publishing Group Grant: Knowledge Unlatched - 103077
Subject: Political Science
Added to DOAB on : 2019-02-15 08:31:14
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This book engages in a longitudinal analysis of the EU’s participation in and impact on the global climate change regime, providing a thought-provoking audit of the potential and limits of the EU’s influence as a foreign policy player in a major domain of global affairs.

A typology of marked-S languages

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Book Series: Studies in Diversity Linguistics ISBN: 9783944675190 Year: Pages: 281 DOI: 10.26530/OAPEN_533871 Language: English
Publisher: Language Science Press
Subject: Linguistics
Added to DOAB on : 2014-09-24 15:01:43
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Case-systems all over the world exhibit striking similarities. In most lan- guages intransitive subjects (S) receives less overt marking than one of the two transitive arguments (agent-like A or patient-like P); the other one of these two arguments is usually encoded by the same form as S. In some languages the amount of overt marking is identical between S, A, and P. But hardly ever does the S argument receive more overt marking than A or P. Yet there are some languages that do not follow this general pattern. This book is about those languages that behave differently, the marked-S languages. Marked-S languages are well-known to be found in East Africa, where they occur in two different language families, Afro-Asiatic and Nilo-Sa- haran. They can also be found in North-Western America and the Pacific region. This book is the first investigation of marked S-languages that treats the phenomenon on a global scale. The study examines the functional distribution of the two main case- forms, the form used for S (S-case) and the case-form of the transitive ar- gument which receives less marking (the zero-case). It offers a very fine- grained perspective considering a wide range of constructions. The con- texts in which the case-marking patterns are investigated include nom- inal, existential and locational predication, subjects in special discourse function (e. g. focused constituents), subjects of passives and dependent clauses, as well as the forms used for addressing someone (vocative form) and for using a noun in isolation (citation form). Apart from the functional distribution of case forms, the formal means of marking are also considered. The main focus is on the synchronic de- scription and comparison of marked-S languages, but historical explana- tions for the unusual case-marking pattern are also discussed.

Chimica farmaceutica: farmaci sistemici: Lezioni del prof. Ettore Novellino

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Book Series: Phármakon ISBN: 9788868870157 Year: Volume: 1 Pages: 767 DOI: 10.6093/978-88-6887-015-7
Publisher: FedOA - Federico II University Press
Subject: Therapeutics
Added to DOAB on : 2018-06-08 13:11:19
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For thousands of years, pharmacological knowledge coming from natural remedies, has been handed down from generation to generation, without any awareness of the ways in which preparations are made to face diseases. The advent of pharmaceutical chemistry and of the modern drug industry turned that lack of awareness into a scientific knowledge that changed the destiny of the human race. The twenty-eight chapters of this book, are taken from the lectures held by Professor Ettore Novellino every year in his course “Pharmaceutical Chemistry and Toxicology 2”. The first chapters address the basic notions of drugs, homeostasis, pharmacopoeia, and receptor; then, the different pharmaceutical classes are introduced by analyzing their pharmacological and chemical aspects. In particular, the structural study of the interaction between drugs and receptors or biological enzymes gives the fundamentals to connect the chemical and stereochemical properties of a compound family, with the biological activity, a correlation better known as Quantitative Structure-Activity Relationship (QSAR). Several examples of the synthesis of some of the most historically renown drugs, provided at the end of each chapter, integrate the book.

European Somalis' Post-Migration Movements

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Book Series: IMISCOE Research Series ISBN: 9783319956602 Year: Pages: 213 DOI: 10.1007/978-3-319-95660-2 Language: English
Publisher: Springer Nature
Subject: Social Sciences --- History --- Migration --- Anthropology
Added to DOAB on : 2020-02-04 11:21:08
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Based on a qualitative study on migrants of Somali origin who have settled in Europe for at least a decade, this open access book offers a ground-breaking exploration of the idea of mobility, both empirically and theoretically. It draws a comprehensive typology of the varied “post-migration mobility practices” developed by these migrants from their country of residence after having settled there. It argues that cross-border mobility may, under certain conditions, become a form of capital that can be employed to pursue advantages in transnational social fields. Anchored in rich empirical data, the book constitutes an innovative and successful attempt at theoretically linking the emerging field of “mobilities studies” with studies of migration, transnationalism and integration. It emphasises how the ability to be mobile may become a significant marker of social differentiation, alongside other social hierarchies. The “mobility capital” accumulated by some migrants is the cornerstone of strategies intended to negotiate inconsistent social positions in transnational social fields, challenging sedentarist and state-centred visions of social inequality. The migrants in the study are able to diversify the geographic and social fields in which they accumulate and circulate resources, and to benefit from this circulation by reinvesting them where they can best be valorised. The study sheds a different light on migrants who are often considered passive or problematic migrants/refugees in Europe, and demonstrates that mobility capital is not the prerogative of highly qualified elites: less privileged migrants also circulate in a globalised world, benefiting from being embedded in transnational social fields and from mobility practices over which they have gained some control. ; This open access book highlights the relevance of various types of cross-border movements in the post-migration lives of women and men of Somali origin Brings together conceptual insights from the migration studies and the mobilities studies to understand migrants' biographies Contributes to an emerging field that aims to trans-nationalize theories of social inequalities

Grammatical theory: From transformational grammar to constraint-based approaches

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Book Series: Textbooks in Language Sciences ISBN: 9783944675213 9783946234296 9783946234401 9783946234302 9783946234418 Year: Pages: 831 DOI: 10.26530/OAPEN_611693 Language: English
Publisher: Language Science Press
Subject: Linguistics
Added to DOAB on : 2016-07-13 11:01:16
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"This book introduces formal grammar theories that play a role in current linguistic theorizing (Phrase Structure Grammar, Transformational Grammar/Government & Binding, Generalized Phrase Structure Grammar, Lexical Functional Grammar, Categorial Grammar, Head-​Driven Phrase Structure Grammar, Construction Grammar, Tree Adjoining Grammar). The key assumptions are explained and it is shown how the respective theory treats arguments and adjuncts, the active/passive alternation, local reorderings, verb placement, and fronting of constituents over long distances. The analyses are explained with German as the object language. The second part of the book compares these approaches with respect to their predictions regarding language acquisition and psycholinguistic plausibility. The nativism hypothesis, which assumes that humans posses genetically determined innate language-specific knowledge, is critically examined and alternative models of language acquisition are discussed. The second part then addresses controversial issues of current theory building such as the question of flat or binary branching structures being more appropriate, the question whether constructions should be treated on the phrasal or the lexical level, and the question whether abstract, non-visible entities should play a role in syntactic analyses. It is shown that the analyses suggested in the respective frameworks are often translatable into each other. The book closes with a chapter showing how properties common to all languages or to certain classes of languages can be captured. The book is a translation of the German book Grammatiktheorie, which was published by Stauffenburg in 2010. "

Antimicrobial Peptides

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ISBN: 9783038420729 9783038420736 Year: Pages: 336 DOI: 10.3390/books978-3-03842-073-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 10:29:38
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Antimicrobial peptides (AMPs) are gene-encoded, ancient (and important) mediators of innate host defense that exert direct or indirect antimicrobial action as well as possessing other important biologic activities (e.g., neutralization of endotoxin and anti-biofilm action) that help to protect vertebrates, invertebrates and plants from invading pathogens. While the emergence of multi-antibiotic resistant pathogens (and the desperate need to develop new anti-infectives) has been a recent force driving the field, interest in AMPs has an earlier origin in studies of how phagocytes kill bacteria by oxygen-independent processes. AMPs responsible for such killing of microbes by rabbit and human neutrophils were later purified by Ganz, Selsted and Lehrer, which they termed defensins; at the time of this writing, literally thousands of defensin-based publications can be found in the scientific literature! The initial reports on defensins and the earlier report by Boman’s group on the purification and action of an insect AMP represented a historical and defining point for the AMP field as they, in hindsight, demanded the recognition of AMP research as a unique discipline that has important linkages to other important fields of medicine, especially those of microbiology, infectious diseases and immunology. On a personal note, I remember conferences on phagocytes and host defense in the early 1980s where the topic of AMPs was relegated to one short session in a five day period! Now, we have hundreds of international “AMPologists” with expertise in chemistry, biochemistry, molecular and structural biology, cell biology, microbiology, pharmacology, or medicine who have built their research careers around AMPs and can now attend international conferences dedicated to advances in AMP research.

Lateralization and cognitive systems

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194117 Year: Pages: 314 DOI: 10.3389/978-2-88919-411-7 Language: English
Publisher: Frontiers Media SA
Subject: Psychology --- Science (General)
Added to DOAB on : 2015-12-10 11:59:06
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Left-right asymmetries of structure and function are a common organization principle in the brains of humans and non-human vertebrates alike. While there are inherently asymmetric systems such as the human language system or the song system of songbirds, the impact of structural or functional asymmetries on perception, cognition and behavior is not necessarily limited to these systems. For example, performance in experimental paradigms that assess executive functions such as inhibition, planning or action monitoring is influenced by information processing in the bottom-up channel. Depending on the type of stimuli used, one hemisphere can be more efficient in processing than the other and these functional cerebral asymmetries have been shown to modulate the efficacy of executive functions via the bottom-up channel. We only begin to understand the complex neuronal mechanisms underlying this interaction between hemispheric asymmetries and cognitive systems. Therefore, it is the aim of this Research Topics to further elucidate how structural or functional hemispheric asymmetries modulate perception, cognition and behavior in the broadest sense.

Protein Phosphorylation in Health and Disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199006 Year: Pages: 122 DOI: 10.3389/978-2-88919-900-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2016-01-19 14:05:46
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Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other.

Extinction Learning from a Mechanistic and Systems Perspective

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199082 Year: Pages: 277 DOI: 10.3389/978-2-88919-908-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Throughout their lifetime, animals learn to associate stimuli with their consequences. Following memory acquisition and consolidation, circumstances may arise that necessitate that initially learned behaviour is no longer relevant. The ensuing process is called extinction learning and involves a novel and complex learning procedure that involves a large number of neural entities. While the neural fundaments of the initial acquisition are well studied, our understanding of the behavioural and neural basis of extinction is still limited and derives mostly from rodent data acquired through fear conditioning paradigms. Fear conditioning and extinction in rodents is a spectacularly successful paradigm within behavioral neuroscience. However, in recent years, new approaches have been emerging that examine the mechanisms of extinction learning in different setting that also involve appetitive models, a broader comparative perspective, a focus on other brain systems, an examination of hormonal factors, and conditioning of immune responses. Only a broader analysis of the neural fundaments of extinction learning will finally uncover shared and distinct mechanisms that underlie extinction learning in different functional systems. The papers compiled in this Research Topic offer new and valuable insights into the mechanisms and functional implementation of extinction learning at its different levels of complexity, and form the basis for new concepts and research ideas in this field.

From Sex Differences in Neuroscience to a Neuroscience of Sex Differences: New Directions and Perspectives

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196890 Year: Pages: 199 DOI: 10.3389/978-2-88919-689-0 Language: English
Publisher: Frontiers Media SA
Subject: Internal medicine --- Medicine (General) --- Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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This research topic aims to integrate scattered findings on sex differences in neuroscience into a broader theory of how the human brain is shaped by sex and sex hormones in order to cause the great variety of sex differences that are commonly observed. It can be assumed that these differences didn’t occur arbitrarily, but that they rather determined and still determine evolutionary success of individuals and were shaped by the processes of natural and in particular sexual selection. Therefore, sex differences are not negligible and sex difference research cannot be discriminating against one sex or the other. In fact a better understanding of the underlying causes of sex differences has great advantages for both men and women and society as a whole, not only in terms of health care, but in every aspect of life. Gender equality can only work out if it is equally well understood for men and women what their individual resources and needs are. Therefore, it is of great importance to pave the way for identifying the underlying principles of structural and functional brain organization that cause men and women to act, think and feel differently. To this end it is of particular interest to identify possible similarities and interrelations between sex differences that did so far stand separately, in order to investigate whether they share a common source. To understand, where a specific sex difference comes from and whether or not it is caused by the same principle as other sex differences, it is necessary to explicitly link sex differences in behavior to their neuronal correlates and vice versa link sex differences in brain structure and function to their behavioral outcomes. In particular a new understanding of male and female brain functioning may arise from findings on how sex hormones interact with various neurotransmitter systems. In the past few years several findings demonstrated that women’s behavior is influenced by the sex hormone fluctuations they experience naturally during their menstrual cycle to the extent that sex differences may only be detectable in one cycle phase but not another. The study of menstrual cycle dependent effects gives important hints about which sex differences are activational and which are organizational. Additionally it only recently came to attention, that hormonal contraception may alter a women’s mood, cognition and behavior as a consequence of changes in brain structure and function. The underlying mechanisms are so poorly understood that it is even hard to predict, whether hormonal contraception will mask or amplify sex differences in a given task. Since the oral hormonal contraceptive pill is meanwhile used by 100 million women worldwide and even by teenagers whose brains are not yet fully developed, the question of how the synthetic steroids contained in hormonal contraceptives act on the brain is to be studied hand in hand with naturally occurring sex differences. This topic summarizes the current state of the art in sex difference research and gives new perspectives in terms of hypothesis generation an methodology. Both are necessary to gain a complete picture of what it is that makes a brain male or female and move towards a neuroscience of sex differences.

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