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Data-Based Radiation Oncology - Design of Clinical Trials

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454389 Year: Pages: 109 DOI: 10.3389/978-2-88945-438-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2018-11-16 17:17:57
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In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients?Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable.In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management.

Women and Migration

Authors: --- ---
ISBN: 9781783745678 Year: Pages: 670 DOI: 10.11647/OBP.0153 Language: English
Publisher: Open Book Publishers
Subject: Social Sciences --- Arts in general
Added to DOAB on : 2019-03-30 11:21:03
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"The essays in this book chart how women’s profound and turbulent experiences of migration have been articulated in writing, photography, art and film. As a whole, the volume gives an impression of a wide range of migratory events from women’s perspectives, covering the Caribbean Diaspora, refugees and slavery through the various lenses of politics and war, love and family. The contributors, which include academics and artists, offer both personal and critical points of view on the artistic and historical repositories of these experiences. Selfies, motherhood, violence and Hollywood all feature in this substantial treasure-trove of women’s joy and suffering, disaster and delight, place, memory and identity. This collection appeals to artists and scholars of the humanities, particularly within the social sciences; though there is much to recommend it to creatives seeking inspiration or counsel on the issue of migratory experiences."

Women and Migration : Responses in Art and History

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ISBN: 9791036538070 Language: English
Publisher: Open Book Publishers
Subject: Social Sciences
Added to DOAB on : 2019-12-06 13:15:40
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The essays in this book chart how women's profound and turbulent experiences of migration have been articulated in writing, photography, art and film. As a whole, the volume gives an impression of a wide range of migratory events from women's perspectives, covering the Caribbean Diaspora, refugees and slavery through the various lenses of politics and war, love and family. The contributors, which include academics and artists, offer both personal and critical points of view on the artistic and historical repositories of these experiences. Selfies, motherhood, violence and Hollywood all feature in this substantial treasure-trove of women's joy and suffering, disaster and delight place, memory and identity. This collection appeals to artists and scholars of the humanities, particularly within the social sciences; though there is much to recommend it to creatives seeking inspiration or counsel on the issue of migratory experiences. As with all Open Book publications, this entire book is available to read for free on the publisher's website. Printed and digital editions, together with supplementary digital material, can also be found here: www.openbookpublishers.com

Whose Book Is it Anyway?: A View from Elsewhere on Publishing, Copyright and Creativity

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ISBN: 9781783746484 9781783746507 Year: Pages: 458 DOI: https://doi.org/10.11647/OBP.0159
Publisher: Open Book Publishers
Subject: Law
Added to DOAB on : 2019-03-12 17:55:05
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Whose Book is it Anyway? is a provocative collection of essays that opens out the copyright debate to questions of open access, ethics, and creativity. It includes views – such as artist’s perspectives, writer’s perspectives, feminist, and international perspectives – that are too often marginalized or elided altogether.

Branching and Rooting Out with a CT Scanner: The Why, the How, and the Outcomes, Present and Possibly Future

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197910 Year: Pages: 91 DOI: 10.3389/978-2-88919-791-0 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2017-02-03 17:04:57
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Until recently, a majority of the applications of X-ray computed tomography (CT) scanning in plant sciences remained descriptive; some included a quantification of the plant materials when the root-soil isolation or branch-leaf separation was satisfactory; and a few involved the modeling of plant biology processes or the assessment of treatment or disease effects on plant biomass and structures during growth. In the last decade, repeated CT scanning of the same plants was reported in an increasing number of studies in which moderate doses of X-rays had been used. Besides the general objectives of Frontiers in Plant Science research topics, “Branching and Rooting Out with a CT Scanner” was proposed to meet specific objectives: (i) providing a non-technical update on knowledge about the application of CT scanning technology to plants, starting with the type of CT scanning data collected (CT images vs. CT numbers) and their processing in the graphical and numerical approaches; (ii) drawing the limits of the CT scanning approach, which because it is based on material density can distinguish materials with contrasting or moderately overlapping densities (e.g., branches vs. leaves, roots vs. non-organic soils) but not the others (e.g., roots vs. organic soils); (iii) explaining with a sufficient level of detail the main procedures used for graphical, quantitative and statistical analyses of plant CT scanning data, including fractal complexity measures and statistics appropriate for repeated plant CT scanning, in experiments where the research hypotheses are about biological processes such as light interception by canopies, root disease development and plant growth under stress conditions; (iv) comparing plant CT scanning with an alternative technology that applies to plants, such as the phenomics platforms which target leaf canopies; and (v) providing current and potential users of plant CT scanning with up-to-date information and exhaustive documentation, including clear perspectives and well-defined goals for the future, for them to be even more efficient or most efficient from start in their research work.

Remote Sensing of Plant Biodiversity

Authors: --- ---
ISBN: 9783030331573 Year: Pages: 581 DOI: 10.1007/978-3-030-33157-3 Language: English
Publisher: Springer Nature
Subject: Environmental Sciences --- Geography --- Botany --- Ecology --- Environmental Technology
Added to DOAB on : 2020-07-15 23:58:39
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This Open Access volume aims to methodologically improve our understanding of biodiversity by linking disciplines that incorporate remote sensing, and uniting data and perspectives in the fields of biology, landscape ecology, and geography. The book provides a framework for how biodiversity can be detected and evaluated—focusing particularly on plants—using proximal and remotely sensed hyperspectral data and other tools such as LiDAR. The volume, whose chapters bring together a large cross-section of the biodiversity community engaged in these methods, attempts to establish a common language across disciplines for understanding and implementing remote sensing of biodiversity across scales. The first part of the book offers a potential basis for remote detection of biodiversity. An overview of the nature of biodiversity is described, along with ways for determining traits of plant biodiversity through spectral analyses across spatial scales and linking spectral data to the tree of life. The second part details what can be detected spectrally and remotely. Specific instrumentation and technologies are described, as well as the technical challenges of detection and data synthesis, collection and processing. The third part discusses spatial resolution and integration across scales and ends with a vision for developing a global biodiversity monitoring system. Topics include spectral and functional variation across habitats and biomes, biodiversity variables for global scale assessment, and the prospects and pitfalls in remote sensing of biodiversity at the global scale.

Data Journeys in the Sciences

Authors: ---
ISBN: 9783030371777 Year: Pages: 412 DOI: 10.1007/978-3-030-37177-7 Language: English
Publisher: Springer Nature
Subject: Science (General)
Added to DOAB on : 2020-07-15 23:58:32
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This groundbreaking, open access volume analyses and compares data practices across several fields through the analysis of specific cases of data journeys. It brings together leading scholars in the philosophy, history and social studies of science to achieve two goals: tracking the travel of data across different spaces, times and domains of research practice; and documenting how such journeys affect the use of data as evidence and the knowledge being produced. The volume captures the opportunities, challenges and concerns involved in making data move from the sites in which they are originally produced to sites where they can be integrated with other data, analysed and re-used for a variety of purposes. The in-depth study of data journeys provides the necessary ground to examine disciplinary, geographical and historical differences and similarities in data management, processing and interpretation, thus identifying the key conditions of possibility for the widespread data sharing associated with Big and Open Data. The chapters are ordered in sections that broadly correspond to different stages of the journeys of data, from their generation to the legitimisation of their use for specific purposes. Additionally, the preface to the volume provides a variety of alternative “roadmaps” aimed to serve the different interests and entry points of readers; and the introduction provides a substantive overview of what data journeys can teach about the methods and epistemology of research.

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