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The Clinical and Ethical Practice of Neuromodulation - Deep Brain Stimulation and Beyond

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453733 Year: Pages: 84 DOI: 10.3389/978-2-88945-373-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2018-11-16 17:17:57
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euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.

Levodopa-induced Dyskinesias in Parkinson's Disease: Current Knowledge and Future Scenarios

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195459 Year: Pages: 99 DOI: 10.3389/978-2-88919-545-9 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
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This topic aims to pool the most recent advances in the phenomenology and pathophysiology of levodopa-induced dyskinesias. The papers in this eBook have strongly contributed to reduce the gaps in our knowledge of LIDs pathogenesis.

Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453177 Year: Pages: 220 DOI: 10.3389/978-2-88945-317-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:45
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The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.

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