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New therapeutic targets for human placental angiogenesis diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194612 Year: Pages: 113 DOI: 10.3389/978-2-88919-461-2 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies.

Solving PDEs in Python: The FEniCS Tutorial I

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Book Series: Simula SpringerBriefs on Computing ISBN: 9783319524610 9783319524627 Year: DOI: 10.1007/978-3-319-52462-7 Language: English
Publisher: Springer Nature
Subject: Computer Science
Added to DOAB on : 2017-04-11 12:12:58
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This book offers a concise and gentle introduction to finite element programming in Python based on the popular FEniCS software library. Using a series of examples, including the Poisson equation, the equations of linear elasticity, the incompressible Navier–Stokes equations, and systems of nonlinear advection–diffusion–reaction equations, it guides readers through the essential steps to quickly solving a PDE in FEniCS, such as how to define a finite variational problem, how to set boundary conditions, how to solve linear and nonlinear systems, and how to visualize solutions and structure finite element Python programs.

Programming Languages and Systems

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Book Series: Lecture Notes in Computer Science ISBN: 9783030171841 Year: Pages: 816 DOI: 10.1007/978-3-030-17184-1 Language: English
Publisher: Springer Nature
Subject: Computer Science
Added to DOAB on : 2020-01-29 11:21:11
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This open access book constitutes the proceedings of the 28th European Symposium on Programming, ESOP 2019, which took place in Prague, Czech Republic, in April 2019, held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2019.

Data Parallel C++

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ISBN: 9781484255742 Year: Pages: 548 DOI: 10.1007/978-1-4842-5574-2 Language: English
Publisher: Springer Nature
Subject: Computer Science
Added to DOAB on : 2020-11-19 00:18:20
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Learn how to accelerate C++ programs using data parallelism. This open access book enables C++ programmers to be at the forefront of this exciting and important new development that is helping to push computing to new levels. It is full of practical advice, detailed explanations, and code examples to illustrate key topics. Data parallelism in C++ enables access to parallel resources in a modern heterogeneous system, freeing you from being locked into any particular computing device. Now a single C++ application can use any combination of devices—including GPUs, CPUs, FPGAs and AI ASICs—that are suitable to the problems at hand. This book begins by introducing data parallelism and foundational topics for effective use of the SYCL standard from the Khronos Group and Data Parallel C++ (DPC++), the open source compiler used in this book. Later chapters cover advanced topics including error handling, hardware-specific programming, communication and synchronization, and memory model considerations. Data Parallel C++ provides you with everything needed to use SYCL for programming heterogeneous systems. What You'll Learn Accelerate C++ programs using data-parallel programming Target multiple device types (e.g. CPU, GPU, FPGA) Use SYCL and SYCL compilers Connect with computing’s heterogeneous future via Intel’s oneAPI initiative Who This Book Is For Those new data-parallel programming and computer programmers interested in data-parallel programming using C++.

Finite Difference Computing with PDEs: A Modern Software Approach

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Book Series: Texts in Computational Science and Engineering ISSN: 1611-0994 / 2197-179X ISBN: 9783319554556 9783319554563 Year: Pages: 507 DOI: https://doi.org/10.1007/978-3-319-55456-3 Language: English
Publisher: Springer Nature
Subject: Computer Science
Added to DOAB on : 2017-11-24 13:03:18
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This easy-to-read book introduces the basics of solving partial differential equations by means of finite difference methods. Unlike many of the traditional academic works on the topic, this book was written for practitioners. Accordingly, it especially addresses: the construction of finite difference schemes, formulation and implementation of algorithms, verification of implementations, analyses of physical behavior as implied by the numerical solutions, and how to apply the methods and software to solve problems in the fields of physics and biology.

Foundations of Software Science and Computation Structures

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Book Series: Lecture Notes in Computer Science ISBN: 9783030171278 Year: Pages: 542 DOI: 10.1007/978-3-030-17127-8 Language: English
Publisher: Springer Nature
Subject: Mathematics --- Computer Science
Added to DOAB on : 2020-01-29 11:21:11
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This open access book constitutes the proceedings of the 22nd International Conference on Foundations of Software Science and Computational Structures, FOSSACS 2019, which took place in Prague, Czech Republic, in April 2019, held as part of the European Joint Conference on Theory and Practice of Software, ETAPS 2019. The 29 papers presented in this volume were carefully reviewed and selected from 85 submissions. They deal with foundational research with a clear significance for software science.

Introduction to Scientific Programming with Python

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Book Series: Simula SpringerBriefs on Computing ISBN: 9783030503567 Year: Pages: 148 DOI: 10.1007/978-3-030-50356-7 Language: English
Publisher: Springer Nature
Subject: Science (General) --- Computer Science
Added to DOAB on : 2020-07-15 23:58:26
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This open access book offers an initial introduction to programming for scientific and computational applications using the Python programming language. The presentation style is compact and example-based, making it suitable for students and researchers with little or no prior experience in programming. The book uses relevant examples from mathematics and the natural sciences to present programming as a practical toolbox that can quickly enable readers to write their own programs for data processing and mathematical modeling. These tools include file reading, plotting, simple text analysis, and using NumPy for numerical computations, which are fundamental building blocks of all programs in data science and computational science. At the same time, readers are introduced to the fundamental concepts of programming, including variables, functions, loops, classes, and object-oriented programming. Accordingly, the book provides a sound basis for further computer science and programming studies.

Evidence-Based Programming for Older Adults

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195855 Year: Pages: 361 DOI: 10.3389/978-2-88919-585-5 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2015-11-02 10:49:06
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There is increased world-wide concern about the impact of multiple chronic conditions, especially among the rapidly aging population. Simultaneously, over the past decade there has been an emergence of state-wide and national initiatives to reduce the burden of chronic conditions that draw upon the translation of evidence-based programs (EPB) into community practice. Yet, little has been written about the national and international implementation, dissemination, and sustainability of such programs. This Research Topic features articles about EBPs for older adults, including a range of articles that focus on the infrastructure needed to widely disseminate EBP as well as individual participant impacts on physical, mental, and social aspects of health and well-being. Using a pragmatic research perspective, this Research Topic will advance knowledge that aims to enhance practice, inform policy and build systems of support and delivery in regard to the reach, effectiveness, adoption, implementation, and maintenance of evidence-based interventions for older adults. The focus is on knowledge transfer rather than knowledge generation but with a dual emphasis on the dissemination and sustainability of EBP that have been tested and shown effective as well as the adaptation of practice-based interventions into evidence-based programs. This Research Topic draws upon grand-scale efforts to deliver these programs, and include both U.S. as well as international examples. Commentaries discuss processes in the development and measurement of EBP and reflect perspectives from program developers and major national and regional funders of EBP as well as professionals and practitioners in the field. The full-length articles focus on four major programmatic areas: (1) chronic disease self-management programs; (2) fall prevention programs; (3) general wellness and physical activity programs; and (4) mental health programs. Additionally, articles are included to discuss cross-cutting issues related to building partnerships and the research infrastructure for the implementation, evaluation, and dissemination of evidence-based programming. The intent of this Research Topic is to enhance practice, inform policy, and build systems of support and delivery for EBP. It is written for a diverse audience and contains practical implications and recommendations for introducing, delivering, and sustaining EBP in a multitude of settings.

Neuroinflammation and Behaviour

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196029 Year: Pages: 181 DOI: 10.3389/978-2-88919-602-9 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
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The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.

Pediatric Hypertension: Update

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456543 Year: Pages: 93 DOI: 10.3389/978-2-88945-654-3 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Pediatrics
Added to DOAB on : 2019-01-23 14:53:43
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Hypertension and its resultant complications do occur in childhood and track into adulthood. It’s estimated that > 3% of all children have hypertension, with an even greater prevalence among obese children (20-47%). The etiology of hypertension is generally described as primary (essential) or secondary with most secondary causes related to cardio-renal disease. While primary hypertension is on the rise, all children should undergo an evaluation to investigate for a secondary cause of their hypertension. Mild to moderate hypertension is most commonly asymptomatic but may be associated with subtle cardiac, renal, neurological and/or psychosocial.

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