Search results: Found 11

Listing 1 - 10 of 11 << page
of 2
>>
Sort by
Suburban Urbanities

Author:
ISBN: 9781910634172 9781910634141 9781910634134 9781910634158 Year: Pages: 374 DOI: 10.14324/111.9781910634134 Language: English
Publisher: UCL Press
Subject: Ethnology
Added to DOAB on : 2015-11-12 11:01:12
License:

Loading...
Export citation

Choose an application

Abstract

Suburban space has traditionally been understood as a formless remnant of physical city expansion, without a dynamic or logic of its own. Suburban Urbanities challenges this view by defining the suburb as a temporally evolving feature of urban growth. Anchored in the architectural research discipline of space syntax, this book offers a comprehensive understanding of urban change, touching on the history of the suburb as well as its current development challenges, with a particular focus on suburban centres. Studies of the high street as a centre for social, economic and cultural exchange provide evidence for its critical role in sustaining local centres over time. Contributors from the architecture, urban design, geography, history and anthropology disciplines examine cases spanning Europe and around the Mediterranean. &#xD;By linking large-scale city mapping, urban design scale expositions of high street activity and local-scale ethnographies, the book underscores the need to consider suburban space on its own terms as a specific and complex field of social practice.

Mother on Mothers

Author:
ISBN: 9783034318266 9783035307917 Year: DOI: 10.3726/978-3-0353-0791-7 Language: English
Publisher: Peter Lang International Academic Publishing Group Grant: Knowledge Unlatched - 103674
Subject: Information theory
Added to DOAB on : 2019-02-15 08:31:14
License:

Loading...
Export citation

Choose an application

Abstract

From Supernanny to Gilmore Girls, from Katie Price to Holly Willoughby, a wide range of examples of mothers and motherhood appear on television today. Drawing on questionnaires completed by mothers across the UK, this book sheds new light on the diverse ways in which mothers make sense of popular representations of motherhood on television.

Basal ganglia: physiological, behavioral, and computational studies

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193882 Year: Pages: 494 DOI: 10.3389/978-2-88919-388-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General)
Added to DOAB on : 2015-12-03 13:02:24
License:

Loading...
Export citation

Choose an application

Abstract

The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research - in both animals and humans - attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.

Chapter 9: 'Crowd Spatial Patterns at Bus Stops: Security Implications and Effects of Warning Messages' from book: Safety and Security in Transit Environments: An Interdisciplinary Approach

Authors: --- ---
ISBN: 9781137556363 Year: Pages: 23 DOI: 10.1057/9781137457653_9 Language: English
Publisher: Palgrave Macmillan
Subject: Social and Public Welfare
Added to DOAB on : 2015-12-18 11:42:04
License:

Loading...
Export citation

Choose an application

Abstract

This is a chapter from Safety and Security in Transit Environments: An Interdisciplinary Approach edited by Vania Ceccato and Andrew Newton. This chapter is available open access under a CC BY license. As other chapters in Safety and Security in Transit Environments assert, crimes such as pickpocketing can concentrate near bus stops, and crowding and congestion is a factor that heightens this risk. But to target interventions effectively, it is useful to determine what local-level interactions characterise this crowding behaviour. This paper aims to provide a first step to using data collected from laboratory experiments to address questions from crime and transport research. The experiment considered differences in interpersonal distances to further analyse crowding behaviour to attain further insight that could narrow the focus of possible interventions. Audio warnings are examined as a possible solution, and findings show that crowding peaks when passengers board the bus, and audio messages may be one approach for addressing this. To conclude, implications of identifying boarding as a problem area, and the effectiveness of warning messages as a situational crime prevention tool are discussed.

Médiations interculturelles entre la France et la Suède: Trajectoires et circulations de 1945 à nos jours

Authors: ---
Book Series: Stockholm Studies in Romance Languages ISBN: 9789176350157 9789176350126 9789176350133 9789176350140 Year: Pages: 314 DOI: 10.16993/bad Language: French|Swedish
Publisher: Stockholm University Press Grant: Åke Wibergs stiftelse, Stockholm, Department of Romance and Classical Studies, Stockholm University
Subject: Social Sciences --- History --- Languages and Literatures
Added to DOAB on : 2016-01-12 11:01:13
License:

Loading...
Export citation

Choose an application

Abstract

Ce livre porte sur les relations culturelles entre la France et la Suède de 1945 à nos jours. Il réunit les articles présentés à l’occasion de la conférence internationale, « Frankrike-Sverige – Tur och retur », qui a eu lieu à Stockholm en janvier 2014, organisée par l’Université Paris-Sorbonne et l’Université de Stockholm. Ces vingt-deux articles tracent ensemble une histoire croisée des médiations matérielles et immatérielles, dynamiques et complexes, ayant permis la construction des identités culturelles dans trois domaines principaux : les représentations et l’imaginaire ; la médiation et les vecteurs de transmission ; la traduction, la réception et la circulation des oeuvres.

Preclinical and clinical issues in Alzheimer's disease drug research and development

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194339 Year: Pages: 100 DOI: 10.3389/978-2-88919-433-9 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend support to the idea that Aß is not causative but can be considered as an “innocent bystander” in AD. Although preclinical research generated impressive lines of evidence about the several intracellular mechanism(s) whose impairment leads to the onset and progression of AD, clinical research aimed at the development of new drugs capable of preventing or delaying the onset of neuronal damage in AD patients has produced limited results. The drugs currently available for the treatment of AD are acetylcholinesterase inhibitors (AChEI) and the NMDA glutamate receptor antagonist memantine. The AChEI increase acetylcholine levels in the synaptic cleft, which are reduced because of the progressive damage of cholinergic neurons in cognitive brain areas (e.g. amygdala, hippocampus, and frontal cortex), whereas memantine is used to prevent/reduce calcium-dependent excitotoxic neuronal cell death. Both classes of drugs have been shown to improve symptoms related to cognitive decline, but their effects are confined largely to patients with mild to moderate AD, in particular during the first year or so of treatment. An alternative to this symptomatic treatments involves the use of drugs that intervene in the pathogenesis of the disease. Recently, monoclonal antibodies against Aß were proposed as novel agents capable to remove Aß from the brain thus preventing neuronal damage. The research topic focuses on the preclinical and clinical evidence about the several factors that contribute to the pathogenesis of AD as well as the potential therapeutic role of new classes of drugs still under preclinical or clinical development.

Making Medicines in Africa: The Political Economy of Industrializing for Local Health

Authors: --- --- ---
ISBN: 9781137571335 9781137546470 Year: Pages: 360 DOI: 10.1057/9781137546470 Language: English
Publisher: Palgrave Macmillan
Subject: Political Science --- Therapeutics
Added to DOAB on : 2015-12-16 18:20:38
License:

Loading...
Export citation

Choose an application

Abstract

This book is open access under a CC-BY license. The importance of the pharmaceutical industry in Sub-Saharan Africa, its claim to policy priority, is rooted in the vast unmet health needs of the sub-continent. Making Medicines in Africa is a collective endeavour, by a group of contributors with a strong African and more broadly Southern presence, to find ways to link technological development, investment and industrial growth in pharmaceuticals to improve access to essential good quality medicines, as part of moving towards universal access to competent health care in Africa. The authors aim to shift the emphasis in international debate and initiatives towards sustained Africa-based and African-led initiatives to tackle this huge challenge. Without the technological, industrial, intellectual, organisational and research-related capabilities associated with competent pharmaceutical production, and without policies that pull the industrial sectors towards serving local health needs, the African sub-continent cannot generate the resources to tackle its populations' needs and demands.

Polemik in den Schriften Melchior Hoffmans: Inszenierungen rhetorischer Streitkultur in der Reformationszeit

Author:
Book Series: Stockholm German and Dutch Studies ISBN: 9789176350195 9789176350164 9789176350171 9789176350188 Year: Pages: 330 DOI: 10.16993/bae Language: German
Publisher: Stockholm University Press Grant: Department of Slavic and Baltic Studies, Finnish, Dutch and German
Subject: Social Sciences --- Religion --- Languages and Literatures --- History of arts
Added to DOAB on : 2016-01-12 11:01:19
License:

Loading...
Export citation

Choose an application

Abstract

Polemik in den Schriften Melchior Hoffmans. Inszenierungen rhetorischer Streitkultur in der Reformationszeit” is a study of pamphlets written as a reaction to, and attempt for, expansion of the Lutheran and Zwinglian Reformation. Melchior Hoffman’s work has, so far, almost solely been investigated by historians of religion and thus focused merely on religious topics and argumentation, and rather seldomly on the literary aspects of his pamphlets – such as rhetorics, argumentation strategies and text compilation. In order to close this gap of research on Melchior Hoffman and – in the sense of a New Historicism approach – give him as a non-canonical author more attention, this book focuses on the literary qualities of the texts. It is thus the first full-length study on Melchior Hoffman by a literary scholar. Not only has little been written on Melchior Hoffman, but also about lay writers in the Reformation at all. Thus, the book delivers new perspectives within the field of Reformation pamphlet writers. Theoretical significance is an integral part of the study, with a focus on developing a new theoretical concept for analyzing polemic texts. The innovative approach combines post-modern theories like (constructivist) Cultural Studies, and Performativity concepts with Communication Analyses and Classical Rhetorics. By doing so, it provides a unique approach to texts from the 16th century, which can easily and reasonably be applied to polemical texts of the 21st century as well as to even older texts than Hoffman’s.&#xD;The book has been written in the research field of German Literature, but will be of great interest for both literary scholars and historians (of religion or culture).

Models and Estimation of Genetic Effects

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194445 Year: Pages: 99 DOI: 10.3389/978-2-88919-444-5 Language: English
Publisher: Frontiers Media SA
Subject: Ecology --- Genetics --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
License:

Loading...
Export citation

Choose an application

Abstract

Ronald Fisher needed to develop elaborate models of genetic effects in order to set the foundations of Quantitative Genetics in his 1918 paper “The correlation between relatives on the supposition of Mendelian inheritance”. Since then, many significant implementations have been made to model genetic effects. However, at the verge of one century after Fisher’s kick-off, models of genetic effects keep on being discussed and implemented. Indeed, the relatively recent advent of QTL analyses challenged the state of the art of this field by providing researchers the opportunity to obtain and analyze estimates of genetic effects from real data. In this context, the development of this field was not exempt of some polemics, like the debate about the convenience of the functional and the statistical epistasis approaches. This research topic is meant to provide recent developments in models and estimation of genetic effects and to enrich the discussion about how and why models of genetic effects must be further developed and applied.The articles in this Research Topic shall thus extend, refine and/or provide a refresh look at Fisher’s original models of genetic effects and their application to genetic effects estimation and to improve our understanding of evolutionary processes and breeding programs.

Phytoalexins: Current Progress and Future Prospects

ISBN: 9783038420583 9783038420590 Year: Pages: 516 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 11:33:35
License:

Loading...
Export citation

Choose an application

Abstract

Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. It is now clear that phytoalexins exhibit toxicity across much of the biological spectrum, prokaryotic and eukaryotic. Starting in the 1950s, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their structure, their biological activity as well as mechanisms of their synthesis and their catabolism by microorganisms. Elucidation of the biosynthesis of numerous phytoalexins has also permitted the use of molecular biology tools for the exploration of the genes encoding enzymes of their synthesis pathways and their regulators. This has led to potential applications for increasing plant resistance to diseases. Phytoalexins display an enormous diversity belonging to various chemical families such as isoflavones, isoflavanones, pterocarpans, isoflavans, flavanones, coumestans, furanoacetylenes, phenylpropanoids, steroid glycoalkaloids, norsesquiterpenoids/sesquiterpenoids, coumarins, diterpenes, ent-kaurane-related diterpenoids, acidic sesquiterpenoids, 3-deoxyanthocyanidins, naphthaldehydes, indoles and stilbenes.Research papers dealing with all aspects of phytoalexins, including structure elucidation; chemical synthesis; methods for phytoalexin analysis in plant extracts or biological fluids; biosynthesis studies including modulation of phytoalexin synthesis; engineering of phytoalexin biochemical pathways in plants and microbes; biological activities; structure/activity relationships; phytoalexin metabolism in planta and by micro-organisms; roles and ATP Binding Cassette (ABC) transporters or Multi-Drugs Efflux (MDE) transporters are welcome for inclusion in this Special Issue of Molecules. Review articles, particularly those dealing with the themes mentioned above are also particularly welcome for inclusion.

Listing 1 - 10 of 11 << page
of 2
>>
Sort by