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Bioinspired Catechol- Based Systems: Chemistry and Applications

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ISBN: 9783038428138 9783038428145 Year: Pages: 204 DOI: 10.3390/books978-3-03842-814-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-03-16 13:15:34
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Catechols are widely found in nature taking part in a variety of biological functions, ranging from the aqueous adhesion of marine organisms to the storage of transition metal ions. Catechol-based natural and biomimetic molecules have thus been the focus of intense research aimed at mimicking and translating this nature-inspired chemistry into new functional materials and systems with tailored properties. The aim of this book is to present a concise survey of the state-of-the-art of basic and applied research on bioinspired catechol systems. It collects several cutting-edge contributions from leading laboratories with a unifying theme of biomimetic principles and approaches. It is hoped that both practitioners and newcomers to the field will by fascinated by the unique potential of biomimetics to pursue new research and innovative solutions in biomedicine and technology.

Antioxidants in Health and Disease Volume 1

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ISBN: 9783038428855 9783038428862 Year: Volume: 1 Pages: X, 436 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-05-18 14:34:25
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Several epidemiological studies have demonstrated that oxidative stress is associated with a number of health disorders, including cardiovascular malfunction, certain types of cancer, diabetes mellitus, many other auto-immune diseases, and even ageing. The body possesses multiple mechanisms to counteract oxidative stress, which employ antioxidant compounds that are either naturally generated in situ (endogenous antioxidants) or externally supplied through food (exogenous antioxidants). These antioxidants are able to counteract oxidative stress, thanks to their ability to neutralize excess free radicals and protect the cellular lipids, proteins, and DNA from molecular damage. Exogenous antioxidants from the diet are of increasing interest because of their beneficial role in maintaining good health and in preventing chronic diseases. Indeed, a diet rich in dietary antioxidants, especially from fruits and vegetables, has been correlated with a successful prevention and lower incidence of several degenerative pathologies, including obesity, diabetes, cardiovascular diseases, and cancer.This Special Issue of Nutrients welcomes the submission of manuscripts, either describing original research or reviewing scientific literature, examining the role of diets rich in antioxidant compounds in the prevention of chronic diseases and the characteristics of the antioxidants included in such diets.

Antioxidants in Health and Disease Volume 2

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ISBN: 9783038429395 9783038429401 Year: Volume: 2 Pages: VIII, 264 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-05-18 15:15:28
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Several epidemiological studies have demonstrated that oxidative stress is associated with a number of health disorders, including cardiovascular malfunction, certain types of cancer, diabetes mellitus, many other auto-immune diseases, and even ageing. The body possesses multiple mechanisms to counteract oxidative stress, which employ antioxidant compounds that are either naturally generated in situ (endogenous antioxidants) or externally supplied through food (exogenous antioxidants). These antioxidants are able to counteract oxidative stress, thanks to their ability to neutralize excess free radicals and protect the cellular lipids, proteins, and DNA from molecular damage. Exogenous antioxidants from the diet are of increasing interest because of their beneficial role in maintaining good health and in preventing chronic diseases. Indeed, a diet rich in dietary antioxidants, especially from fruits and vegetables, has been correlated with a successful prevention and lower incidence of several degenerative pathologies, including obesity, diabetes, cardiovascular diseases, and cancer.This Special Issue of Nutrients welcomes the submission of manuscripts, either describing original research or reviewing scientific literature, examining the role of diets rich in antioxidant compounds in the prevention of chronic diseases and the characteristics of the antioxidants included in such diets.

Effects of Polyphenol-Rich Foods on Human Health

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ISBN: 9783038971351 9783038971368 Year: Volume: 1 Pages: XII, 430 Language: Englisch
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-08-27 16:11:04
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Over the last few years, polyphenol has received a great deal of attention due to their potential beneficial effects on human health. Widely contained in foods commonly consumed in all populations worldwide, polyphenols represent an attractive explanation of the beneficial effects, not only of fruits and vegetables, characteristic components of healthy dietary patterns, but also of other plant-derived foods, such as tea, coffee, and cocoa, which only recently have been exploited as being beneficial for humans. In addition to the numerous biological properties, polyphenols have been indicated as being responsible for a decreased risk of metabolic disorders, cardiovascular disease, and certain cancers. The book addresses original research and reviews of literature concerning polyphenol-rich foods and human health.

Effects of Polyphenol-Rich Foods on Human Health

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ISBN: 9783038971412 9783038971429 Year: Volume: 2 Pages: XII, 350 Language: Englisch
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-08-27 16:35:29
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Over the last few years, polyphenol has received a great deal of attention due to their potential beneficial effects on human health. Widely contained in foods commonly consumed in all populations worldwide, polyphenols represent an attractive explanation of the beneficial effects, not only of fruits and vegetables, characteristic components of healthy dietary patterns, but also of other plant-derived foods, such as tea, coffee, and cocoa, which only recently have been exploited as being beneficial for humans. In addition to the numerous biological properties, polyphenols have been indicated as being responsible for a decreased risk of metabolic disorders, cardiovascular disease, and certain cancers. The book addresses original research and reviews of literature concerning polyphenol-rich foods and human health.

Effects of Polyphenol-Rich Foods on Human Health

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ISBN: 9783038971436 9783038971443 Year: Volume: 3 Pages: XII, 344 Language: Englisch
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-08-27 16:54:12
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Over the last few years, polyphenol has received a great deal of attention due to their potential beneficial effects on human health. Widely contained in foods commonly consumed in all populations worldwide, polyphenols represent an attractive explanation of the beneficial effects, not only of fruits and vegetables, characteristic components of healthy dietary patterns, but also of other plant-derived foods, such as tea, coffee, and cocoa, which only recently have been exploited as being beneficial for humans. In addition to the numerous biological properties, polyphenols have been indicated as being responsible for a decreased risk of metabolic disorders, cardiovascular disease, and certain cancers. The book addresses original research and reviews of literature concerning polyphenol-rich foods and human health.

Dietary Antioxidants and Prevention of Non-Communicable Diseases

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ISBN: 9783038972266 9783038972273 Year: Pages: 216 DOI: 10.3390/books978-3-03897-227-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-10-11 09:46:24
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Numerous epidemiological studies have demonstrated the association between oxidative stress and non-communicable disease, including cardiovascular disorders, mental disease, and several types of cancer. Oxidative stress is commonly known as an imbalance in the production of reactive oxygen species (ROS) and the biological antioxidant defense system. Exogenous antioxidants have gained great attention because of their beneficial role in preventing chronic disease. A balanced diet contains hundreds of naturally occurring antioxidant compounds, including polyphenols and vitamins. Antioxidants are commonly found in vegetables, fruits, cocoa, grain cereals, olive oil, nuts and beverages, such as coffee and tea.This book presents original research and reviews of literature concerning dietary antioxidants and human health.

Antioxidants and Second Messengers of Free Radicals

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ISBN: 9783038975335 / 9783038975342 Year: Pages: 194 DOI: 10.3390/books978-3-03897-534-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Medicine (General) --- Chemistry (General)
Added to DOAB on : 2019-01-17 09:35:49
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The history of science can teach modern men that our understanding of life is to a great extent based on the accuracy of the analytical methods that we use and, on our readiness to oppose dogmatic opinions, which are based on outdated methods and black/white approaches to the major questions raised by mankind in the past. The recent decades have brought a lot of new insights into the fundamentals of the active principles of reactive oxygen species that are necessary for living cells, but which also cause dangerous pathophysiological processes. Accordingly, although they were previously considered to be the most undesired toxic compounds generated as the final products of the oxidative degradation of lipids, reactive aldehydes are now considered to play important roles both in health and in major diseases. Represented mostly by 4-hydroxynonenal (HNE), a substance discovered only fifty years ago, reactive aldehydes are the focus of research not only because of their toxicity but also because of their positive effects regulating the most important metabolic processes such as growth of living cells or the death of cells. Better understanding the interactions between reactive aldehydes and natural or synthetic antioxidant substances might eventually help us to better monitor, prevent and control modern diseases, thus building pillars for the development of the modern, multidisciplinary life sciences and integrative medicine of the 21st century.

Thioredoxin and Glutaredoxin Systems

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ISBN: 9783038978367 / 9783038978374 Year: Pages: 280 DOI: 10.3390/books978-3-03897-837-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-06-26 08:44:06
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This Special Issue features recent data concerning thioredoxins and glutaredoxins from various biological systems, including bacteria, mammals, and plants. Four of the sixteen articles are review papers that deal with the regulation of development of the effect of hydrogen peroxide and the interactions between oxidants and reductants, the description of methionine sulfoxide reductases, detoxification enzymes that require thioredoxin or glutaredoxin, and the response of plants to cold stress, respectively. This is followed by eleven research articles that focus on a reductant of thioredoxin in bacteria, a thioredoxin reductase, and a variety of plant and bacterial thioredoxins, including the m, f, o, and h isoforms and their targets. Various parameters are studied, including genetic, structural, and physiological properties of these systems. The redox regulation of monodehydroascorbate reductase, aminolevulinic acid dehydratase, and cytosolic isocitrate dehydrogenase could have very important consequences in plant metabolism. Also, the properties of the mitochondrial o-type thioredoxins and their unexpected capacity to bind iron–sulfur center (ISC) structures open new developments concerning the redox mitochondrial function and possibly ISC assembly in mitochondria. The final paper discusses interesting biotechnological applications of thioredoxin for breadmaking.

Keywords

methionine --- methionine sulfoxide --- methionine sulfoxide reductase --- physiological function --- protein --- plant --- repair --- redox homeostasis --- signaling --- stress --- mitochondria --- thioredoxin --- iron–sulfur cluster --- redox regulation --- ALAD --- tetrapyrrole biosynthesis --- redox control --- thioredoxins --- posttranslational modification --- chlorophyll --- redox regulation --- thioredoxin --- ferredoxin-thioredoxin reductase --- chloroplast --- H2O2 --- redox signalling --- development --- regeneration --- adult stem cells --- metazoan --- cyanobacteria --- thioredoxin --- photosynthesis --- redox active site --- thioredoxin --- disulfide --- flavin --- NADPH --- X-ray crystallography --- SAXS --- methanoarchaea --- chilling stress --- cold temperature --- posttranslational modification --- regulation --- ROS --- thiol redox network --- thioredoxin --- thioredoxin --- Calvin-Benson cycle --- photosynthesis --- carbon fixation --- chloroplast --- macromolecular crystallography --- protein-protein recognition --- electrostatic surface --- Chlamydomonas reinhardtii --- thioredoxin --- glutaredoxin --- legume plant --- symbiosis --- redox homeostasis --- stress --- thioredoxin --- monodehydroascorbate reductase --- water stress --- protein oxidation --- antioxidants --- ascorbate --- glutathione --- wheat --- thioredoxin --- thioredoxin reductase --- baking --- redox --- dough rheology --- protein oxidation --- methionine oxidation --- methionine sulfoxide reductases --- oxidized protein repair --- ageing --- Chlamydomonas reinhardtii --- cysteine alkylation --- cysteine reactivity --- MALDI-TOF mass spectrometry --- thioredoxin --- X-ray crystallography --- Isocitrate dehydrogenase --- glutathionylation --- nitrosylation --- glutaredoxin --- Arabidopsis thaliana --- thioredoxins --- plastidial --- specificity --- function --- proteomic --- photosynthesis --- Calvin cycle --- n/a

Biological Potential and Medical Use of Secondary Metabolites

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ISBN: 9783039211876 / 9783039211883 Year: Pages: 284 DOI: 10.3390/books978-3-03921-188-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Keywords

Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds

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CC by-nc-nd (12)


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english (5)

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2019 (5)

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