Search results: Found 39

Listing 1 - 10 of 39 << page
of 4
>>
Sort by
Dual sourcing : with arbitrary stochastic demand and stochastic lead times

Author:
ISBN: 9783866445284 Year: Pages: XVIII, 337 p. DOI: 10.5445/KSP/1000018435 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Business and Management
Added to DOAB on : 2019-07-30 20:01:58
License:

Loading...
Export citation

Choose an application

Abstract

Companies with high-performing supply chains enjoy essential competitive ad- vantages. However, supply chain management faces an environment of rising risk that endangers these competitive advantages. One of the reasons is to outsource parts of their business. This bears the risk of significantly increased lead times and lead time variability. It is the impact of lead time variability on inventory management that is the central aspect of this book. It describes a mathematical model for dual sourcing with two reorder points, shows the deviation between stochastic and deterministic calculations in a sensitivity analysis, and investigates different relaxations of a traditional dual-sourcing policy.

Vitamin E

Author:
ISBN: 9783038429050 9783038429067 Year: Pages: VIII, 150 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2018-05-22 09:52:09
License:

Loading...
Export citation

Choose an application

Abstract

Vitamin E is the major lipid-soluble antioxidant in the cell antioxidant system and is exclusively obtained from the diet. In 1922, vitamin E was discovered as a dietary factor essential for reproduction in rats. Meanwhile, vitamin E has revealed many more important molecular properties, such as the scavenging of reactive oxygen and nitrogen species with consequent prevention of the oxidative damage associated with many diseases. In addition, the modulation of signal transduction and gene expression in antioxidant and non-antioxidant manners was shown for vitamin E.This Special Issue highlights some of the recent advances in vitamin E research, showing on the one hand the status quo and providing, on the other hand, new insights into functions and physiological relevance. Thus, the current knowledge of tocochromanol biosynthesis in plants and future challenges regarding the understanding of its regulation are presented. Another paper describes the fate of vitamin E in the human gastrointestinal lumen during digestion. During the metabolism of vitamin E, the long-chain metabolites 13’-hydroxychromanol and 13’-carboxychromanol are formed by oxidative modification of the side-chain. Their occurrence in human serum indicates a physiological relevance. Another paper describes the membrane distribution of α-tocopherol in brain regions of adult rhesus monkeys, also looking for associations between membrane α-tocopherol and the content of polyunsaturated fatty acids.

Heterogeneity, High Performance Computing, Self-Organization and the Cloud

Authors: --- ---
Book Series: Palgrave Studies in Digital Business & Enabling Technologies ISBN: 9783319760377 9783319760384 Year: Pages: 165 DOI: https://doi.org/10.1007/978-3-319-76038-4 Language: English
Publisher: Palgrave Macmillan Grant: European Commission; Irish Centre for Cloud Computing and Commerce
Subject: Business and Management --- Computer Science
Added to DOAB on : 2018-07-20 18:56:40
License:

Loading...
Export citation

Choose an application

Abstract

This open access book addresses the most recent developments in cloud computing such as HPC in the Cloud, heterogeneous cloud, self-organising and self-management, and discusses the business implications of cloud computing adoption. Establishing the need for a new architecture for cloud computing, it discusses a novel cloud management and delivery architecture based on the principles of self-organisation and self-management. This focus shifts the deployment and optimisation effort from the consumer to the software stack running on the cloud infrastructure. It also outlines validation challenges and introduces a novel generalised extensible simulation framework to illustrate the effectiveness, performance and scalability of self-organising and self-managing delivery models on hyperscale cloud infrastructures. It concludes with a number of potential use cases for self-organising, self-managing clouds and the impact on those businesses.

Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease

Author:
ISBN: 9783038972402 9783038972419 Year: Pages: 238 DOI: 10.3390/books978-3-03897-241-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health --- Therapeutics
Added to DOAB on : 2018-10-16 10:00:26
License:

Loading...
Export citation

Choose an application

Abstract

Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features. The diagnosis of MRC disorders can be complex, and requires a coordinated interplay of a number of disciplines. However, biochemical determination of metabolites in blood, cerebral spinal fluid (CSF) and/or urine are generally considered to be first-line investigations for the diagnosis of these disorders, although they lack sensitivity and specificity. Furthermore, there is a lack of consensus on the overall utility of monitoring other biochemical parameters, which may be of diagnostic value. For example, although oxidative stress may contribute to the pathogenesis of mitochondrial disorders, few centers monitor this as part of their diagnostic repertoire. Therefore, the purpose of this Special Issue was to highlight potential biomarkers of mitochondrial disease and to discuss the appropriateness of biochemical markers to monitor disease progression and therapeutic intervention.

Plant Mitochondria

Author:
ISBN: 9783038975502 / 9783038975519 Year: Pages: 400 DOI: 10.3390/books978-3-03897-551-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Plant Sciences
Added to DOAB on : 2019-02-19 09:53:15
License:

Loading...
Export citation

Choose an application

Abstract

The primary function of mitochondria is respiration, where the catabolism of substrates is coupled to ATP synthesis via oxidative phosphorylation. In plants, mitochondrial composition is relatively complex and flexible and has specific pathways to support photosynthetic processes in illuminated leaves. Plant mitochondria also play important roles in a variety of cellular processes associated with carbon, nitrogen, phosphorus, and sulfur metabolism. Research on plant mitochondria has rapidly developed in the last few decades with the availability of the genome sequences for a wide range of model and crop plants. Recent prominent themes in plant mitochondrial research include linking mitochondrial composition to environmental stress responses, and how this oxidative stress impacts on the plant mitochondrial function. Similarly, interest in the signaling capacity of mitochondria, the role of reactive oxygen species, and retrograde and anterograde signaling has revealed the transcriptional changes of stress responsive genes as a framework to define specific signals emanating to and from the mitochondrion. There has also been considerable interest in the unique RNA metabolic processes in plant mitochondria, including RNA transcription, RNA editing, the splicing of group I and group II introns, and RNA degradation and translation. Despite their identification more than 100 years ago, plant mitochondria remain a significant area of research in the plant sciences. This Special Issue, “Plant Mitochondria”, will cover a selection of recent research topics and timely review articles in the field of plant mitochondrial research.

Functional elements and engineering template-based product development process. Application for the support of stamping tool design

Author:
Book Series: Reihe Informationsmanagement im Engineering Karlsruhe / Hrsg.: Universität Karlsruhe (TH), Institut für Informationsmanagement im Ingenieurwesen (IMI) ISSN: 18605990 ISBN: 3866440332 Year: Volume: 2006,1 Pages: XV, 201 p. DOI: 10.5445/KSP/1000004821 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
License:

Loading...
Export citation

Choose an application

Abstract

This thesis proposes a product design solution based on functional elements and particularly on one of its sub-categories called engineering templates. The approach supports the development process to reach the common goals of time reduction and quality enhancement by shortening the product development times, enabling continuous information flows and capitalizing on engineering knowledge. An example based on the template of a stamping tool illustrates the influence of templates on process chain shaping and evidences their utility for the concurrent engineering concept.

Nutrition and Liver Disease

Authors: ---
ISBN: 9783038429234 9783038429241 Year: Pages: X, 148 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Medicine (General)
Added to DOAB on : 2018-06-22 11:47:05
License:

Loading...
Export citation

Choose an application

Abstract

Malnutrition in people with liver disease is a challenging issue due to its multifactorial nature, which includes hypermetabolism, increased energy needs, malabsorption, and anorexia. Despite advances in both assessment and management, correct nutritional support is still an often-unanswered need in the care of these patients to avoid poor outcomes. One of the central issues remains how to improve muscolar mass of sarcopenic chronically malnourished individuals with end stage liver diseases and cirrhosis, as only a correct nutritional assessment and subsequent nutritional handling may enhance quality of life and disease outcome. Nutritional management is mandatory in certain inherited metabolic/genetic defects: in these patients specific dietary restrictions/supplementations represent a challenge to guarantee optimal growth and liver health.A nutraceutical approach dealing with hepatoprotective effects of specific nutrients, has been proposed for several chronic liver disease, mainly in obesity related liver disease and alcoholic liver disease. Finally, other challenges are represented by tailored nutritional intervention in improving gut–liver axis dysfunction also in parenteral nutrition/intestinal failure associated liver disease, inflammatory bowel disease, and celiac disease.The purpose of this Special Issue, “Nutrition and Liver Disease”, is to provide novel information and perspectives in the field of nutrition in liver disease and its management.

Brewing and Craft Beer

Author:
ISBN: 9783039214891 / 9783039214907 Year: Pages: 140 DOI: 10.3390/books978-3-03921-490-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 16:10:12
License:

Loading...
Export citation

Choose an application

Abstract

Beer is a beverage with more than 8000 years of history, and the process of brewing has not changed much over the centuries. However, important technical advances have allowed us to produce beer in a more sophisticated and efficient way. The proliferation of specialty hop varieties has been behind the popularity of craft beers seen in the past few years around the world. Craft brewers interpret historic beer with unique styles. Craft beers are undergoing an unprecedented period of growth, and more than 150 beer styles are currently recognized. This Special Issue, Brewing and Craft Beer, comprises nine different works by researchers from five continents (North America, South America, Europe, Africa, and Oceania). This Special Issue reflects thus a broad perspective on the most important questions that concern the researchers in different parts of the world.

Algorithms for Scheduling Problems

Authors: --- ---
ISBN: 9783038971191 9783038971207 Year: Pages: XIV, 194 Language: Englisch
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Computer Science --- Mathematics
Added to DOAB on : 2018-08-24 16:46:30
License:

Loading...
Export citation

Choose an application

Abstract

This edited book presents new results in the area of algorithm development for different types of scheduling problems. In eleven chapters, algorithms for single machine problems, flow-shop and job-shop scheduling problems (including their hybrid (flexible) variants), the resource-constrained project scheduling problem, scheduling problems in complex manufacturing systems and supply chains, and workflow scheduling problems are given. The chapters address such subjects as insertion heuristics for energy-efficient scheduling, the re-scheduling of train traffic in real time, control algorithms for short-term scheduling in manufacturing systems, bi-objective optimization of tortilla production, scheduling problems with uncertain (interval) processing times, workflow scheduling for digital signal processor (DSP) clusters, and many more.

Towards Sustainable Global Food Systems. Conceptual and Policy Analysis of Agriculture, Food and Environment Linkages

Authors: ---
ISBN: 9783038978145 9783038978152 Year: Pages: 356 DOI: 10.3390/books978-3-03897-815-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Environmental Technology
Added to DOAB on : 2019-05-09 17:16:14
License:

Loading...
Export citation

Choose an application

Abstract

One of the major knowledge challenges in the domain of Resilient and Sustainable Food Systems refers to the integration of perspectives on consumption, patterns that support public health, inclusive value chains, and environmentally sustainable food production. While there is a long record of the analysis of separate interventions, this special issue generates integrated insights, provides cross-cutting perspectives, and outlines practical and policy solutions that address these global challenges.The collection of papers promotes the view that sustainable food systems require thorough insights into the structure and dynamics of agri-food production systems, the drivers for integrating food value chains and markets, and key incentives for supporting healthier consumer choices. On the production side, potential linkages between agricultural commercialization and intensification and their effects for food security and nutritional outcomes are analyzed. Value Chains are assessed for their contribution to improving exchange networks and markets for food products that simultaneously support efficiency, circularity, and responsiveness. Individual motives and market structures for food consumption need to be understood in order to be able to outline suitable incentives to enhance healthy dietary choice.The contributed papers focus on interfaces between food system activities and processes of adaptive change that are critical for overcoming key constraints and trade-offs between sustainable food and healthy diets.

Keywords

agricultural impacts --- climate change impacts --- integrated assessment model --- CGE model --- Ostrea edulis --- native oyster restoration --- North Sea --- site selection --- pilot study --- offshore wind farms --- sustainability --- food systems --- nutrition --- public-private cooperation --- corporate values --- sanitary control --- food safety --- prosperity --- sustainable development --- alternative agri-food networks --- transition theories --- grassroots innovations --- socio-technical systems --- agroecology --- ecovillages --- social movements --- certification --- organic agriculture --- Participatory Guarantee Systems --- Spain --- alternative certification systems --- food systems --- metrics --- interdisciplinarity --- sustainable food and nutrition security --- food system assessment --- participatory approach --- SUSFANS --- agribusiness cluster --- commercialization --- sustainable intensification --- dairy value chain --- farming system --- service arrangements --- Ethiopia --- Kenya --- sustainable diets --- diet adoption --- sustainable food system --- intention-behavior gap --- citizen participation --- innovation workshop --- Agricultural commercialization --- food and nutrition security --- salutogenesis --- life course perspective --- food systems --- multi-level --- positive deviance --- Myanmar --- social innovation --- agricultural commercialization --- nutrition sensitive transformation --- Myanmar --- vegetable consumption --- food choice motives --- knowledge --- self-efficacy --- socio-economic classes --- food environment --- Nigeria --- sustainable development goals --- sustainability assessment --- agricultural sustainability --- food security --- LCA broadening --- LCA deepening --- food systems --- interdisciplinary research --- feedbacks &amp --- interlinkages --- food policy --- 3I Approach --- value chain development --- participatory approach --- context-specific interventions --- behavioural change --- postharvest losses --- tomato --- Nigeria --- supply chain --- raffia basket --- plastic crate --- systems approach --- conceptual framework --- food loss practices --- food loss causes --- food loss solutions --- supply-chain stages --- literature --- socio-economic indicators --- tomato --- Nigeria --- adoption --- conservation agriculture --- social capital --- count outcome models --- pca --- marginal treatment effects --- Nigeria --- food security --- CGE model --- nutrition --- diet diversity --- land substitution --- agricultural intensification --- baseline projections --- commercialization --- Vietnam --- food system --- fertilizer use --- caloric intake --- dietary diversity Vietnam Living Standards Survey (VLSS)

Listing 1 - 10 of 39 << page
of 4
>>
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (36)

KIT Scientific Publishing (2)

Palgrave Macmillan (1)


License

CC by-nc-nd (39)


Language

eng (31)

english (7)

englisch (1)


Year
From To Submit

2019 (32)

2018 (5)

2010 (1)

2006 (1)