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Advances in Neuroimmunology

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ISBN: 9783038425700 9783038425717 Year: Pages: X, 150 DOI: 10.3390/books978-3-03842-571-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-12-06 12:41:40
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Neuroimmunity is a relative new and rapidly expanding area of interest that critically impacts normal brain function and a wide range of neurological disorders. Neuroimmune mechanisms operate within the nervous system and between the nervous system and periphery. Glial cells of the nervous system play a primary role in neuroimmunity, through their ability to produce and respond to neuroimmune signaling factors, which serve a number of functions, such as homeostatic regulation of nervous system function and defense against insult and infection. Dysfunction of the neuroimmune system is now thought to be an important contributing factor to many disease and injury states.The purpose of this Special Issue is to provide a representative view of current research in this growing field, with an emphasis on the central nervous system.

The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development

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ISBN: 9783039217021 9783039217038 Year: Pages: 188 DOI: 10.3390/books978-3-03921-703-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:16
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The prefrontal cortex (PFC) plays a pivotal role in regulating our emotions. The importance of ventromedial regions in emotion regulation, including the ventral sector of the medial PFC, the medial sector of the orbital cortex and subgenual cingulate cortex, have been recognized for a long time. However, it is increasingly apparent that lateral and dorsal regions of the PFC, as well as neighbouring dorsal anterior cingulate cortex, also play a role. Defining the underlying psychological mechanisms by which these functionally distinct regions modulate emotions and the nature and extent of their interactions is a critical step towards better stratification of the symptoms of mood and anxiety disorders. It is also important to extend our understanding of these prefrontal circuits in development. Specifically, it is important to determine whether they exhibit differential sensitivity to perturbations by known risk factors such as stress and inflammation at distinct developmental epochs. This Special Issue brings together the most recent research in humans and other animals that addresses these important issues, and in doing so, highlights the value of the translational approach.

Dynamics Days Latin America and the Caribbean 2018

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ISBN: 9783039215034 9783039215041 Year: Pages: 142 DOI: 10.3390/books978-3-03921-504-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-12-09 16:10:12
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This book contains various works presented at the Dynamics Days Latin America and the Caribbean (DDays LAC) 2018. Since its beginnings, a key goal of the DDays LAC has been to promote cross-fertilization of ideas from different areas within nonlinear dynamics. On this occasion, the contributions range from experimental to theoretical research, including (but not limited to) chaos, control theory, synchronization, statistical physics, stochastic processes, complex systems and networks, nonlinear time-series analysis, computational methods, fluid dynamics, nonlinear waves, pattern formation, population dynamics, ecological modeling, neural dynamics, and systems biology. The interested reader will find this book to be a useful reference in identifying ground-breaking problems in Physics, Mathematics, Engineering, and Interdisciplinary Sciences, with innovative models and methods that provide insightful solutions. This book is a must-read for anyone looking for new developments of Applied Mathematics and Physics in connection with complex systems, synchronization, neural dynamics, fluid dynamics, ecological networks, and epidemics.

The Molecular and Cellular Basis for Parkinson's Disease

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ISBN: 9783039215485 9783039215492 Year: Pages: 230 DOI: 10.3390/books978-3-03921-549-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:15
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The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Keywords

epigenetics --- Parkinson’s disease --- brain --- DNA methylation --- Parkinson’s disease --- fatty acid ?-oxidation --- long-chain acylcarnitine --- Parkinson’s disease --- fatty acyls --- glycerolipids --- glycerophospholipids --- sphingolipids --- sterol lipids --- lipoproteins --- ?-synuclein-mediated pathology --- disease-modifying effects --- neuroprotection --- autophagy --- cysteinyl-dopamine --- hypochlorite --- oxidative stress --- Parkinson’s disease --- redox cycling --- Parkinson’s disease --- brain iron --- motor dysfunction --- neurometabolites --- magnetic resonance imaging --- magnetic resonance spectroscopy --- GABA --- spectroscopy --- Parkinson’s disease --- neuroinflammation --- alpha-Synuclein --- immunotherapy --- mesenchymal stem cells --- secretome --- exosomes --- Parkinson’s disease --- microRNAs --- Parkinson disease --- multiprofessional therapy --- inpatient treatment --- multimodal complex treatment --- caffeic acid --- chlorogenic acid --- rotenone --- Parkinson’s disease --- neuroprotection --- dopaminergic neuron --- myenteric plexus --- enteric glial cell --- metallothionein --- Parkinson’s disease --- microbiota --- molecular mimicry --- microbiome --- alpha-synuclein --- curli --- gut-brain axis --- neurodegeneration --- glucocerebrosidase --- Parkinson’s disease --- Gaucher’s disease --- Lewy Body Dementia --- REM sleep behavior disorders --- [123I]FP-CIT-SPECT --- DAT --- nigral cells --- Parkinson’s disease --- parkinsonisms --- cell line --- differentiation --- HOG --- immature oligodendrocyte --- Krabbe’s disease --- oligodendrocyte --- mature oligodendrocyte --- MO3.13 --- myelin --- multiple sclerosis --- schizophrenia --- SH-SY5Y

Symmetry in Classical and Fuzzy Algebraic Hypercompositional Structures

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ISBN: 9783039287086 / 9783039287093 Year: Pages: 208 DOI: 10.3390/books978-3-03928-709-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2020-06-09 16:38:57
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This book is a collection of 12 innovative research papers in the field of hypercompositional algebra, 7 of them being more theoretically oriented, with the other 5 presenting strong applicative aspects in engineering, control theory, artificial intelligence, and graph theory. Hypercompositional algebra is now a well-established branch of abstract algebra dealing with structures endowed with multi-valued operations, also called hyperoperations, having a set as the result of the interrelation between two elements of the support set. The theoretical papers in this book are principally related to three main topics: (semi)hypergroups, hyperfields, and BCK-algebra. Heidari and Cristea present a natural generalization of breakable semigroups, defining the breakable semihypergroups where every non-empty subset is a subsemihypergroup. Using the fundamental relation ? on a hypergroup, some new properties of the

Control and Nonlinear Dynamics on Energy Conversion Systems

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ISBN: 9783039211104 9783039211111 Year: Pages: 438 DOI: 10.3390/books978-3-03921-111-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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The ever-increasing need for higher efficiency, smaller size, and lower cost make the analysis, understanding, and design of energy conversion systems extremely important, interesting, and even imperative. One of the most neglected features in the study of such systems is the effect of the inherent nonlinearities on the stability of the system. Due to these nonlinearities, these devices may exhibit undesirable and complex dynamics, which are the focus of many researchers. Even though a lot of research has taken place in this area during the last 20 years, it is still an active research topic for mainstream power engineers. This research has demonstrated that these systems can become unstable with a direct result in increased losses, extra subharmonics, and even uncontrollability/unobservability. The detailed study of these systems can help in the design of smaller, lighter, and less expensive converters that are particularly important in emerging areas of research like electric vehicles, smart grids, renewable energy sources, and others. The aim of this Special Issue is to cover control and nonlinear aspects of instabilities in different energy conversion systems: theoretical, analysis modelling, and practical solutions for such emerging applications. In this Special Issue, we present novel research works in different areas of the control and nonlinear dynamics of energy conversion systems.

Keywords

data-driven --- prediction --- neural network --- air-handling unit (AHU) --- supply air temperature --- pulverizing system --- soft sensor --- inferential control --- moving horizon estimation --- multi-model predictive control --- micro-grid --- droop control --- virtual impedance --- harmonic suppression --- power quality --- combined heat and power unit --- two-stage bypass --- dynamic model --- coordinated control system --- predictive control --- decoupling control --- power conversion --- model–plant mismatches --- disturbance observer --- performance recovery --- offset-free --- electrical machine --- electromagnetic vibration --- multiphysics --- rotor dynamics --- air gap eccentricity --- calculation method --- magnetic saturation --- corrugated pipe --- whistling noise --- Helmholtz number --- excited modes --- switched reluctance generator --- capacitance current pulse train control --- voltage ripple --- capacitance current --- feedback coefficient --- distributed architecture --- maximum power point tracking --- sliding mode control --- overvoltage --- permanent magnet synchronous motor (PMSM) --- single artificial neuron goal representation heuristic dynamic programming (SAN-GrHDP) --- single artificial neuron (SAN) --- reinforcement learning (RL) --- goal representation heuristic dynamic programming (GrHDP) --- adaptive dynamic programming (ADP) --- sliding mode observer (SMO) --- permanent magnet synchronous motor (PMSM) --- extended back electromotive force (EEMF) --- position sensorless --- bridgeless converter --- discontinuous conduction mode (DCM) --- high step-up voltage gain --- power factor correction (PFC) --- space mechanism --- multi-clearance --- nonlinear dynamic model --- planetary gears --- vibration characteristics --- new step-up converter --- ultrahigh voltage conversion ratio --- small-signal model --- average-current mode control --- slope compensation --- monodromy matrix --- current mode control --- boost-flyback converter --- explosion-magnetic generator --- plasma accelerator --- current-pulse formation --- DC-DC buck converter --- contraction analysis --- global stability --- matrix norm --- DC micro grid --- efficiency optimization --- variable bus voltage MG --- variable switching frequency DC-DC converters --- centralized vs. decentralized control --- local vs. global optimization --- buck converter --- DC motor --- bifurcations in control parameter --- sliding control --- zero average dynamics --- fixed-point inducting control --- DC-DC converters --- quadratic boost --- maximum power point tracking (MPPT) --- nonlinear dynamics --- subharmonic oscillations --- photovoltaic (PV) --- steel catenary riser --- rigid body rotation --- wave --- the load of suspension point in the z direction --- Cable3D

Plug-in Hybrid Electric Vehicle (PHEV)

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ISBN: 9783039214532 9783039214549 Year: Pages: 230 DOI: 10.3390/books978-3-03921-454-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Climate change, urban air quality, and dependency on crude oil are important societal challenges. In the transportation sector especially, clean and energy efficient technologies must be developed. Electric vehicles (EVs) and plug-in hybrid electric vehicles (PHEVs) have gained a growing interest in the vehicle industry. Nowadays, the commercialization of EVs and PHEVs has been possible in different applications (i.e., light duty, medium duty, and heavy duty vehicles) thanks to the advances in energy storage systems, power electronics converters (including DC/DC converters, DC/AC inverters, and battery charging systems), electric machines, and energy efficient power flow control strategies. This book is based on the Special Issue of the journal Applied Sciences on “Plug-In Hybrid Electric Vehicles (PHEVs)”. This collection of research articles includes topics such as novel propulsion systems, emerging power electronics and their control algorithms, emerging electric machines and control techniques, energy storage systems, including BMS, and efficient energy management strategies for hybrid propulsion, vehicle-to-grid (V2G), vehicle-to-home (V2H), grid-to-vehicle (G2V) technologies, and wireless power transfer (WPT) systems.

Keywords

battery power --- convex optimization --- dynamic programming --- engine-on power --- plug-in hybrid electric vehicle --- simulated annealing --- electric vehicle --- open-end winding --- dual inverter --- voltage vector distribution --- power sharing --- energy management --- range-extender --- CO2 --- air quality --- mobility needs --- LCA --- Paris Agreement --- hybrid energy storage system --- lithium-ion battery --- lithium-ion capacitor --- lifetime model --- power distribution --- state of health estimation --- adaptive neuron-fuzzy inference system (ANFIS) --- group method of data handling (GMDH) --- artificial neural network (ANN) --- electric vehicles (EVs) --- capacity degradation --- lithium-ion battery --- time-delay input --- interleaved multiport converte --- multi-objective genetic algorithm --- hybrid electric vehicles --- losses model --- wide bandgap (WBG) technologies --- Energy Storage systems --- LCA --- Well-to-Wheel --- electric vehicle --- plug-in hybrid --- electricity mix --- consequential --- attributional --- marginal --- system modelling --- energy system --- meta-analysis --- parallel hybrid electric vehicle --- regenerative braking --- fuel consumption characteristics --- energy efficiency --- state of charge --- lithium polymer battery --- electric vehicle --- Plugin Hybrid electric vehicle --- Li-ion battery --- modelling --- measurements --- state of charge --- strong track filter --- modified one-state hysteresis model --- Li(Ni1/3Co1/3Mn1/3)O2 battery --- energy management strategy --- Markov decision process (MDP) --- plug-in hybrid electric vehicles (PHEVs) --- Q-learning (QL) --- reinforcement learning (RL) --- novel propulsion systems --- emerging power electronics --- including wide bandgap (WBG) technology --- emerging electric machines --- efficient energy management strategies for hybrid propulsion systems --- energy storage systems --- life-cycle assessment (LCA)

Neuroproteomics

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ISBN: 9783039281060 9783039281077 Year: Pages: 318 DOI: 10.3390/books978-3-03928-107-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2020-04-07 23:07:08
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The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes.

Keywords

proteomics --- basal ganglia --- synapses --- synapse specificity --- neuronal circuits --- axons --- dendrites --- neurodegeneration --- synapse --- postsynaptic --- proteome --- mass spectrometry --- protein interaction networks --- connectome --- neurodegeneration --- Alzheimer’s disease --- cerebrospinal fluid --- plasma --- serum --- proteomics --- biomarkers --- LC-MS/MS --- cocaine --- addiction --- cytokine --- neuroimmune --- ventral tegmental area --- peptidylglycine ?-amidating monooxygenase --- cilia --- mating --- signal peptide --- prohormone convertase --- carboxypeptidase --- matrix metalloproteinase --- subtilisin --- pherophorin --- morphine --- opioid receptors --- conformational antibody --- analgesia --- GPCR signaling --- phosphorylation --- AMPA receptor complex --- transmembrane AMPA receptor regulatory protein --- synaptic plasticity --- adolescence --- corticosterone --- proteomics --- yohimbine --- progressive ratio --- reinstatement --- ethanol --- nicotinic receptor --- CaMKII --- PKA --- quantitative phosphoproteomics --- mouse --- phosphorylation --- nicotine --- proteomics --- proteome --- mass spectrometry --- Alzheimer’s disease --- protein aggregation --- laser capture microdissection --- splicing --- U1 snRNP --- synapse --- synaptic cleft --- trans-synaptic adhesion --- proximity labeling --- SynCAM --- Cadm --- Receptor-type tyrosine-protein phosphatase zeta --- R-PTP-zeta --- Ptprz1 --- neuroproteome --- drug abuse --- neuropeptidomics --- phosphorylation --- interactome --- cell type --- neuroscience --- proteomics --- mass spectrometry --- neuron --- proximity labeling --- affinity chromatography --- neuroproteomics --- biotinylation --- amphetamine --- spinophilin --- protein phosphatase-1 --- dopamine --- striatum --- mass spectroscopy --- bioinformatics --- FGF14 --- voltage gated channels --- schizophrenia --- autism --- Alzheimer’s Disease --- sex-specific differences --- synaptic plasticity --- cognitive impairment --- excitatory/inhibitory tone --- n/a --- postsynaptic density --- PSD --- parallel reaction monitoring --- PRM --- targeted proteomics --- data-independent acquisition --- DIA --- quantitative mass spectrometry --- n/a

Organs-on-chips

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ISBN: 9783039289172 / 9783039289189 Year: Pages: 262 DOI: 10.3390/books978-3-03928-918-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.

Keywords

microfluidics --- vascularization --- organ-on-a-chip --- vascularized tumor model --- tissue engineering --- microfluidic device --- cell culture --- organ-on-chips --- lung epithelial cell --- surfactant protein --- angiogenesis --- shear stress --- biomechanics --- vessel branching --- beating force --- bio-mechanical property --- cardiac 3D tissue --- human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) --- tissue engineering --- vacuum chuck --- barrier permeability --- epithelial–endothelial interface --- paracellular/transcellular transport --- organ-on-chip --- MEMS --- silicon --- PDMS --- membranes --- cell --- strain --- stress --- lattice light-sheet microscopy --- 3D cell culture system --- functional neuron imaging --- 3D cell culture --- neuronal cells --- SH-SY5Y cells --- image-based screening --- nanogrooves --- neuronal cell networks --- neuronal guidance --- drug metabolism --- biomimetic oxidation --- microfluidics --- organ-on-a-chip --- liver-on-a-chip --- liver-on-a-chip --- drug hepatotoxicity --- drug metabolism --- organoid --- 3D cell culture --- spheroid array --- high-throughput screening --- drug efficacy --- organ-on-a-chip (OOC) --- microfluidic device --- mechanical cue --- shear flow --- compression --- stretch --- strain --- syringe pump --- integrated pump --- passive delivery --- organs-on-chips --- microfluidics --- drug absorption --- fluoroelastomer --- ischemia/reperfusion injury --- thrombolysis --- organ-on-a-chip --- endothelial cell activation --- microfluidics --- microfabrication --- organ-on-a-chip --- trans-epithelial electrical resistance --- multi-culture --- n/a

DNA Replication Stress

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ISBN: 9783039213894 9783039213900 Year: Pages: 368 DOI: 10.3390/books978-3-03921-390-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 16:10:12
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This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.

Keywords

barley --- chromosome --- DNA replication pattern --- EdU --- mutagens --- DNA replication --- DNA damage --- DNA repair --- genome integrity --- A549 cells --- H1299 cells --- heterogeneity --- DNA damage response --- 8-chloro-adenosine --- DNA replication --- S phase --- origin firing --- TopBP1 --- ATR --- DNA fiber assay --- APE2 --- ATR-Chk1 DDR pathway --- Genome integrity --- SSB end resection --- SSB repair --- SSB signaling --- DNA replication stress --- genome stability --- ubiquitin --- replication fork restart --- translesion synthesis --- template-switching --- homologous recombination --- Fanconi Anemia --- G protein-coupled receptor (GPCR) --- aging --- DNA damage --- ?-arrestin --- G protein-coupled receptor kinase (GRK) --- interactome --- G protein-coupled receptor kinase interacting protein 2 (GIT2) --- ataxia telangiectasia mutated (ATM) --- clock proteins --- energy metabolism --- neurodegeneration --- cellular senescence --- ageing --- Alzheimer’s disease --- multiple sclerosis --- Parkinson’s disease --- lipofuscin --- SenTraGorTM (GL13) --- senolytics --- DNA replication --- DNA repair --- DNA damage response --- DNA translocation --- DNA helicase --- superfamily 2 ATPase --- replication restart --- fork reversal --- fork regression --- chromatin remodeler --- C9orf72 --- ALS --- motor neuron disease --- R loops, nucleolar stress --- neurodegeneration --- Difficult-to-Replicate Sequences --- replication stress --- non-B DNA --- Polymerase eta --- Polymerase kappa --- genome instability --- common fragile sites --- Microsatellites --- cancer --- DNA double-strand repair --- premature aging --- post-translational modification --- protein stability --- replication stress --- Werner Syndrome --- Werner Syndrome Protein --- dormant origins --- replicative stress --- replication timing --- DNA damage --- genome instability --- cancer --- Thermococcus eurythermalis --- endonuclease IV --- AP site analogue --- spacer --- DNA repair --- DNA repair --- double strand break repair --- exonuclease 1 --- EXO1 --- mismatch repair --- MMR --- NER --- nucleotide excision repair --- strand displacements --- TLS --- translesion DNA synthesis --- POL? --- mutation frequency --- mutations spectra --- SupF --- mutagenicity --- oxidative stress --- DNA damage --- DNA repair --- replication --- 8-oxoG --- epigenetic --- gene expression --- helicase --- cell cycle checkpoints --- genomic instability --- G2-arrest --- cell death --- repair of DNA damage --- adaptation --- n/a

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