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Novel Molecular Approaches to Target Microbial Virulence

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ISBN: 9783110449501 9783110449617 Year: Pages: 87 DOI: 10.1515/9783110449501 Language: English
Publisher: De Gruyter
Subject: Biotechnology --- Microbiology --- Internal medicine
Added to DOAB on : 2016-01-06 13:06:10
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Microbial infections still represent one of the major causes of mortality and morbidity worldwide. Irrational usage of antimicrobials has lead to increased resistance, causing clinical, social and economical disabilities. Therefore, one of the major challenges of scientists is to develop novel alternative methods to handle infections and reduce resistance and other side effects produced by the actual therapies. The aim of this book is to offer a perspective on novel approaches to handle infections by using naturally-derived products in order to modulate the virulence of pathogens, without the risk of developing resistance. We intend to highlight the utility of microbial, vegetal and animal–derived compounds with potential antimicrobial activity by exploiting their effect on microbial virulence. Furthermore, this book aims to reveal the potential to assimilate recent bio-technological findings, like the usage of nanotechnology as efficient shuttles for stabilizing, improved targeting and the controlled release of natural products in order to efficiently fight infections.

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

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ISBN: 9783038427971 9783038427988 Year: Pages: VIII, 302 DOI: 10.3390/books978-3-03842-798-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-04-06 13:44:18
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Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population.This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.

Polymer Micelles

Authors: --- --- ---
ISBN: 9783038428077 9783038428084 Year: Pages: VIII, 220 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biochemistry
Added to DOAB on : 2018-04-20 15:30:28
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Classically, polymer micelles have been defined as aggregates formed by the self-association of amphiphilic polymers due to the hydrophobic interactions between polymer molecules in water. Practical applications of polymer micelles include as carriers in drug delivery systems, as solubilizers, and as associative thickeners. Polymer micelles that do not fall within the classical definition have recently been reported and reflect important developments in synthesis and analysis. For example, hydrophobic interactions are the classic force driving polymer association, whereas recently, micelles have been formed through interactions such as electrostatics, hydrogen bonds, and coordination bonds. Intermolecular association results in the formation of polymer micelles that are similar to micelles formed from low molecular weight surfactants, whereas unimolecular micelles formed by intramolecular association within a single polymer chain have also been reported, as have stimuli-responsive polymer micelles. It is therefore important to constantly update the information available and our knowledge of polymer micelles. This special issue covers synthesis, characterization, solution properties, association behavior, simulation, and the application of polymer micelles and polymer aggregates. The aim of this issue is to expand our knowledge of polymer micelles by gathering together the latest basic and applied information regarding these supramolecular structures.

Marine Polysaccharides Volume 3

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ISBN: 9783038429012 9783038429029 Year: Volume: 3 Pages: X, 564 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-04-24 09:32:36
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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Marine Polysaccharides Volume 2

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ISBN: 9783038428992 9783038429005 Year: Volume: 2 Pages: X, 290 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-04-24 09:35:54
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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Marine Polysaccharides Volume 1

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ISBN: 9783038428978 9783038428985 Year: Volume: 1 Pages: VIII, 224 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-04-24 09:38:37
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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Selected Papers from 2017 International Conference on Micro/Nanomachines

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ISBN: 9783038970811 9783038970828 Year: Pages: VIII, 170 DOI: 10.3390/books978-3-03897-082-8 Language: english
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences --- Mechanical Engineering
Added to DOAB on : 2018-08-09 17:08:18
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The 2017 International Conference on Micro/Nanomachines (http://www.icmnm.org/) was held in Wuhan, China, 25–28 August, 2017. Micro/nanomotors (MNMs), which are defined as micro/nanodevices capable of converting energy into autonomous motion, can be used to pick up, transport, and release various cargoes within a liquid medium. They have important potential applications, for example, in drug delivery, biosensors, protein and cell separation, microsurgeries, and environment remediation. MNMs can be classified into two categories, according to their propulsion mechanism. In this respect, self-propelled MNMs are capable of moving autonomously without external intervention, but they either require toxic fuel or have a short lifespan. MNMs actuated by external fields, such as light, magnetic field, and acoustic waves, are not subject to these problems, do not require toxic fuels, nor give rise to by-products during the motion process. For both self-propelled and field-actuated MNMs, there is still a long way to go before we reach practical applications. The future development of MNMs should be focused on improving the energy conversion efficiency through structure optimization, exploring new propulsion mechanisms and endowing MNMs with environmental responses for self-navigation, detection, and specific operations. In this way, MNMs will approach their practical application in biomedicine, environment treatment, microengineering, etc.

Advances in Marine Chitin and Chitosan II, 2017

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ISBN: 9783038426776 9783038426783 Year: Pages: 410 DOI: 10.3390/books978-3-03842-678-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-01-16 09:37:31
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As a result of our call in 2014 for submissions to a Special Issue, Advances in Marine Chitin and Chitosan in Marine Drugs, we are now pleased to tell you that this issue has been published. Twenty high class papers were included in this issue, which we now plan to publish as a book. In addition we now seek to publish a further Special Issue, Advances in Marine Chitin and Chitosan II, 2017, in Marine Drugs. As before, we plan to produce a strong, very exciting issue that will encompass breakthroughs in high value, scientific and industrial chitin and chitosan research. Despite significant advances in chitin and chitosan research since the 1970s, current overviews in recent publications involving chitin and chitosan research advances need reporting.

Translocator Protein (TSPO)

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ISBN: 9783038427575 9783038427582 Year: Pages: 176 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-03-16 13:21:14
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The high number of papers submitted and ultimately accepted for publication in this special issue attests the great amount of research being conducted on TSPO and its role in living cells. Thus, TSPO has become an extremely attractive subcellular biomark for the early detection of disease states overexpressing this protein and for the selective delivery to mitochondria of drugs and probes. Moreover, the effort in the design and synthesis of new, more specific and effective TSPO ligands proves to be very valuable. All these topics have been addressed in the special issue.

Electrospun and Electrosprayed Formulations for Drug Delivery

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ISBN: 9783038979128 9783038979135 Year: Pages: 190 DOI: 10.3390/books978-3-03897-913-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 10:09:00
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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

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