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Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population.This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.

Pharmaceutical Sciences --- Canada --- Drug Metabolism --- Drug Delivery --- Pharmacokinetics --- Pharmacology

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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Chitosan --- Alginate --- Agar --- Carrageenans --- Exopolysaccharides --- Chemical modification --- Drug delivery --- Gene delivery

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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Chitosan --- Alginate --- Agar --- Carrageenans --- Exopolysaccharides --- Chemical modification --- Drug delivery --- Gene delivery

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As a result of our call in 2014 for submissions to a Special Issue, Advances in Marine Chitin and Chitosan in Marine Drugs, we are now pleased to tell you that this issue has been published. Twenty high class papers were included in this issue, which we now plan to publish as a book. In addition we now seek to publish a further Special Issue, Advances in Marine Chitin and Chitosan II, 2017, in Marine Drugs. As before, we plan to produce a strong, very exciting issue that will encompass breakthroughs in high value, scientific and industrial chitin and chitosan research. Despite significant advances in chitin and chitosan research since the 1970s, current overviews in recent publications involving chitin and chitosan research advances need reporting.

chitin --- chitosan --- chito-oligosaccharide --- glucosamine --- N-acetyl-D-glucosamine --- chemical modification --- controlled drug delivery --- hydrogels --- tissue engineering --- nanomaterial

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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

electrospinning --- Eudragit --- nanofibers --- drug release --- carvedilol --- poly (vinylpyrrolidone-co-vinyl acetate) --- high-speed electrospinning --- high-shear mixing --- homogenization --- Raman mapping --- sieve analysis --- amorphous composite --- coaxial electrospinning --- fast dissolution --- insoluble drug --- solid dispersion --- electrospinning --- parameters --- drug delivery --- applications --- solid dispersion --- aqueous solubility enhancement --- amorphous --- crystalline --- oral drug delivery --- electrospinning --- cyclodextrin --- electrospinning --- drug delivery --- nanofibers --- cyclodextrin-inclusion complexes --- essential oils --- electrospun nanofibers --- poly-cyclodextrin --- antibacterial --- antibiotics --- PMVE/MA --- electrospinning --- nanofibers --- capsaicin --- psoriasis --- TRPV1 --- PCL --- electrospinning --- combination therapy --- photothermal therapy --- NIR-triggered drug release --- xanthan gum --- electrospinning --- gallic acid --- permeability --- electrospinning --- tissue engineering --- drug delivery