Search results: Found 4

Listing 1 - 4 of 4
Sort by
Cancer Metabolomics 2018

Authors: --- ---
ISBN: 9783039213450 / 9783039213467 Year: Pages: 184 DOI: 10.3390/books978-3-03921-346-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development

Author:
ISBN: 9783039217083 / 9783039217090 Year: Pages: 176 DOI: 10.3390/books978-3-03921-709-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.

Benefits of Resveratrol Supplementation

Authors: ---
ISBN: 9783039212750 / 9783039212767 Year: Pages: 260 DOI: 10.3390/books978-3-03921-276-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

In recent years, great attention has been paid to polyphenols due to their positive effects on health. One of the most widely-studied phenolic compounds is resveratrol. This molecule, which is naturally present in some foods, shows beneficial effects on various physiological and biochemical processes, thus representing a potential tool for the prevention or the treatment of diseases highly prevalent in our society. Several of these beneficial effects have been observed in human beings, but others only in pre-clinical studies so far, and therefore, it is mandatory to continue with the scientific research in this field. Indeed, new knowledge concerning these issues could enable the development of novel functional foods or nutraceuticals, incorporating resveratrol, suitable for preventing or treating diseases such as cancer, cardiovascular diseases, obesity, dislipemia, insulin resistance and diabetes, liver diseases, etc.

Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing

Author:
ISBN: 9783039215744 / 9783039215751 Year: Pages: 278 DOI: 10.3390/books978-3-03921-575-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.

Keywords

artificial self-sufficient P450 --- bioplastics --- dodecanoic acid --- Nylon 12 --- ?-aminododecanoic acid --- immobilization --- fluorescein diacetate --- polyurethane foam --- biofilm --- total enzymatic activity --- biocatalysis --- Combi-CLEAs --- cascade reactions --- immobilization --- Myceliophthora --- glyoxal oxidase --- 5-hydroxymethylfurfural --- aerobic methane bioconversion --- bioreactor --- string film reactor --- mass transfer performance --- cross-linked enzyme aggregate --- amyloglucosidase --- magnetic nanoparticles --- bovine serum albumin --- polyethyleneimine --- starch hydrolysis --- Eversa --- interfacial activation --- lipase immobilization --- enzyme stabilization --- enzyme modulation --- metabolic engineering --- synthetic biology --- 3-hydroxypropionic acid --- microbial production --- fatty acid synthesis --- acetate --- redox enzymes --- FTIR spectroscopy --- small molecules --- Corynebacterium glutamicum --- Pvgb --- tunable expression system --- expression vectors --- synthetic biology --- Vitreoscilla --- vgb --- biocatalysts --- biocatalytic reaction --- Methylosinus sporium strain 5 --- soluble methane monooxygenase --- C–H activation --- O2 activation --- synthetic biology --- metabolic engineering --- microbial cell factory --- synthetic metabolic pathways --- mannose --- magnetic nanoparticles --- immobilization --- whole cell --- specific recognition --- 12-hydroxydodecanoic acid --- dodecanoic acid --- CYP153A --- whole-cell biotransformation --- Candida antarctica Lipase B --- transesterification --- polymer functionalization --- tetraethylene glycol --- poly(ethylene glycol) --- hydrogenase --- bio-hydrogen --- chemicals addition --- review --- (?)-?-bisabolol --- mevalonate (MVA) --- mevalonate kinase 1 --- Methanosarcina mazei --- fed-batch fermentation --- monoterpene --- prokaryotic microbial factory --- metabolic engineering --- MEP pathway --- MEV pathway --- n/a

Listing 1 - 4 of 4
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (4)


License

CC by-nc-nd (4)


Language

eng (4)


Year
From To Submit

2019 (4)