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Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

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ISBN: 9783038427971 9783038427988 Year: Pages: VIII, 302 DOI: 10.3390/books978-3-03842-798-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-04-06 13:44:18
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Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population.This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.

Glocal Pharma

Authors: --- ---
Book Series: Global Connections ISBN: 9781315585185 9781472481634 9781317126799 9781317126782 9781317126775 Year: DOI: 10.4324/9781315585185 Language: English
Publisher: Taylor & Francis
Subject: Sociology
Added to DOAB on : 2019-11-08 11:21:23
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The Open Access version of this book, available at http://www.tandfebooks.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. An exploration of how global pharmaceutical products are localized - of what happens when they become ‘glocal’ - this book examines the tensions that exist between a global pharmaceutical market and the locally bounded discourses and regulations encountered as markets are created for new drugs in particular contexts. Employing the case study of the emergence, representation and regulation of Viagra in the Swedish market, Glocal Pharma offers analyses of commercial material, medical discourses and legal documents to show how a Swedish, Viagra-consuming subject has been constructed in relation to the drug and how Viagra is imagined in relation to the Swedish man. Engaging with debates about pharmaceuticalization, the authors consider the ways in which new identities are created around drugs, the redefinition of health problems as sites of pharmaceutical treatment and changes in practices of governance to reflect the entrance of pharmaceuticals to the market. With attention to ‘local’ contexts, it reveals elements in the nexus of pharmaceutcalization that are receptive to cultural elements as new products become embedded in local markets. An empirically informed study of the the ways in which the presence of a drug can alter the concept of a disease and its treatment, understandings of who suffers from it and how to cure it - both locally and internationally - this book will appeal to scholars of sociology and science and technology studies with interests in globalization, pharmaceuticals, gender and the sociology of medicine.

Keywords

swedish --- health --- care --- system --- erectile --- dysfunction --- pharmaceutical --- benefits --- scheme --- lifestyle

FTO (Freedom to Operate) in the Pharmaceutical Industry

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Book Series: Munich Intellectual Property Law Center - MIPLC ISBN: 9783845294018 Year: Volume: 34 DOI: http://dx.doi.org/10.5771/9783845294018 Language: English
Publisher: Nomos Verlagsgesellschaft mbH & Co. KG
Subject: Law
Added to DOAB on : 2018-11-05 12:58:39
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FTO licensing in the pharmaceutical industry deserves special consideration because of the large economic scale of the market, expensive cost of R&D, extremely low success rate, and easy duplication of the drug. Taking these unique aspects into consideration, the author first explaines how to perform a good FTO search and conclude an appropriate FTO licensing agreement, and then points out two issues; (i) the issue of FTO licensing and EU competition, especially the unreasonable application of the Guideline, and (ii) the issue of FTO licensing and differentiating between a bio venture company and a pharmaceutical company. Solutions for these issues are proposed.

Healthcare Biotechnology

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ISBN: 9781439894125 Year: Pages: 689 DOI: 10.1201/9781439894125 Language: English
Publisher: Taylor & Francis
Subject: Business and Management --- Medicine (General)
Added to DOAB on : 2020-09-23 00:05:37
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Foreseeing and planning for all of the possibilities and pitfalls involved in bringing a biotechnology innovation from inception to widespread therapeutic use takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures. Unfortunately there has been a dearth of resources for this aspect of the field.

Model-Based Tools for Pharmaceutical Manufacturing Processes

Authors: --- --- ---
ISBN: 9783039284245 9783039284252 Year: Pages: 188 DOI: 10.3390/books978-3-03928-425-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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The Special Issue on “Model-Based Tools for Pharmaceutical Manufacturing Processes” will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This book provides a collection of nine papers on original advances in the model-based process unit, system-level, quality-by-design under uncertainty, and decision-making applications of pharmaceutical manufacturing processes.

Pharmacist Services

Authors: ---
ISBN: 9783039217540 9783039217557 Year: Pages: 436 DOI: 10.3390/books978-3-03921-755-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Pharmacy and materia medica
Added to DOAB on : 2019-12-09 11:49:16
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The overall goal of this book is to give the reader a state-of-the-art synopsis of the pharmacist services domain. To accomplish this goal, the authors have addressed the social, psychosocial, political, legal, historic, clinical, and economic factors that are associated with pharmacist services. In this book, you will gain cutting-edge insights from learning about the research of experts throughout the world. The findings have relevance for enhancing pharmacist professionalism, pharmacist practice, and the progression of pharmacist services in the future.

Keywords

ambulatory care --- pharmacy practice faculty --- pharmacy learners --- clinical practice --- pharmacist services --- community pharmacy practice --- dispensing --- counselling --- pharmaceutical intervention --- pharmaceutical care --- observation --- immunization programs --- mobile health units --- experiential learning --- billing --- healthy people 2020 --- pharmacy --- emergency unit --- health workers --- cystic fibrosis --- pharmacists --- pharmacy services, medication management --- medication use burden --- travel --- immunization --- vaccination --- pharmacist --- community pharmacy --- pharmacy intern --- student pharmacist --- primary care --- interprofessional --- federally qualified health center --- serviced marketing --- design thinking --- medication synchronization --- community pharmacists --- innovation science --- adherence --- competitive advantage --- age disparities --- gender disparities --- job satisfaction --- job-related preferences --- pharmacist workforce --- pharmacists --- pharmacy education --- interprofessional practice and education --- community pharmacy --- medication therapy management --- medication-related problems --- medication discrepancies --- continuity of patient care --- cost avoidance --- Comprehensive Medication Management --- pharmaceutical care --- primary health care --- chronic diseases --- clinical results --- naltrexone --- opioid use disorder --- implementation --- service process --- regulatory --- community pharmacy --- pharmacist services --- opioid --- communication --- naloxone --- misuse --- disposal --- safety --- counseling --- comprehensive medication review --- community pharmacy --- collaboration --- community pharmacy --- pharmaceutical care --- medication therapy management --- pharmacy practice --- pharmacy education --- grants --- pharmacy benefit manager (PBM) --- ethics --- pharmaceutical regulation --- health care policy --- decision-making --- organizations --- ethical models --- code of ethics --- pharmacist --- adverse drug events --- brown bag --- pharmacy --- medication reconciliation --- pharmacy clinical services --- comprehensive medication management services --- medication experience --- pharmaceutical care practice --- documentation --- focus groups --- community pharmacy --- retail clinics --- pharmacists --- nurse practitioners --- interprofessional training --- primary care --- healthcare access --- community pharmacy --- pharmacist services --- wellness programs --- medication adherence --- quality measurement/benchmarking --- multiple chronic conditions --- CMS Star rating --- chronic kidney disease --- interprofessional care --- quality assurance --- pharmacy communication --- cue orientation --- focus group interviews --- Denmark --- transitions in care --- pharmacist --- medication therapy problems --- medication safety --- comprehensive medication management --- readmissions --- intention --- medication therapy management --- pharmacy services --- South Asian --- theory of planned behavior. --- pharmacist services --- community pharmacy --- care plan --- compensation --- primary health care --- information sharing --- qualitative research --- comparative case study --- value --- human papilloma virus --- HPV vaccination --- pharmacy --- coordinated care --- history of pharmacy --- 20th century history --- 21st century history --- community pharmacy services --- pharmacy education --- pharmacist --- services marketing --- management --- value-added services --- community-based pharmacy --- community-based pharmacist practitioners --- community pharmacy services --- health policy --- interrupted time series analysis --- medication reconciliation --- mental health care --- pharmacy staff --- mental health first aid --- mental illness --- pharmacist roles --- n/a --- collaborative practice --- clinical pharmacy --- advanced practice pharmacist provider

Pharmaceutical Crystals

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ISBN: 9783039287123 / 9783039287130 Year: Pages: 148 DOI: 10.3390/books978-3-03928-713-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2020-06-09 16:38:57
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The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.

Environmental Fate of Emerging Organic Micro-Contaminants

Authors: ---
ISBN: 9783039213672 9783039213689 Year: Pages: 128 DOI: 10.3390/books978-3-03921-368-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Environmental Sciences
Added to DOAB on : 2019-12-09 11:49:15
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The toxicity and fate of pharmaceuticals and other emerging micro-organic contaminants in the natural and built environments have been the focus of much research over the last twenty years. Particular focus has recently centred on the fate of antimicrobial chemicals, including antibiotics and antifungals. The occurrence of such chemicals in the environment is thought to contribute to the selection of resistance in exposed microorganisms.This Special Issue (SI) brings together a broad range of recent advances in the field of emerging micro-organic contaminants, ranging from medicinal contaminants to industrial chemicals in the environment. Notably, these range from chemical extraction and large-scale analysis to adverse effects on non-target aquatic organisms and potential risk to humans via contaminated foodstuffs. Additionally, this Special Issue also presents novel contaminant treatment/degradation methods of both physical and biological nature.

Recent Progress in Solid Dispersion Technology

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ISBN: 9783039215010 9783039215027 Year: Pages: 204 DOI: 10.3390/books978-3-03921-502-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Drug Metabolism, Pharmacokinetics and Bioanalysis

Authors: ---
ISBN: 9783038979166 9783038979173 Year: Pages: 230 DOI: 10.3390/books978-3-03897-917-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Keywords

procainamide --- N-acetylprocainamide --- ultra-high-pressure liquid chromatography --- rat --- plasma --- pharmacokinetics --- adalimumab --- immunoprecipitation --- liquid chromatography-quadrupole TOF MS --- bioanalysis --- GB3 --- Fabry disease --- LC-QTOF-MS/MS --- B6 --- 129-Glatm1Kul/J --- cytochrome P450 --- drug interaction --- liquid chromatography-tandem mass spectrometry --- organic anion transporting polypeptide --- pharmacokinetics --- Korean red ginseng extract --- metformin --- diabetes --- drug interaction --- pharmacokinetics --- efficacy --- ethyl glucuronide --- hair --- HPLC-MS/MS --- AUDIT score --- alcohol addiction --- eurycomanone --- Eurycoma longifolia --- bioavailability --- pharmacokinetic --- anthraquinone --- glycoside --- aglycone --- LC-MS/MS --- plasma --- protein precipitation --- loxoprofen --- CYP --- UGT --- human liver microsomes --- LC-HR/MS --- mematine --- drug interaction --- liquid chromatography-tandem mass spectrometry --- pharmacokinetics --- biopharmaceuticals --- drying technology --- protein stability --- bioavailability --- pharmacokinetics --- DA-9805 --- saikosaponin a --- paeonol --- imperatorin --- pharmacokinetics --- brain distribution --- Osthenol --- CYP --- UGT --- human liver microsomes --- glucuronidation --- Stauntonia hexaphylla leaf extract --- YRA-1909 --- pharmacokinetics --- chlorogenic acid --- neochlorogenic acid --- cryptochlorogenic acid --- caffeic acid --- caffeic acid O-glucuronides --- LC-MS/MS --- aceclofenac --- diclofenac --- esomeprazole --- pharmacokinetics --- gastric ulcer --- acetyl tributyl citrate --- pharmaceutical excipient --- pharmacokinetics --- metabolic stability --- plasma

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