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Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population.This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.
Pharmaceutical Sciences --- Canada --- Drug Metabolism --- Drug Delivery --- Pharmacokinetics --- Pharmacology
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The Open Access version of this book, available at http://www.tandfebooks.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. An exploration of how global pharmaceutical products are localized - of what happens when they become ‘glocal’ - this book examines the tensions that exist between a global pharmaceutical market and the locally bounded discourses and regulations encountered as markets are created for new drugs in particular contexts. Employing the case study of the emergence, representation and regulation of Viagra in the Swedish market, Glocal Pharma offers analyses of commercial material, medical discourses and legal documents to show how a Swedish, Viagra-consuming subject has been constructed in relation to the drug and how Viagra is imagined in relation to the Swedish man. Engaging with debates about pharmaceuticalization, the authors consider the ways in which new identities are created around drugs, the redefinition of health problems as sites of pharmaceutical treatment and changes in practices of governance to reflect the entrance of pharmaceuticals to the market. With attention to ‘local’ contexts, it reveals elements in the nexus of pharmaceutcalization that are receptive to cultural elements as new products become embedded in local markets. An empirically informed study of the the ways in which the presence of a drug can alter the concept of a disease and its treatment, understandings of who suffers from it and how to cure it - both locally and internationally - this book will appeal to scholars of sociology and science and technology studies with interests in globalization, pharmaceuticals, gender and the sociology of medicine.
swedish --- health --- care --- system --- erectile --- dysfunction --- pharmaceutical --- benefits --- scheme --- lifestyle
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FTO licensing in the pharmaceutical industry deserves special consideration because of the large economic scale of the market, expensive cost of R&D, extremely low success rate, and easy duplication of the drug. Taking these unique aspects into consideration, the author first explaines how to perform a good FTO search and conclude an appropriate FTO licensing agreement, and then points out two issues; (i) the issue of FTO licensing and EU competition, especially the unreasonable application of the Guideline, and (ii) the issue of FTO licensing and differentiating between a bio venture company and a pharmaceutical company. Solutions for these issues are proposed.
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Foreseeing and planning for all of the possibilities and pitfalls involved in bringing a biotechnology innovation from inception to widespread therapeutic use takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures. Unfortunately there has been a dearth of resources for this aspect of the field.
Biotechnology --- Biopharmaceutics --- Healthcare Management --- BUSINESS/MANAGEMENT --- PHARMACEUTICAL --- BIOSCIENCE --- SCI-TECH --- BIOMEDICALSCIENCE --- INFORMATIONSCIENCE --- STM --- Biodrug Research --- Bioeconomy --- Biolicensing --- Biomanufacturing --- Intellectual Property Management
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The Special Issue on “Model-Based Tools for Pharmaceutical Manufacturing Processes” will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This book provides a collection of nine papers on original advances in the model-based process unit, system-level, quality-by-design under uncertainty, and decision-making applications of pharmaceutical manufacturing processes.
pharmaceutical processes --- flexibility analysis --- probabilistic design space --- global optimization --- model integration --- flowsheet modeling --- sensitivity analysis --- continuous manufacturing --- wet granulation --- Amoxicillin --- enzymatic synthesis --- non-isothermal modelling --- parameter estimation --- dynamic optimisation --- enzymatic reaction --- reversible reaction --- dynamic modelling --- pyrimidine-nucleoside phosphorylase --- spectroscopic assay --- process kinetics --- ODE model --- process design --- single-use technology --- parenteral manufacturing --- MATLAB Production Server --- software development --- multi-objective decision-making --- robust process design --- batch-to-batch variation --- parametric probability-box --- point estimate method --- pharmaceutical manufacturing --- freeze-drying --- quality by design --- pharmaceutical manufacturing --- polynomial chaos --- global sensitivity analysis --- spray drying --- process modeling --- return on investment --- diffusion of innovation --- residence time distribution --- continuous stirred tank reactor --- bypassing --- Fourier analysis --- continuous manufacturing --- n/a
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The overall goal of this book is to give the reader a state-of-the-art synopsis of the pharmacist services domain. To accomplish this goal, the authors have addressed the social, psychosocial, political, legal, historic, clinical, and economic factors that are associated with pharmacist services. In this book, you will gain cutting-edge insights from learning about the research of experts throughout the world. The findings have relevance for enhancing pharmacist professionalism, pharmacist practice, and the progression of pharmacist services in the future.
ambulatory care --- pharmacy practice faculty --- pharmacy learners --- clinical practice --- pharmacist services --- community pharmacy practice --- dispensing --- counselling --- pharmaceutical intervention --- pharmaceutical care --- observation --- immunization programs --- mobile health units --- experiential learning --- billing --- healthy people 2020 --- pharmacy --- emergency unit --- health workers --- cystic fibrosis --- pharmacists --- pharmacy services, medication management --- medication use burden --- travel --- immunization --- vaccination --- pharmacist --- community pharmacy --- pharmacy intern --- student pharmacist --- primary care --- interprofessional --- federally qualified health center --- serviced marketing --- design thinking --- medication synchronization --- community pharmacists --- innovation science --- adherence --- competitive advantage --- age disparities --- gender disparities --- job satisfaction --- job-related preferences --- pharmacist workforce --- pharmacists --- pharmacy education --- interprofessional practice and education --- community pharmacy --- medication therapy management --- medication-related problems --- medication discrepancies --- continuity of patient care --- cost avoidance --- Comprehensive Medication Management --- pharmaceutical care --- primary health care --- chronic diseases --- clinical results --- naltrexone --- opioid use disorder --- implementation --- service process --- regulatory --- community pharmacy --- pharmacist services --- opioid --- communication --- naloxone --- misuse --- disposal --- safety --- counseling --- comprehensive medication review --- community pharmacy --- collaboration --- community pharmacy --- pharmaceutical care --- medication therapy management --- pharmacy practice --- pharmacy education --- grants --- pharmacy benefit manager (PBM) --- ethics --- pharmaceutical regulation --- health care policy --- decision-making --- organizations --- ethical models --- code of ethics --- pharmacist --- adverse drug events --- brown bag --- pharmacy --- medication reconciliation --- pharmacy clinical services --- comprehensive medication management services --- medication experience --- pharmaceutical care practice --- documentation --- focus groups --- community pharmacy --- retail clinics --- pharmacists --- nurse practitioners --- interprofessional training --- primary care --- healthcare access --- community pharmacy --- pharmacist services --- wellness programs --- medication adherence --- quality measurement/benchmarking --- multiple chronic conditions --- CMS Star rating --- chronic kidney disease --- interprofessional care --- quality assurance --- pharmacy communication --- cue orientation --- focus group interviews --- Denmark --- transitions in care --- pharmacist --- medication therapy problems --- medication safety --- comprehensive medication management --- readmissions --- intention --- medication therapy management --- pharmacy services --- South Asian --- theory of planned behavior. --- pharmacist services --- community pharmacy --- care plan --- compensation --- primary health care --- information sharing --- qualitative research --- comparative case study --- value --- human papilloma virus --- HPV vaccination --- pharmacy --- coordinated care --- history of pharmacy --- 20th century history --- 21st century history --- community pharmacy services --- pharmacy education --- pharmacist --- services marketing --- management --- value-added services --- community-based pharmacy --- community-based pharmacist practitioners --- community pharmacy services --- health policy --- interrupted time series analysis --- medication reconciliation --- mental health care --- pharmacy staff --- mental health first aid --- mental illness --- pharmacist roles --- n/a --- collaborative practice --- clinical pharmacy --- advanced practice pharmacist provider
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The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.
pharmaceutical cocrystal --- melting diagram --- liquid assisted grinding --- adefovir dipivoxil --- dicarboxylic acid --- Crystal structure --- Imidazole --- Benzodioxole --- Semicarbazone --- DFT --- famoxadone --- solvent-mediated polymorphic transformation --- hydrogen-bond-acceptance ability --- crystal structure analysis --- structure determination from powder diffraction data --- salt optimization --- hydrate --- ondansetron --- hygroscopicity --- dehydration --- physicochemical properties --- cocrystal --- solution crystallization --- Raman spectroscopy --- on-line monitoring --- cocrystal formation --- cocrystal --- famotidine --- malonic acid --- crystal structure --- solubility --- hepatitis B --- HBV --- pharmaceutical crystals --- 3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one --- 1H-indole --- pyrimidin-4(3H)-one --- hydrogen bond --- Hirshfeld surface analysis --- molecular docking study --- Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt --- DFT study --- HOMO-LUMO --- reactivity descriptors --- hydrogen bonding --- carbamazepine --- photostability --- polymorphs --- cocrystal --- succinic acid --- saccharin --- ticagrelor --- crystal structure --- crystal habit --- solubility --- dissolution --- n/a
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The toxicity and fate of pharmaceuticals and other emerging micro-organic contaminants in the natural and built environments have been the focus of much research over the last twenty years. Particular focus has recently centred on the fate of antimicrobial chemicals, including antibiotics and antifungals. The occurrence of such chemicals in the environment is thought to contribute to the selection of resistance in exposed microorganisms.This Special Issue (SI) brings together a broad range of recent advances in the field of emerging micro-organic contaminants, ranging from medicinal contaminants to industrial chemicals in the environment. Notably, these range from chemical extraction and large-scale analysis to adverse effects on non-target aquatic organisms and potential risk to humans via contaminated foodstuffs. Additionally, this Special Issue also presents novel contaminant treatment/degradation methods of both physical and biological nature.
chitosan --- Pseudomonas putida --- immobilization --- dye decolorization --- degradation --- biosorption --- wastewater --- qPCR --- tetracyclines --- beta-lactams --- ARGs --- Escherichia coli --- water quality --- Membrane Bioreactor --- GAC-biofilter --- sewage treatment --- micropollutants --- pharmaceutical residues --- activated carbon --- picolinic acid --- biodegradation --- Rhodococcus --- 6-hydroxypicolinic acid --- pharmaceuticals --- organic pollutants --- liquid chromatography tandem mass spectrometry --- validation --- global monitoring --- vitellogenin (VTG) --- crustacean --- di(2-ethylhexyl) phthalate (DEHP) --- bisphenol A (BPA) --- irgarol --- espresso coffee machine extraction --- pressurized hot water extraction --- pharmaceuticals --- antibiotics --- hormones --- sewage sludge --- ion suppression --- UPLC MS/MS --- basic buffer --- veterinary drug --- residue --- shrimp --- mass spectrometry --- risk assessment --- perfluorinated compounds --- coagulation --- ozone --- chlorination --- activated carbon --- n/a --- ethyl tert-butyl ether --- ETBE biodegradation --- bacterial community --- polluted aquifer --- fuel oxygenates --- ethB gene
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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
bicaludamide --- poloxamer --- evaporation --- spray drying --- dissolution enhancement --- nanoaggregates --- self-assembly --- solid dispersion --- classification --- manufacturing methods --- bioavailability --- anticancer drugs --- amorphous --- solid dispersion --- molecular complex --- rebamipide --- polymer --- interaction --- stability --- characterization --- continuous processing --- granulation --- process development --- polyelectrolytes --- amorphous solid dispersions --- hot melt extrusion --- polyelectrolyte excipient matrix --- pharmaceutical glass --- crystallization tendency --- crystallization --- nucleation --- milling --- accelerated stability test --- enrofloxacin --- ciprofloxacin --- amorphous solid dispersion --- amorphous polymeric salt --- polymer --- ball milling --- solubility --- dissolution --- mesoporous --- poorly soluble drugs --- solubility enhancement --- solid dispersion --- amorphisation --- spray drying --- solid dispersions --- miscibility --- solubility --- thermodynamic modeling --- phase diagram --- molecular dynamics simulation --- thermal analysis --- spectroscopic techniques --- solid dispersion --- tadalafil --- Wood’s apparatus --- intrinsic dissolution rate --- Weibull dissolution model --- dissolution rate
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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
procainamide --- N-acetylprocainamide --- ultra-high-pressure liquid chromatography --- rat --- plasma --- pharmacokinetics --- adalimumab --- immunoprecipitation --- liquid chromatography-quadrupole TOF MS --- bioanalysis --- GB3 --- Fabry disease --- LC-QTOF-MS/MS --- B6 --- 129-Glatm1Kul/J --- cytochrome P450 --- drug interaction --- liquid chromatography-tandem mass spectrometry --- organic anion transporting polypeptide --- pharmacokinetics --- Korean red ginseng extract --- metformin --- diabetes --- drug interaction --- pharmacokinetics --- efficacy --- ethyl glucuronide --- hair --- HPLC-MS/MS --- AUDIT score --- alcohol addiction --- eurycomanone --- Eurycoma longifolia --- bioavailability --- pharmacokinetic --- anthraquinone --- glycoside --- aglycone --- LC-MS/MS --- plasma --- protein precipitation --- loxoprofen --- CYP --- UGT --- human liver microsomes --- LC-HR/MS --- mematine --- drug interaction --- liquid chromatography-tandem mass spectrometry --- pharmacokinetics --- biopharmaceuticals --- drying technology --- protein stability --- bioavailability --- pharmacokinetics --- DA-9805 --- saikosaponin a --- paeonol --- imperatorin --- pharmacokinetics --- brain distribution --- Osthenol --- CYP --- UGT --- human liver microsomes --- glucuronidation --- Stauntonia hexaphylla leaf extract --- YRA-1909 --- pharmacokinetics --- chlorogenic acid --- neochlorogenic acid --- cryptochlorogenic acid --- caffeic acid --- caffeic acid O-glucuronides --- LC-MS/MS --- aceclofenac --- diclofenac --- esomeprazole --- pharmacokinetics --- gastric ulcer --- acetyl tributyl citrate --- pharmaceutical excipient --- pharmacokinetics --- metabolic stability --- plasma
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