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Vitamin E

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ISBN: 9783038429050 9783038429067 Year: Pages: VIII, 150 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2018-05-22 09:52:09
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Vitamin E is the major lipid-soluble antioxidant in the cell antioxidant system and is exclusively obtained from the diet. In 1922, vitamin E was discovered as a dietary factor essential for reproduction in rats. Meanwhile, vitamin E has revealed many more important molecular properties, such as the scavenging of reactive oxygen and nitrogen species with consequent prevention of the oxidative damage associated with many diseases. In addition, the modulation of signal transduction and gene expression in antioxidant and non-antioxidant manners was shown for vitamin E.This Special Issue highlights some of the recent advances in vitamin E research, showing on the one hand the status quo and providing, on the other hand, new insights into functions and physiological relevance. Thus, the current knowledge of tocochromanol biosynthesis in plants and future challenges regarding the understanding of its regulation are presented. Another paper describes the fate of vitamin E in the human gastrointestinal lumen during digestion. During the metabolism of vitamin E, the long-chain metabolites 13’-hydroxychromanol and 13’-carboxychromanol are formed by oxidative modification of the side-chain. Their occurrence in human serum indicates a physiological relevance. Another paper describes the membrane distribution of α-tocopherol in brain regions of adult rhesus monkeys, also looking for associations between membrane α-tocopherol and the content of polyunsaturated fatty acids.

Heterogeneity, High Performance Computing, Self-Organization and the Cloud

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Book Series: Palgrave Studies in Digital Business & Enabling Technologies ISBN: 9783319760377 9783319760384 Year: Pages: 165 DOI: https://doi.org/10.1007/978-3-319-76038-4 Language: English
Publisher: Palgrave Macmillan Grant: European Commission; Irish Centre for Cloud Computing and Commerce
Subject: Business and Management --- Computer Science
Added to DOAB on : 2018-07-20 18:56:40
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This open access book addresses the most recent developments in cloud computing such as HPC in the Cloud, heterogeneous cloud, self-organising and self-management, and discusses the business implications of cloud computing adoption. Establishing the need for a new architecture for cloud computing, it discusses a novel cloud management and delivery architecture based on the principles of self-organisation and self-management. This focus shifts the deployment and optimisation effort from the consumer to the software stack running on the cloud infrastructure. It also outlines validation challenges and introduces a novel generalised extensible simulation framework to illustrate the effectiveness, performance and scalability of self-organising and self-managing delivery models on hyperscale cloud infrastructures. It concludes with a number of potential use cases for self-organising, self-managing clouds and the impact on those businesses.

Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease

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ISBN: 9783038972402 9783038972419 Year: Pages: 238 DOI: 10.3390/books978-3-03897-241-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health --- Therapeutics
Added to DOAB on : 2018-10-16 10:00:26
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Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features. The diagnosis of MRC disorders can be complex, and requires a coordinated interplay of a number of disciplines. However, biochemical determination of metabolites in blood, cerebral spinal fluid (CSF) and/or urine are generally considered to be first-line investigations for the diagnosis of these disorders, although they lack sensitivity and specificity. Furthermore, there is a lack of consensus on the overall utility of monitoring other biochemical parameters, which may be of diagnostic value. For example, although oxidative stress may contribute to the pathogenesis of mitochondrial disorders, few centers monitor this as part of their diagnostic repertoire. Therefore, the purpose of this Special Issue was to highlight potential biomarkers of mitochondrial disease and to discuss the appropriateness of biochemical markers to monitor disease progression and therapeutic intervention.

Nutrition and Liver Disease

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ISBN: 9783038429234 9783038429241 Year: Pages: X, 148 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Medicine (General)
Added to DOAB on : 2018-06-22 11:47:05
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Malnutrition in people with liver disease is a challenging issue due to its multifactorial nature, which includes hypermetabolism, increased energy needs, malabsorption, and anorexia. Despite advances in both assessment and management, correct nutritional support is still an often-unanswered need in the care of these patients to avoid poor outcomes. One of the central issues remains how to improve muscolar mass of sarcopenic chronically malnourished individuals with end stage liver diseases and cirrhosis, as only a correct nutritional assessment and subsequent nutritional handling may enhance quality of life and disease outcome. Nutritional management is mandatory in certain inherited metabolic/genetic defects: in these patients specific dietary restrictions/supplementations represent a challenge to guarantee optimal growth and liver health.A nutraceutical approach dealing with hepatoprotective effects of specific nutrients, has been proposed for several chronic liver disease, mainly in obesity related liver disease and alcoholic liver disease. Finally, other challenges are represented by tailored nutritional intervention in improving gut–liver axis dysfunction also in parenteral nutrition/intestinal failure associated liver disease, inflammatory bowel disease, and celiac disease.The purpose of this Special Issue, “Nutrition and Liver Disease”, is to provide novel information and perspectives in the field of nutrition in liver disease and its management.

Algorithms for Scheduling Problems

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ISBN: 9783038971191 9783038971207 Year: Pages: XIV, 194 Language: Englisch
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Computer Science --- Mathematics
Added to DOAB on : 2018-08-24 16:46:30
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This edited book presents new results in the area of algorithm development for different types of scheduling problems. In eleven chapters, algorithms for single machine problems, flow-shop and job-shop scheduling problems (including their hybrid (flexible) variants), the resource-constrained project scheduling problem, scheduling problems in complex manufacturing systems and supply chains, and workflow scheduling problems are given. The chapters address such subjects as insertion heuristics for energy-efficient scheduling, the re-scheduling of train traffic in real time, control algorithms for short-term scheduling in manufacturing systems, bi-objective optimization of tortilla production, scheduling problems with uncertain (interval) processing times, workflow scheduling for digital signal processor (DSP) clusters, and many more.

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