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Analysis of microparticles is an important tool in medicine, biology and chemistry. In order to address future application areas, new systems will be produced by printing technology. In this work new microfluidic particle detection systems which employ planar optics are developed and analyzed. Because the characteristic of these new systems differs greatly from established particle detection systems the signals and statistics are analyzed in depth.

Mikrofluidik, Mikropartikel, Partikeldetektion, Signalanalyse, Fehlerstatistik, Microfluidics, Microparticles, Particle detection, signal analysis, error statistics

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The most commonly used measurement technique for electrophysiology is the patch clamp technique. While this measurement technique allows the precise investigation of the communication taking place through ion channels, it has some undesirable drawbacks such as the local destruction of the plasma membrane, a low success rate and an elaborate experimental procedure. To avoid these drawbacks, in this work a new non-invasive microfluidic platform for electrophysiological research (NIMEP) was developed with regard to the activity of ion channels. This novel approach is based on the non-invasive measurement of the total current through the cell membrane and provides a possibility for an automated investigation of the individual cells. In addition, the investigated cell can be used for other applications, since the cell remains in an intact state before and after the test.

Mikrofluidik, Nicht-invasiv, Ionenkanal, Patch-Clamp-Technik, Elektrophysiologie, Microfluidics, Non-invasive, Ion channel, Patch clamp technique, Electrophysiology