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Structural Bridge Engineering

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ISBN: 9789535126881 9789535126898 Year: Pages: 198 DOI: 10.5772/61683 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 07:51:49

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There are many books on preliminary studies and research in bridge design as well as basic knowledge on bridge engineering, but most books supply the needs of practicing engineers who may have problems in estimating, designing or constructing suspension bridges. Therefore, this book is intended to serve as a source of information for problems related to bridge engineering including sustainable bridge development, traditional approaches and recent advances in highway bridge traffic loading, aesthetic analysis issues in designing a new bridge, applications of various methods for the dissipation of seismic energy for bridges, new technologies of bridge design as well as structural identification of bridges using non-destructive experimental measurement tests.

Wood in Civil Engineering

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ISBN: 9789535129851 9789535129868 9789535141075 Year: Pages: 250 DOI: 10.5772/63178 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 07:51:49

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Wood is a natural building material: if used in building elements, it can play structural, functional and aesthetic roles at the same time. The use of wood in buildings, which goes back to the oldest of times, is now experiencing a period of strong expansion in virtue of the sustainable dimension of wood buildings from the environmental, economic and social standpoints. However, its use as an engineering material calls for constant development of theoretical and experimental research to respond properly to the issues involved in this. In the single chapters written by experts in different fields, the book aims to contribute to knowledge in the application of wood in the building industry.

Protein-Protein Interaction Assays

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ISBN: 9781789233902 9781789233919 Year: Pages: 90 DOI: 10.5772/intechopen.71741 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:51

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The chapters in this book are written by a team of well-reputed international researchers. The objective is to provide advanced and updated information related to protein-protein interactions. I hope the methods, resources and approaches described here will enhance the available knowledge of the reader significantly.

Peripheral Membrane Proteins

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ISBN: 9781789235128 9781789235135 Year: Pages: 132 DOI: 10.5772/intechopen.71809 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:51

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The peripheral membrane proteins transduce the extracellular signaling into the cells. The peripheral membrane proteins include the G protein-coupled receptors, receptor tyrosine kinases, channels and transporters. The signals, which are transduced via the peripheral membrane proteins, activate several pathways including G protein signaling, MAPK signaling, TNF signaling, TGF? signaling, Wnt signaling and Hedgehog signaling. The peripheral membrane proteins transduce the signaling from the extracellular ligands into the cells. This book intends to provide a comprehensive overview of the features and signaling of peripheral membrane proteins, which includes the molecular structure and interaction. The insights into membrane proteins associated with diseases and therapeutics and the effects of drugs and chemicals are also discussed in this book.

Ubiquitination Governing DNA Repair - Implications in Health and Disease

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ISBN: 9781789235845 9781789235852 Year: Pages: 220 DOI: 10.5772/66565 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:51

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DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

New Trends in Structural Engineering

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ISBN: 9781789845068 9781789845075 Year: Pages: 138 DOI: 10.5772/intechopen.73625 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 07:51:52

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The book presents a collection of articles on novel approaches to problems of current interest in structural engineering by academicians, researchers, and practicing structural engineers from all over the world. The book is divided into five chapters and encompasses multidisciplinary areas within structural engineering, such as structural dynamics and impact loading, structural mechanics, finite element modeling, structural vibration control, and the application of advanced composite materials. New Trends in Structural Engineering is a useful reference material for the structural engineering fraternity, including undergraduate and postgraduate students, academicians, researchers, and practicing engineers.

Elasticity of Materials - Basic Principles and Design of Structures

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ISBN: 9781789849271 9781789849288 Year: Pages: 106 DOI: 10.5772/intechopen.71471 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 07:51:52

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In the science of physics, elasticity is the ability of a deformable body (e.g., steel, aluminum, rubber, wood, crystals, etc.) to resist a distorting effect and to return to its original size and shape when that influence or force is removed. Solid bodies will deform when satisfying forces are applied to them. Elasticity solution of materials will be grouped in forms of linear and nonlinear elasticity formulations. The main subject of this book is engineering elasticity and consists of five chapters in two main sections. These two main sections are ""General Theorems in Elasticity"" and ""Engineering Applications in Theory of Elasticity."" The first chapter of the first section belongs to the editor and is entitled ""Analytical and Numerical Approaches in Engineering Elasticity."" The second chapter in the first section is entitled ""A General Overview of Stress-Strain Analysis for the Elasticity Equations"" by P. Kumar, M. Mahanty, and A. Chattopadhyay. The first chapter of the second section is entitled ""FEA and Experimental Determination of Applied Elasticity Problems for Fabricating Aspheric Surfaces"" by Dr. D.N. Nguyen. The second chapter is entitled ""Concept of Phase Transition Based on Elastic Systematics"" by Dr. P.S. Nnamchi and Dr. C.S. Obayi. The third chapter is entitled ""Repair Inspection Technique Based on Elastic-Wave Tomography Applied for Deteriorated Concrete Structures"" by Dr. K. Hashimoto, Dr. T. Shiotani, Dr. T. Nishida, and Dr. N. Okude. Finally, this book includes the basic principles of elasticity and related engineering applications about theory and design.

Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease

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ISBN: 9781838804909 9781838804916 9781838807177 Year: Pages: 226 DOI: 10.5772/intechopen.78430 Language: English
Publisher: IntechOpen
Subject: Microbiology
Added to DOAB on : 2019-10-03 07:51:53

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The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Proceedings of the 2nd Czech-China Scientific Conference 2016

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ISBN: 9789535128571 9789535128588 Year: Pages: 434 DOI: 10.5772/66773 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 09:47:10

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This book comprises the proceedings of the 2nd Czech-China Scientific Conference 2016 which was held on 7th June 2016 in Ostrava, Czech Republic. The objective of the conference was to present the latest achievements in the fields of advanced science and technology that stem from research activities of V

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