Search results: Found 8

Listing 1 - 8 of 8
Sort by
Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193912 Year: Pages: 178 DOI: 10.3389/978-2-88919-391-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2015-12-03 13:02:24
License:

Loading...
Export citation

Choose an application

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines.

Mental Practice - Clinical and Experimental Research in Imagery and Action Observation

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198399 Year: Pages: 208 DOI: 10.3389/978-2-88919-839-9 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

There is now strong evidence demonstrating that the brain simulates action and other functions. Such action simulation can be evoked through conscious mental rehearsal of movement or imagery, but also through passive action observation watching movements in others. Furthermore, there is evidence to suggest that mental rehearsal of movement, or mental practice, can produce improvements normally attributed to practising actual movements. It is currently assumed that such improvements are due to neural activation associated with action simulation. However the neuroscience of mental practice efficacy is still poorly understood. The aim of this research topic is to clarify the underlying mechanisms of mental practice, bringing evidence from cognitive neuroscience, experimental neuropsychology, sport and movement science, and clinical neurology. It also attempts to address confusion regarding the concepts of imagery and observation, which has hampered the progression of mental practice research both scientifically and applied. As well as reviews, theoretical, and position articles, this research topic includes original neuroimaging, experimental, and patient research addressing, among others, the following issues. Neuroimaging studies provide strong evidence for action simulation, but the link to behavioural change and functional outcome is weak. What is the evidence that mental practice efficacy is driven by neuroplasticity processes evoked by action simulation? This research topic includes contributions on neural correlates and behaviour with regards to imagery and action observation. Much of the mental practice efficacy evidence comes from longstanding research within sport science. However, what does mental practice entail in these contexts, and to what extent is it compatible with the cognitive neuroscience perspective of action simulation? This research topic will include contributions that consider both evidence and concepts with regards to imagery and action observation, in an attempt to build an interdisciplinary consensus on the nature and application of mental practice. Mental practice is perceived as a promising motor rehabilitation technique, but critically there is lack of clarity or consensus on what mental practice treatment should entail. It is also not clear what are the most appropriate outcomes to measure imagery ability and cognitive or behavioural change following mental practice. A further important issue that needs consideration as part of this research topic is dosage, as it is currently unclear how much mental practice is appropriate and whether this depends on patient variables such as age, cognitive functioning, motor function, or pathophysiology.

Interoception, Contemplative Practice, and Health

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450947 Year: Pages: 316 DOI: 10.3389/978-2-88945-094-7 Language: English
Publisher: Frontiers Media SA
Subject: Psychology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
License:

Loading...
Export citation

Choose an application

Abstract

There is an emergent movement of scientists and scholars working on somatic awareness, interoception and embodiment. This work cuts across studies of neurophysiology, somatic anthropology, contemplative practice, and mind-body medicine. Key questions include: How is body awareness cultivated? What role does interoception play for emotion and cognition in healthy adults and children as well as in different psychopathologies? What are the neurophysiological effects of this cultivation in practices such as Yoga, mindfulness meditation, Tai Chi and other embodied contemplative practices? What categories from other traditions might be useful as we explore embodiment? Does the cultivation of body awareness within contemplative practice offer a tool for coping with suffering from conditions, such as pain, addiction, and dysregulated emotion? This emergent field of research into somatic awareness and associated interoceptive processes, however, faces many obstacles. The principle obstacle lies in our 400-year Cartesian tradition that views sensory perception as epiphenomenal to cognition. The segregation of perception and cognition has enabled a broad program of cognitive science research, but may have also prevented researchers from developing paradigms for understanding how interoceptive awareness of sensations from inside the body influences cognition. The cognitive representation of interoceptive signals may play an active role in facilitating therapeutic transformation, e.g. by altering context in which cognitive appraisals of well-being occur. This topic has ramifications into disparate research fields: What is the role of interoceptive awareness in conscious presence? How do we distinguish between adaptive and maladaptive somatic awareness? How do we best measure somatic awareness? What are the consequences of dysregulated somatic/interoceptive awareness on cognition, emotion, and behavior? The complexity of these questions calls for the creative integration of perspectives and findings from related but often disparate research areas including clinical research, neuroscience, cognitive psychology, anthropology, religious/contemplative studies and philosophy.

Psychological perspectives on expertise

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195206 Year: Pages: 240 DOI: 10.3389/978-2-88919-520-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2015-12-10 11:59:06
License:

Loading...
Export citation

Choose an application

Abstract

Experts are persons who are very knowledgeable about or skillful in a particular area. The aim of this Research Topic is to advance knowledge in the understanding of the phenomenon of expertise by putting together different lines of research that directly or indirectly study expertise. Herbert Simon’s expertise studies initiated two lines of research. One is interested in elucidating the cognitive processes underlying expertise, and the other investigates how expertise develops. These lines of research started with studies comparing experts and novices in chess, and then they extended to numerous areas of expertise such as music, medical diagnosis, sports, arts and sciences. In the field of judgment and decision making researchers investigate the quality of judgments and decisions of experts in different professions (e.g., clinical psychologists, medical practitioners, judges, meteorologists, stock brokers). Those lines of research explicitly investigate the topic of expertise, but there are other research areas that make a substantial contribution to understanding expertise. Scholars in language acquisition and in face perception, for example, investigate cognitive processes and development of expertise in areas in which almost everyone becomes an expert. Furthermore, skill acquisition research informs in detail about short term cognitive changes that may be important to understand how expertise develops. We are interested in original research that advances knowledge in the understanding of decision making, cognitive processes and development of expertise in sports, intellectual games, arts, scientific disciplines and professions, as well as expertise in cognitive abilities such as perception, memory, attention, language and imagery. We are also interested in theoretical articles in any of these areas, articles that describe computational or mathematical models of expertise, and articles offering a framework that would guide expertise research. Articles that offer integrative approaches of some of the areas described above are strongly encouraged. The goal of this Research Topic is to produce a hallmark piece of work in the field of expertise, which complements and does not overlap with the “Neural implementations of expertise” Research Topic in Frontiers in Human Neuroscience.

Manual Asymmetries, Handedness and Motor Performance

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198634 Year: Pages: 147 DOI: 10.3389/978-2-88919-863-4 Language: English
Publisher: Frontiers Media SA
Subject: Psychology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

The performance of most tasks with one hand, typically the right, is a uniquely human characteristic. Not only do people prefer to use one hand rather than the other, but also they usually perform tasks faster and more accurately with this hand. The study of manual asymmetries and what such performance differences between the two hands reveal about brain organization and motor function has been a topic of considerable research over the last several decades. The aim of this Research Topic is to review and further explore the origins of manual asymmetries and their relationship to handedness, unimanual and bimanual motor performance, and brain function. The articles included here involve original research conducted in humans or non-human models species, as well as theoretical perspectives, review articles, and meta-analyses.

What can neuroscience learn from contemplative practices?

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199716 Year: Pages: 166 DOI: 10.3389/978-2-88919-971-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

A recent wave of brain research has advanced our understanding of the neural mechanisms of conscious states, contents and functions. A host of questions remain to be explored, as shown by lively debates between models of higher vs. lower-order aspects of consciousness, as well as global vs. local models. (Baars 2007; Block, 2009; Dennett and Cohen, 2011; Lau and Rosenthal, 2011). Over some twenty-five centuries the contemplative traditions have also developed explicit descriptions and taxonomies of the mind, to interpret experiences that are often reported in contemplative practices (Radhakrishnan & Moore, 1967; Rinbochay & Naper, 1981). These traditional descriptions sometimes converge on current scientific debates, such as the question of conceptual vs. non-conceptual consciousness; reflexivity or “self-knowing” associated with consciousness; the sense of self and consciousness; and aspects of consciousness that are said to continue during sleep. These real or claimed aspects of consciousness have not been fully integrated into scientific models so far. This Research Topic in Consciousness Research aims to provide a forum for theoretical proposals, new empirical findings, integrative literature reviews, and methodological improvements inspired by meditation-based models. We include a broad array of topics, including but not limited to: replicable findings from a variety of systematic mental practices; changes in brain functioning and organization that can be attributed to such practices; their effects on adaptation and neural plasticity; measurable effects on perception, cognition, affect and self-referential processes. We include contributions that address the question of causal attribution. Many published studies are correlational in nature, because of the inherent difficulty of conducting longitudinal experiments based on a major lifestyle decision, such as the decision to commit to a mental practice over a period of years. We also feature clinical and case studies, integrative syntheses and significant opinion articles.

Brain-Mind-Body Practice and Health

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453665 Year: Pages: 160 DOI: 10.3389/978-2-88945-366-5 Language: English
Publisher: Frontiers Media SA
Subject: Psychology --- Science (General)
Added to DOAB on : 2018-02-27 16:16:45
License:

Loading...
Export citation

Choose an application

Abstract

It is acknowledged that practice could induce rapid change or reorganization of the brain’s cellular or neural networks as well as behaviors. Notably, practice relevant to mental or physical approach attracted great attention in this decade. It highlights profound significance both for human evolvement and individual development. Specifically, acquiring fine motor skills is a crucial premise for human being to evolve to modern human by using tools in one side. In the other side, numerous evidences indicated that motor learning involved in limb and trunks promotes the development of individual brain in anatomy and functions. Hence, motor learning is also tightly associated with developmental plasticity. These studies on brain-mind-body practice illuminate a promising way in promoting human brain health. This editorial covers wide range of brain-mind-body practice forms to summarize recent new findings and development from behavioral, physiological, neurobiological and psychological science approaches. In this research topic, we addressed recent findings from theoretical as well as experimental perspective including contributions under the following three headings: 1) intervention studies to investigate the positive effect of brain-mind-body practice on cognition and relevant brain mechanism. The intervention pattern consisted of short-term practice ranging from few hours to several weeks; 2) cross-sectional studies using expert-novice paradigm to explore the behavioral and neural system change induced by extensive brain-mind-body practice; 3) the mediators influence the relationship between practice and health outcomes and 4) new viewpoints on brain-mind-body practice from theoretical perspectives. Here we briefly highlight these articles aiming to provide a deep understanding for the association between practice, plasticity and health for readers. Additionally, it offers new insights for developing possible practice interventions for clinical treatment of neurological dysfunction or disorders.

Inter-healthcare Professions Collaboration: Educational and Practical Aspects and New Developments

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199976 Year: Pages: 28 DOI: 10.3389/978-2-88919-997-6 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Settings, such as patient-centered medical homes, can serve as ideal places to promote interprofessional collaboration among healthcare providers (Fjortoft et al., 2016). Furthermore, work together by teams of interprofessional healthcare students (Van Winkle, 2015) and even practitioners (Stringer et al., 2013) can help to foster interdisciplinary collaboration. This result occurs, in part, by mitigating negative biases toward other healthcare professions (Stringer et al., 2013; Van Winkle 2016). Such changes undoubtedly require increased empathy for other professions and patients themselves (Tamayo et al., 2016). Nevertheless, there is still much work to be done to foster efforts to promote interprofessional collaboration (Wang and Zorek, 2016). This work should begin with undergraduate education and continue throughout the careers of all healthcare professionals.

Listing 1 - 8 of 8
Sort by
Narrow your search

Publisher

Frontiers Media SA (8)


License

CC by (8)


Language

english (8)


Year
From To Submit

2018 (1)

2017 (1)

2016 (4)

2015 (2)