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Aptamer-Nanoparticle Bioconjugates for Drug Delivery (Book chapter)

Book title: The Delivery of Nanoparticles

Authors: ---
ISBN: 9789535106159 Year: DOI: 10.5772/35188 Language: English
Publisher: IntechOpen Grant: FP7 Ideas: European Research Council - 209842
Subject: Science (General)
Added to DOAB on : 2019-01-17 11:47:59
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Abstract

Drug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found applicability in the development of novel drug delivery systems by easily overcoming toxicity problem. However, specificity of delivery has remained as a challenge. Developments in the methods of reaching to targeted tissue have lead to new and improved drug delivery platforms. Recently, active targeting has been incorporated by cell specific ligands such as antibodies, lectins, growth factor receptors. More recently, aptamers gained popularity in construction of novel actively targeted drug delivery systems (Ozalp et al., 2011). Considerable proportions of aptamer-based delivery systems have been incorporated to a variety of nanomaterials in order to improve their specific targeting properties (Chen et al., 2011; Zhou et al., 2011).

Advanced Technology for Delivering Therapeutics

Authors: ---
ISBN: 9789535131212 9789535131229 Year: Pages: 184 DOI: 10.5772/62564 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:50

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The goal of any novel drug delivery system is to provide therapeutic benefits to the patients by increasing duration of drug action, reducing dosing frequency, and controlling drug release rate at the target site, thereby reducing unwanted side effects. Advanced Technology for Delivering Therapeutics is a reference book that covers recent developments in the field of drug delivery science and technology. The purpose of this book is to bring together descriptions of some selective technologies including new and promising nanotechnology currently being investigated for drug delivery applications. This book is a useful source of information for graduate and post-graduate students of pharmacy and biomedical science; pharmaceutical & other researchers involved in designing newer drug delivery systems both in academia and industry.

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