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Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

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ISBN: 9783038427971 9783038427988 Year: Pages: VIII, 302 DOI: 10.3390/books978-3-03842-798-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-04-06 13:44:18
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Abstract

Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population.This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.

Molecular Science for Drug Development and Biomedicine

ISBN: 9783906980836 9783906980843 Year: Pages: 356
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 06:15:53
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With the avalanche of biological sequences generated in the postgenomic age, molecular science is facing an unprecedented challenge, i.e., how to timely utilize the huge amount of data to benefit human beings. Stimulated by such a challenge, a rapid development has taken place in molecular science, particularly in the areas associated with drug development and biomedicine, both experimental and theoretical. The current thematic issue was launched with the focus on the topic of “Molecular Science for Drug Development and Biomedicine”, in hopes to further stimulate more useful techniques and findings from various approaches of molecular science for drug development and biomedicine.

Organs-on-chips

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ISBN: 9783039289172 / 9783039289189 Year: Pages: 262 DOI: 10.3390/books978-3-03928-918-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.

Keywords

microfluidics --- vascularization --- organ-on-a-chip --- vascularized tumor model --- tissue engineering --- microfluidic device --- cell culture --- organ-on-chips --- lung epithelial cell --- surfactant protein --- angiogenesis --- shear stress --- biomechanics --- vessel branching --- beating force --- bio-mechanical property --- cardiac 3D tissue --- human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) --- tissue engineering --- vacuum chuck --- barrier permeability --- epithelial–endothelial interface --- paracellular/transcellular transport --- organ-on-chip --- MEMS --- silicon --- PDMS --- membranes --- cell --- strain --- stress --- lattice light-sheet microscopy --- 3D cell culture system --- functional neuron imaging --- 3D cell culture --- neuronal cells --- SH-SY5Y cells --- image-based screening --- nanogrooves --- neuronal cell networks --- neuronal guidance --- drug metabolism --- biomimetic oxidation --- microfluidics --- organ-on-a-chip --- liver-on-a-chip --- liver-on-a-chip --- drug hepatotoxicity --- drug metabolism --- organoid --- 3D cell culture --- spheroid array --- high-throughput screening --- drug efficacy --- organ-on-a-chip (OOC) --- microfluidic device --- mechanical cue --- shear flow --- compression --- stretch --- strain --- syringe pump --- integrated pump --- passive delivery --- organs-on-chips --- microfluidics --- drug absorption --- fluoroelastomer --- ischemia/reperfusion injury --- thrombolysis --- organ-on-a-chip --- endothelial cell activation --- microfluidics --- microfabrication --- organ-on-a-chip --- trans-epithelial electrical resistance --- multi-culture --- n/a

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