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Soft Tissue and Bone Sarcoma

ISBN: 9783906980461 9783906980584 Year: Pages: 156 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:17:42
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Soft tissue and bone sarcomas disproportionately affect children, adolescents, and young adults. Although considered a rare disease, sarcomas continue to have a devastating effect on these patients and their loved ones, and their impact on our society far exceed their relatively low prevalence. Because of its rarity and heterogeneity, clinical decision making on management of sarcomas are often individualized and without a consensus treatment strategy. Furthermore, research to improve clinical outcomes are particularly challenging as sizeable studies are hard to produce. By improving our knowledge about the molecular biology of sarcomas, we hope to identify new treatment strategies and targets for further drug development. [...]

Insights and Advancements in Microfluidics

Authors: --- ---
ISBN: 9783038425168 9783038425175 Year: Pages: VI, 287 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2017-10-02 11:51:06
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Microfluidics has developed rapidly over the past three decades. Relentless diagnostic, medical and chemical applications have been demonstrated in various applications, plateforms and tools. Have microfluidics realized its full potential? Or is it only a leveraging academic tool? In this Special Issue, we focus on both insights and advancements in microfluidics. We invite emerging investigators and pioneers to contribute commentaries, perspectives and insightful reviews on related topics. The various insights from esteemed colleagues will be collated. We will also discuss technological breakthrough of original works in both short communications and full papers. The main idea is to stimulate the community and to provide an unique collection of insightful papers. We will also cover various topics ranging from 3D printing, paper-based microfludics to conventional polymer-based microfluidics which contributes to the technological advancements.

Sustainable Territorial Management

Authors: ---
ISBN: 9783038972129 9783038972136 Year: Pages: 224 DOI: 10.3390/books978-3-03897-213-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences
Added to DOAB on : 2018-09-21 09:54:53
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Human development has made remarkable social and economic progress possible for most of us but has also entailed a range of serious impacts on natural resources, local communities and the economy at multiple scales. Thus, achieving sustainable territorial management that combines healthy and prosperous societies with the long-term maintenance of biodiversity and productive ecosystem services remains the biggest challenge of our modern world. This Special Issue seeks to collect a coherent set of studies on techniques and experiences (case studies) aimed at increasing the environmental, social, economic &/or institutional sustainability of landscapes and seascapes from a range of geographic and socioeconomic contexts. Ten case studies representing urban areas, rural areas (chiefly protected areas) and coastal areas from four countries in Europe and Asia by internationally renowned authors are shown.

Selected Papers from SDEWES 2017: The 12th Conference on Sustainable Development of Energy, Water and Environment Systems

Authors: --- --- --- --- et al.
ISBN: 9783038973966 / 9783038973973 Year: Pages: 346 DOI: 10.3390/books978-3-03897-397-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Mechanical Engineering
Added to DOAB on : 2019-02-04 12:23:05
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EU energy policy is more and more promoting a resilient, efficient and sustainable energy system. Several agreements have been signed in the last few months that set ambitious goals in terms of energy efficiency and emission reductions and to reduce the energy consumption in buildings. These actions are expected to fulfill the goals negotiated at the Paris Agreement in 2015. The successful development of this ambitious energy policy needs to be supported by scientific knowledge: a huge effort must be made in order to develop more efficient energy conversion technologies based both on renewables and fossil fuels. Similarly, researchers are also expected to work on the integration of conventional and novel systems, also taking into account the needs for the management of the novel energy systems in terms of energy storage and devices management. Therefore, a multi-disciplinary approach is required in order to achieve these goals. To ensure that the scientists belonging to the different disciplines are aware of the scientific progress in the other research areas, specific Conferences are periodically organized. One of the most popular conferences in this area is the Sustainable Development of Energy, Water and Environment Systems (SDEWES) Series Conference. The 12th Sustainable Development of Energy, Water and Environment Systems Conference was recently held in Dubrovnik, Croatia. The present Special Issue of Energies, specifically dedicated to the 12th SDEWES Conference, is focused on five main fields: energy policy and energy efficiency in smart energy systems, polygeneration and district heating, advanced combustion techniques and fuels, biomass and building efficiency.

Reinventing Healthy Communities: Implications for Individual and Societal Well-Being

ISBN: 9783038422624 9783038422631 Year: Pages: X, 220 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Sociology
Added to DOAB on : 2016-10-14 08:33:14
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Contemporary views of “livable communities” maintain that density and diversity are good for cities. Healthy communities are more pedestrian-friendly and less automobile-centric. Mixed use zoning keeps a flow of people through parks, streets, neighborhoods, and districts, which is good for business, safety, and tourism. Dwellings are human scale and locally-sourced food is more sustainable for the environment and healthier for individuals. But how should social institutions collaborate with those of the economic and political sectors to maximize community well-being? The United Way partnership model and the growing concern for triple-bottom-line outcomes involving financial, social, and environmental considerations offer a broad perspective on healthy communities.This special collection, therefore, employs a wide lens to examine multiple factors that characterize healthy communities including inclusiveness, equity, human rights, and mutual assistance. Researchers from various fields including psychiatry, public health, sociology, political science, community planning, economics, kinesiology, and social work present their findings on critical issues impacting the health of communities.

Geothermal Energy: Delivering on the Global Potential

ISBN: 9783038421337 9783038421344 Year: Pages: 430 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-20 14:48:30
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After decades of being largely the preserve of countries in volcanic regions, the use of geothermal energy—for both heat and power applications—is now expanding worldwide. This reflects its excellent low-carbon credentials and its ability to offer baseload and dispatchable output - rare amongst the mainstream renewables. Yet uptake of geothermal still lags behind that of solar and wind, principally because of (i) uncertainties over resource availability in poorly-explored reservoirs and (ii) the concentration of full-lifetime costs into early-stage capital expenditure (capex). Recent advances in reservoir characterization techniques are beginning to narrow the bounds of exploration uncertainty, both by improving estimates of reservoir geometry and properties, and by providing pre-drilling estimates of temperature at depth. Advances in drilling technologies and management have potential to significantly lower initial capex, while operating expenditure is being further reduced by more effective reservoir management — supported by robust mathematical models — and increasingly efficient energy conversion systems (flash, binary and combined-heat-and-power). Advances in characterization and modelling are also improving management of shallow low-enthalpy resources that can only be exploited using heat-pump technology. Taken together with increased public appreciation of the benefits of geothermal, the technology is finally ready to take its place as a mainstream renewable technology, This book draws together some of the latest developments in concepts and technology that are enabling the growing realisation of the global potential of geothermal energy in all its manifestations.After decades of being largely the preserve of countries in volcanic regions, the use of geothermal energy—for both heat and power applications—is now expanding worldwide. This reflects its excellent low-carbon credentials and its ability to offer baseload and dispatchable output - rare amongst the mainstream renewables. Yet uptake of geothermal still lags behind that of solar and wind, principally because of (i) uncertainties over resource availability in poorly-explored reservoirs and (ii) the concentration of full-lifetime costs into early-stage capital expenditure (capex). Recent advances in reservoir characterization techniques are beginning to narrow the bounds of exploration uncertainty, both by improving estimates of reservoir geometry and properties, and by providing pre-drilling estimates of temperature at depth. Advances in drilling technologies and management have potential to significantly lower initial capex, while operating expenditure is being further reduced by more effective reservoir management — supported by robust mathematical models — and increasingly efficient energy conversion systems (flash, binary and combined-heat-and-power). Advances in characterization and modelling are also improving management of shallow low-enthalpy resources that can only be exploited using heat-pump technology. Taken together with increased public appreciation of the benefits of geothermal, the technology is finally ready to take its place as a mainstream renewable technology.

Adolescent Pregnancy: Past, Present and Future Trends and Issues

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ISBN: 9783038422945 9783038422952 Year: Pages: X, 172 DOI: 10.3390/books978-3-03842-295-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences
Added to DOAB on : 2016-12-27 09:48:30
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This collection provides a forum for leading scholars to examine theoretical insights and empirical findings associated with the recent decline in adolescent pregnancy and childbearing internationally, with special attention given to the United States. This recent shift in the incidence of adolescent fertility is notable in its consistency and magnitude; at the same time, however, continuing historic disparities require focused attention on the contemporary meaning of early childbearing in the U.S. as well as across the globe.The widely interdisciplinary contributions focus on demographic trends in adolescent fertility; successful intervention approaches and major “lessons learned” regarding primary pregnancy prevention; identification of key theoretical issues associated with these trends, with particular focus on the existence and meaning of disparities and their implications for youth development and wellbeing.

Brain Asymmetry of Structure And/Or Function

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ISBN: 9783038425502 9783038425519 Year: Pages: VIII, 148 DOI: 10.3390/books978-3-03842-551-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-12-28 13:57:29
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This edited book brings together research reports on the asymmetry of brain function in various species, including humans, dogs, birds, lizards and bees. As shown in a wide range of species, and, as we now know, not solely in humans, the left and right sides of the brain process information in different ways and control different responses or patterns of behaviour. Since this discovery, many new methods have become available to reveal the processes involved in the development, function and evolution of this important attribute of the brain. Chapters consider the evidence for asymmetry of sensory receptors, left–right differences in information processing and asymmetrical control of behaviour. The latter includes lateralization of bird song and use of the magnetic compass in navigation. Other chapters report studies on handedness, hemispheric asymmetries in emotional processing and perception of symmetry in humans. The importance of the degree, or strength, of asymmetry is discussed and the conclusion is that asymmetry of the brain enhances its efficiency. Other chapters provide evidence that early experience influences the development of asymmetry. All of the contributors have strong backgrounds in research and they discuss up-to-date discoveries on lateralized brain and behaviour.

Hybrid Modelling and Multi- Parametric Control of Bioprocesses

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ISBN: 9783038427452 9783038427469 Year: Pages: 148 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-02-16 08:40:41
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The goal of bioprocessing is to optimize process variables, such as product quantity and quality, in a reproducible, scalable, and transferable manner. However, bioprocesses are highly complex. A large number of process parameters and raw material attributes exist, which are highly interactive, and may vary from batch to batch. Those interactions need to be understood, and the source of variance must be identified and controlled.While purely data-driven correlations, such as chemometric models of spectroscopic data, may be employed for the understanding how process parameters are related to process variables, they can hardly be deployed outside of the calibration space. Currently, mechanistic models, models based on mechanistic links and first principles, are in the focus of development. They are perceived to allow transferability and scalability, because mechanistics can be extrapolated. Moreover, the models deliver a large range of hardly-measureable states and physiological parameters.The current Special Issue wants to display current solutions and case studies of development and deployment of hybrid models and multi-parametric control of bioprocesses. It includes: •Models for Bioprocess Monitoring•Model for Bioreactor Design and Scale Up•Hybrid model solutions, combinations of data driven and mechanistic models.•Model to unravel mechanistic physiological regulations•Implementation of hybrid models in the real-time context•Data science driven model for process validation and product life cycle management

MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers

Authors: ---
ISBN: 9783038972525 9783038972532 Year: Pages: 272 DOI: 10.3390/books978-3-03897-253-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics --- Oncology
Added to DOAB on : 2018-10-16 10:23:45
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MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes—which are derived from multiple cell types—including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers.

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