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Information Theory in Neuroscience

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ISBN: 9783038976646 Year: Pages: 280 DOI: 10.3390/books978-3-03897-665-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Mathematics --- Science (General)
Added to DOAB on : 2019-03-21 15:50:41
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As the ultimate information processing device, the brain naturally lends itself to being studied with information theory. The application of information theory to neuroscience has spurred the development of principled theories of brain function, and has led to advances in the study of consciousness, as well as to the development of analytical techniques to crack the neural code—that is, to unveil the language used by neurons to encode and process information. In particular, advances in experimental techniques enabling the precise recording and manipulation of neural activity on a large scale now enable for the first time the precise formulation and the quantitative testing of hypotheses about how the brain encodes and transmits the information used for specific functions across areas. This Special Issue presents twelve original contributions on novel approaches in neuroscience using information theory, and on the development of new information theoretic results inspired by problems in neuroscience.

Neuroproteomics

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ISBN: 9783039281060 9783039281077 Year: Pages: 318 DOI: 10.3390/books978-3-03928-107-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2020-04-07 23:07:08
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The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes.

Keywords

proteomics --- basal ganglia --- synapses --- synapse specificity --- neuronal circuits --- axons --- dendrites --- neurodegeneration --- synapse --- postsynaptic --- proteome --- mass spectrometry --- protein interaction networks --- connectome --- neurodegeneration --- Alzheimer’s disease --- cerebrospinal fluid --- plasma --- serum --- proteomics --- biomarkers --- LC-MS/MS --- cocaine --- addiction --- cytokine --- neuroimmune --- ventral tegmental area --- peptidylglycine ?-amidating monooxygenase --- cilia --- mating --- signal peptide --- prohormone convertase --- carboxypeptidase --- matrix metalloproteinase --- subtilisin --- pherophorin --- morphine --- opioid receptors --- conformational antibody --- analgesia --- GPCR signaling --- phosphorylation --- AMPA receptor complex --- transmembrane AMPA receptor regulatory protein --- synaptic plasticity --- adolescence --- corticosterone --- proteomics --- yohimbine --- progressive ratio --- reinstatement --- ethanol --- nicotinic receptor --- CaMKII --- PKA --- quantitative phosphoproteomics --- mouse --- phosphorylation --- nicotine --- proteomics --- proteome --- mass spectrometry --- Alzheimer’s disease --- protein aggregation --- laser capture microdissection --- splicing --- U1 snRNP --- synapse --- synaptic cleft --- trans-synaptic adhesion --- proximity labeling --- SynCAM --- Cadm --- Receptor-type tyrosine-protein phosphatase zeta --- R-PTP-zeta --- Ptprz1 --- neuroproteome --- drug abuse --- neuropeptidomics --- phosphorylation --- interactome --- cell type --- neuroscience --- proteomics --- mass spectrometry --- neuron --- proximity labeling --- affinity chromatography --- neuroproteomics --- biotinylation --- amphetamine --- spinophilin --- protein phosphatase-1 --- dopamine --- striatum --- mass spectroscopy --- bioinformatics --- FGF14 --- voltage gated channels --- schizophrenia --- autism --- Alzheimer’s Disease --- sex-specific differences --- synaptic plasticity --- cognitive impairment --- excitatory/inhibitory tone --- n/a --- postsynaptic density --- PSD --- parallel reaction monitoring --- PRM --- targeted proteomics --- data-independent acquisition --- DIA --- quantitative mass spectrometry --- n/a

Neural Microelectrodes: Design and Applications

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ISBN: 9783039213191 9783039213207 Year: Pages: 378 DOI: 10.3390/books978-3-03921-320-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Neural electrodes enable the recording and stimulation of bioelectrical activity in the nervous system. This technology provides neuroscientists with the means to probe the functionality of neural circuitry in both health and disease. In addition, neural electrodes can deliver therapeutic stimulation for the relief of debilitating symptoms associated with neurological disorders such as Parkinson’s disease and may serve as the basis for the restoration of sensory perception through peripheral nerve and brain regions after disease or injury. Lastly, microscale neural electrodes recording signals associated with volitional movement in paralyzed individuals can be decoded for controlling external devices and prosthetic limbs or driving the stimulation of paralyzed muscles for functional movements. In spite of the promise of neural electrodes for a range of applications, chronic performance remains a goal for long-term basic science studies, as well as clinical applications. New perspectives and opportunities from fields including tissue biomechanics, materials science, and biological mechanisms of inflammation and neurodegeneration are critical to advances in neural electrode technology. This Special Issue will address the state-of-the-art knowledge and emerging opportunities for the development and demonstration of advanced neural electrodes.

Keywords

neural interface --- silicon carbide --- robust microelectrode --- microelectrode array --- liquid crystal elastomer --- neuronal recordings --- neural interfacing --- micro-electromechanical systems (MEMS) technologies --- microelectromechanical systems --- neuroscientific research --- magnetic coupling --- freely-behaving --- microelectrodes --- in vivo electrophysiology --- neural interfaces --- enteric nervous system --- conscious recording --- electrode implantation --- intracranial electrodes --- foreign body reaction --- electrode degradation --- glial encapsulation --- electrode array --- microelectrodes --- neural recording --- silicon probe --- three-dimensional --- electroless plating --- intracortical implant --- microelectrodes --- stiffness --- immunohistochemistry --- immune response --- neural interface response --- neural interface --- micromachine --- neuroscience --- biocompatibility --- training --- education --- diversity --- bias --- BRAIN Initiative --- multi-disciplinary --- micro-electromechanical systems (MEMS) --- n/a --- silicon neural probes --- LED chip --- thermoresistance --- temperature monitoring --- optogenetics --- microfluidic device --- chronic implantation --- gene modification --- neural recording --- neural amplifier --- microelectrode array --- intracortical --- sensor interface --- windowed integration sampling --- mixed-signal feedback --- multiplexing --- amorphous silicon carbide --- neural stimulation and recording --- insertion force --- microelectrodes --- neural interfaces --- intracortical --- microelectrodes --- shape-memory-polymer --- electrophysiology --- electrode --- artifact --- electrophysiology --- electrochemistry --- fast-scan cyclic voltammetry (FSCV) --- neurotechnology --- neural interface --- neuromodulation --- neuroprosthetics --- brain-machine interfaces --- intracortical implant --- microelectrodes --- softening --- immunohistochemistry --- immune response --- neural interface --- shape memory polymer --- deep brain stimulation --- fast scan cyclic voltammetry --- dopamine --- glassy carbon electrode --- magnetic resonance imaging --- system-on-chip --- neuromodulation --- bidirectional --- closed-loop --- sciatic nerve --- vagus nerve --- precision medicine --- neural probe --- intracortical --- microelectrodes --- bio-inspired --- polymer nanocomposite --- cellulose nanocrystals --- photolithography --- Parylene C --- impedance --- Utah electrode arrays --- electrode–tissue interface --- peripheral nerves --- wireless --- implantable --- microstimulators --- neuromodulation --- peripheral nerve stimulation --- neural prostheses --- microelectrode --- neural interfaces --- dextran --- neural probe --- microfabrication --- foreign body reaction --- immunohistochemistry --- polymer --- chronic --- electrocorticography --- ECoG --- micro-electrocorticography --- µECoG --- neural electrode array --- neural interfaces --- electrophysiology --- brain–computer interface --- in vivo imaging --- tissue response --- graphene --- n/a

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english (3)


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2020 (1)

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