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The Special Issue on “Model-Based Tools for Pharmaceutical Manufacturing Processes” will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This book provides a collection of nine papers on original advances in the model-based process unit, system-level, quality-by-design under uncertainty, and decision-making applications of pharmaceutical manufacturing processes.

pharmaceutical processes --- flexibility analysis --- probabilistic design space --- global optimization --- model integration --- flowsheet modeling --- sensitivity analysis --- continuous manufacturing --- wet granulation --- Amoxicillin --- enzymatic synthesis --- non-isothermal modelling --- parameter estimation --- dynamic optimisation --- enzymatic reaction --- reversible reaction --- dynamic modelling --- pyrimidine-nucleoside phosphorylase --- spectroscopic assay --- process kinetics --- ODE model --- process design --- single-use technology --- parenteral manufacturing --- MATLAB Production Server --- software development --- multi-objective decision-making --- robust process design --- batch-to-batch variation --- parametric probability-box --- point estimate method --- pharmaceutical manufacturing --- freeze-drying --- quality by design --- pharmaceutical manufacturing --- polynomial chaos --- global sensitivity analysis --- spray drying --- process modeling --- return on investment --- diffusion of innovation --- residence time distribution --- continuous stirred tank reactor --- bypassing --- Fourier analysis --- continuous manufacturing --- n/a

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The overall goal of this book is to give the reader a state-of-the-art synopsis of the pharmacist services domain. To accomplish this goal, the authors have addressed the social, psychosocial, political, legal, historic, clinical, and economic factors that are associated with pharmacist services. In this book, you will gain cutting-edge insights from learning about the research of experts throughout the world. The findings have relevance for enhancing pharmacist professionalism, pharmacist practice, and the progression of pharmacist services in the future.

ambulatory care --- pharmacy practice faculty --- pharmacy learners --- clinical practice --- pharmacist services --- community pharmacy practice --- dispensing --- counselling --- pharmaceutical intervention --- pharmaceutical care --- observation --- immunization programs --- mobile health units --- experiential learning --- billing --- healthy people 2020 --- pharmacy --- emergency unit --- health workers --- cystic fibrosis --- pharmacists --- pharmacy services, medication management --- medication use burden --- travel --- immunization --- vaccination --- pharmacist --- community pharmacy --- pharmacy intern --- student pharmacist --- primary care --- interprofessional --- federally qualified health center --- serviced marketing --- design thinking --- medication synchronization --- community pharmacists --- innovation science --- adherence --- competitive advantage --- age disparities --- gender disparities --- job satisfaction --- job-related preferences --- pharmacist workforce --- pharmacists --- pharmacy education --- interprofessional practice and education --- community pharmacy --- medication therapy management --- medication-related problems --- medication discrepancies --- continuity of patient care --- cost avoidance --- Comprehensive Medication Management --- pharmaceutical care --- primary health care --- chronic diseases --- clinical results --- naltrexone --- opioid use disorder --- implementation --- service process --- regulatory --- community pharmacy --- pharmacist services --- opioid --- communication --- naloxone --- misuse --- disposal --- safety --- counseling --- comprehensive medication review --- community pharmacy --- collaboration --- community pharmacy --- pharmaceutical care --- medication therapy management --- pharmacy practice --- pharmacy education --- grants --- pharmacy benefit manager (PBM) --- ethics --- pharmaceutical regulation --- health care policy --- decision-making --- organizations --- ethical models --- code of ethics --- pharmacist --- adverse drug events --- brown bag --- pharmacy --- medication reconciliation --- pharmacy clinical services --- comprehensive medication management services --- medication experience --- pharmaceutical care practice --- documentation --- focus groups --- community pharmacy --- retail clinics --- pharmacists --- nurse practitioners --- interprofessional training --- primary care --- healthcare access --- community pharmacy --- pharmacist services --- wellness programs --- medication adherence --- quality measurement/benchmarking --- multiple chronic conditions --- CMS Star rating --- chronic kidney disease --- interprofessional care --- quality assurance --- pharmacy communication --- cue orientation --- focus group interviews --- Denmark --- transitions in care --- pharmacist --- medication therapy problems --- medication safety --- comprehensive medication management --- readmissions --- intention --- medication therapy management --- pharmacy services --- South Asian --- theory of planned behavior. --- pharmacist services --- community pharmacy --- care plan --- compensation --- primary health care --- information sharing --- qualitative research --- comparative case study --- value --- human papilloma virus --- HPV vaccination --- pharmacy --- coordinated care --- history of pharmacy --- 20th century history --- 21st century history --- community pharmacy services --- pharmacy education --- pharmacist --- services marketing --- management --- value-added services --- community-based pharmacy --- community-based pharmacist practitioners --- community pharmacy services --- health policy --- interrupted time series analysis --- medication reconciliation --- mental health care --- pharmacy staff --- mental health first aid --- mental illness --- pharmacist roles --- n/a --- collaborative practice --- clinical pharmacy --- advanced practice pharmacist provider

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The toxicity and fate of pharmaceuticals and other emerging micro-organic contaminants in the natural and built environments have been the focus of much research over the last twenty years. Particular focus has recently centred on the fate of antimicrobial chemicals, including antibiotics and antifungals. The occurrence of such chemicals in the environment is thought to contribute to the selection of resistance in exposed microorganisms.This Special Issue (SI) brings together a broad range of recent advances in the field of emerging micro-organic contaminants, ranging from medicinal contaminants to industrial chemicals in the environment. Notably, these range from chemical extraction and large-scale analysis to adverse effects on non-target aquatic organisms and potential risk to humans via contaminated foodstuffs. Additionally, this Special Issue also presents novel contaminant treatment/degradation methods of both physical and biological nature.

chitosan --- Pseudomonas putida --- immobilization --- dye decolorization --- degradation --- biosorption --- wastewater --- qPCR --- tetracyclines --- beta-lactams --- ARGs --- Escherichia coli --- water quality --- Membrane Bioreactor --- GAC-biofilter --- sewage treatment --- micropollutants --- pharmaceutical residues --- activated carbon --- picolinic acid --- biodegradation --- Rhodococcus --- 6-hydroxypicolinic acid --- pharmaceuticals --- organic pollutants --- liquid chromatography tandem mass spectrometry --- validation --- global monitoring --- vitellogenin (VTG) --- crustacean --- di(2-ethylhexyl) phthalate (DEHP) --- bisphenol A (BPA) --- irgarol --- espresso coffee machine extraction --- pressurized hot water extraction --- pharmaceuticals --- antibiotics --- hormones --- sewage sludge --- ion suppression --- UPLC MS/MS --- basic buffer --- veterinary drug --- residue --- shrimp --- mass spectrometry --- risk assessment --- perfluorinated compounds --- coagulation --- ozone --- chlorination --- activated carbon --- n/a --- ethyl tert-butyl ether --- ETBE biodegradation --- bacterial community --- polluted aquifer --- fuel oxygenates --- ethB gene

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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

procainamide --- N-acetylprocainamide --- ultra-high-pressure liquid chromatography --- rat --- plasma --- pharmacokinetics --- adalimumab --- immunoprecipitation --- liquid chromatography-quadrupole TOF MS --- bioanalysis --- GB3 --- Fabry disease --- LC-QTOF-MS/MS --- B6 --- 129-Glatm1Kul/J --- cytochrome P450 --- drug interaction --- liquid chromatography-tandem mass spectrometry --- organic anion transporting polypeptide --- pharmacokinetics --- Korean red ginseng extract --- metformin --- diabetes --- drug interaction --- pharmacokinetics --- efficacy --- ethyl glucuronide --- hair --- HPLC-MS/MS --- AUDIT score --- alcohol addiction --- eurycomanone --- Eurycoma longifolia --- bioavailability --- pharmacokinetic --- anthraquinone --- glycoside --- aglycone --- LC-MS/MS --- plasma --- protein precipitation --- loxoprofen --- CYP --- UGT --- human liver microsomes --- LC-HR/MS --- mematine --- drug interaction --- liquid chromatography-tandem mass spectrometry --- pharmacokinetics --- biopharmaceuticals --- drying technology --- protein stability --- bioavailability --- pharmacokinetics --- DA-9805 --- saikosaponin a --- paeonol --- imperatorin --- pharmacokinetics --- brain distribution --- Osthenol --- CYP --- UGT --- human liver microsomes --- glucuronidation --- Stauntonia hexaphylla leaf extract --- YRA-1909 --- pharmacokinetics --- chlorogenic acid --- neochlorogenic acid --- cryptochlorogenic acid --- caffeic acid --- caffeic acid O-glucuronides --- LC-MS/MS --- aceclofenac --- diclofenac --- esomeprazole --- pharmacokinetics --- gastric ulcer --- acetyl tributyl citrate --- pharmaceutical excipient --- pharmacokinetics --- metabolic stability --- plasma

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Heterogeneous catalysis, exploiting photo- and electrochemical reactions, has expanded rapidly in recent decades, having undergone various developments, especially from both energetic and environmental points of view. Photocatalysis plays a pivotal role in such applications as water splitting and air/water remediation. Electrocatalysis can be found in a large array of research fields, including the development of electroanalytical sensors, wastewater treatment, and energy conversion devices (e.g., batteries, fuel and solar cells, etc.). Therefore, the fine control of the synthetic procedures, together with extensive physicochemical characterisations of the tailor-made catalytic nanomaterials, are of fundamental importance to achieving the desired results. The present book will include recent enhancements in oxide/metal nanoparticles for photocatalytic and electrocatalytic applications, especially in the fields of pollutants abatement and energy conversion.

cobalt phosphate --- tantalum oxynitride --- water oxidation --- photoelectrochemistry --- solid-state synthesis --- photocatalytic selective oxidation --- Ti–C bonds --- hydrogen titanate --- benzylic alcohols --- interfacial charge transfer --- photocatalysis --- black TiO2 --- oxygen vacancies --- photodegradation --- Bi4Ti3O12 nanosheets --- photocatalytic hydrogen evolution --- solid-state chemical reduction --- oxygen vacancy --- Ga2O3 --- porous --- Cr(VI) --- organic pollutants --- rutile --- active facets --- pharmaceutical --- degradation --- mineralization --- active species --- nanocomposites --- Zn2SnO4/BiOBr --- visible light --- photocatalytic performance --- photocatalytic degradation --- g-C3N4 --- mesoporous Nb2O5 --- organic pollutant --- CaIn2S4/ZnIn2S4 composites --- Cr(VI) --- photocatalysis --- simulated sunlight --- hydrothermal method --- noble metal nanoparticles --- core-shell structures --- photodeposition --- magnetron sputtering --- photocatalysis --- hydrogen production --- localized surface plasmon resonance --- structure-property relationships --- heterogeneous photocatalysis --- TiO2 --- ascorbic acid --- surface modification --- band gap energy --- Alizarin Red S --- oxygen reduction reaction --- Pt-free catalysts --- CNT N-doped carbons --- active site hydrophilicity --- micrometric TiO2 --- Mn decoration --- visible light photocatalysis --- impregnation pH --- surface hydroxyl groups