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Soft Tissue and Bone Sarcoma

ISBN: 9783906980461 9783906980584 Year: Pages: 156 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:17:42
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Soft tissue and bone sarcomas disproportionately affect children, adolescents, and young adults. Although considered a rare disease, sarcomas continue to have a devastating effect on these patients and their loved ones, and their impact on our society far exceed their relatively low prevalence. Because of its rarity and heterogeneity, clinical decision making on management of sarcomas are often individualized and without a consensus treatment strategy. Furthermore, research to improve clinical outcomes are particularly challenging as sizeable studies are hard to produce. By improving our knowledge about the molecular biology of sarcomas, we hope to identify new treatment strategies and targets for further drug development. [...]

Geothermal Energy: Delivering on the Global Potential

ISBN: 9783038421337 9783038421344 Year: Pages: 430 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-20 14:48:30
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After decades of being largely the preserve of countries in volcanic regions, the use of geothermal energy—for both heat and power applications—is now expanding worldwide. This reflects its excellent low-carbon credentials and its ability to offer baseload and dispatchable output - rare amongst the mainstream renewables. Yet uptake of geothermal still lags behind that of solar and wind, principally because of (i) uncertainties over resource availability in poorly-explored reservoirs and (ii) the concentration of full-lifetime costs into early-stage capital expenditure (capex). Recent advances in reservoir characterization techniques are beginning to narrow the bounds of exploration uncertainty, both by improving estimates of reservoir geometry and properties, and by providing pre-drilling estimates of temperature at depth. Advances in drilling technologies and management have potential to significantly lower initial capex, while operating expenditure is being further reduced by more effective reservoir management — supported by robust mathematical models — and increasingly efficient energy conversion systems (flash, binary and combined-heat-and-power). Advances in characterization and modelling are also improving management of shallow low-enthalpy resources that can only be exploited using heat-pump technology. Taken together with increased public appreciation of the benefits of geothermal, the technology is finally ready to take its place as a mainstream renewable technology, This book draws together some of the latest developments in concepts and technology that are enabling the growing realisation of the global potential of geothermal energy in all its manifestations.After decades of being largely the preserve of countries in volcanic regions, the use of geothermal energy—for both heat and power applications—is now expanding worldwide. This reflects its excellent low-carbon credentials and its ability to offer baseload and dispatchable output - rare amongst the mainstream renewables. Yet uptake of geothermal still lags behind that of solar and wind, principally because of (i) uncertainties over resource availability in poorly-explored reservoirs and (ii) the concentration of full-lifetime costs into early-stage capital expenditure (capex). Recent advances in reservoir characterization techniques are beginning to narrow the bounds of exploration uncertainty, both by improving estimates of reservoir geometry and properties, and by providing pre-drilling estimates of temperature at depth. Advances in drilling technologies and management have potential to significantly lower initial capex, while operating expenditure is being further reduced by more effective reservoir management — supported by robust mathematical models — and increasingly efficient energy conversion systems (flash, binary and combined-heat-and-power). Advances in characterization and modelling are also improving management of shallow low-enthalpy resources that can only be exploited using heat-pump technology. Taken together with increased public appreciation of the benefits of geothermal, the technology is finally ready to take its place as a mainstream renewable technology.

The Role of Play in Children’s Health and Development

ISBN: 9783038421818 9783038421825 Year: Volume: 1st Pages: 200 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 11:40:05
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ZEMCH Research Initiatives: Mass Customisation and Sustainability

ISBN: 9783038421115 9783038421122 Year: Pages: 254 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-11-16 12:10:38
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The earth is experiencing the adverse effect of climate change. In response to growing global warming issues and the constant increase of energy prices, house-builders and housing manufacturers today are becoming more responsive to the delivery of net zero energy and carbon dioxide emission sustainable homes than ever. Within this context, the sustainability may embrace housing economy and adequacy beyond the legitimacy in which the quality barely coincides with individuals' dynamic various needs, desires and expectations. In this special issue, 'mass customisation' is reviewed being considered as a paradoxical concept which has been recognised as a means to lessen production costs of end-user products whilst achieving the customisability through economies of scope rather than economies of scale. Nevertheless, the housing industry's business operation tends to follow routines and the close system mode of operation often hinders the enterprises from adopting unfamiliar inn ovations which may be inevitable in realising the delivery and operation of socially, economically and environmentally sustainable homes. In order to deliver a marketable and replicable zero energy/emission mass custom home, or ZEMCH, the strategic balance between the optional and standard features seems to be critical. The optional features may be provided with the aim to enhance design quality (or customizability) that helps contribute to satisfying desires and expectations of individual stakeholders. The standard equipment, on the other hand, needs to be installed in buildings as it aims to exceed product quality whose levels can be adjusted in conjunction with societal demands and requirements. This edition encompasses a wide spectrum of hopes and fears around the design, production and marketing approaches to the ZEMCH delivery and operation, and showcases some exemplars budding out in different climates around the globe

Sustainability in China: Bridging Global Knowledge with Local Action

ISBN: 9783038421139 9783038421146 Year: Pages: 332 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences
Added to DOAB on : 2016-05-09 15:17:13
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China’s road to sustainability has attracted global attention. Since the “Reform & Opening Up” policy, China’s rapid pace of both urbanization and industrialization has made its being the second largesteconomy but meantime a heavy environmental price has been paid over the past few decades for addressing the economic developmental target. Today, as the biggest developing country, China needs to take more responsibilities for constructing its local ecological-civilization society as well as for addressingthe global challenges such as climate change, resources scary and human beings well-fare; therefore, weneed to have deeper understandings into China’s way to sustainability at very different levels, bothspatially and structurally, concerns ranging from generating sustainable household livelihoods to globalclimate change, from developing technological applications to generate institutional changes. In thisspirit, this publication, “Sustainability in China: Bridging Global Knowledge with Local Action” aims to investigate the intended and spontaneous issues concerning China’s road to sustainability in a combined top-down and bottom-up manner, linking international knowledge to local-based studies.

Enzymes and Their Biotechnological Applications

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ISBN: 9783038421481 9783038421474 Year: Pages: 468 DOI: 10.3390/books978-3-03842-147-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 12:11:22
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