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Atopological Trilogy: Deleuze and Guattari

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ISBN: 9780692403723 Year: Pages: 90 DOI: 10.21983/P3.0096.1.00 Language: English
Publisher: punctum books
Subject: Philosophy
Added to DOAB on : 2019-06-12 09:24:39
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Atopological Trilogy creates new concepts for Deleuze-Guattarian thought without any heed for sectarian, sermonising, or dutiful readings of the philosophers. In Part I of the trilogy, “Becoming-Sexual of the Sexual,” Aracagök demonstrates the ways in which quantum theory and the concept of “complementarity” inform Deleuze and Guattari’s thought, especially in relation to “becoming” in general and “becoming-woman” and “becoming-queer” more particularly. Aracagök argues that the ways in which the philosophers put forward a ban on “becoming-man” with a certain degree of undecidability encapsulates (albeit in a cryptic form) other becomings, the most important of which is becoming-queer, or rather, the becoming-sexual of the sexual. In Part II: “Deleuze on Sound, Music, and Schizo-Incest,” Aracagök puts into resonance the sound, noise, and music (and the question) of schizo-incest with the intention of deterritorialising a notion of the meta-audible. If Kafka’s story, “The Investigations of a Dog” leads us to a realm of the “formless” which cannot be heard without destroying what we know as “hearing,” it also offers us a limit-experience of the meta-audible, which, when radicalised via the notions of “schizo-incest” and “self-shattering,” creates a line of flight that escapes even from the line of flight itself. All these maneuvers pose a serious challenge to Deleuze and Guattari, who claim that despite all his investigations, Kafka’s investigator dog is re-Oedipalised in the end. Proposing in the end a limit experience which Aracagök calls the “meta-audible,” he shows that Kafka’s more radical approach to sound creates a line of flight that escapes even from the line of flight itself

Aging, neurogenesis and neuroinflammation in hearing loss and protection

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196449 Year: Pages: 151 DOI: 10.3389/978-2-88919-644-9 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
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Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease. In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes to molecules involved in aging. Oxidative stress takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.

Manipulative approaches to human brain dynamics

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194797 Year: Pages: 246 DOI: 10.3389/978-2-88919-479-7 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-03-10 08:14:33
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In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.

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