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Improving outcomes in cerebral palsy with early intervention: new translational approaches

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195121 Year: Pages: 155 DOI: 10.3389/978-2-88919-512-1 Language: English
Publisher: Frontiers Media SA
Subject: Pediatrics --- Medicine (General) --- Neurology
Added to DOAB on : 2015-12-03 13:02:24
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The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life.CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry. CP may be viewed as aberrant plasticity in response to a lesion, indeed, abnormalities in movement are subtle at first but develop subsequently. It is misleading to suppose that developmental mechanisms are self-reparative. The challenge is to understand activitydependent fine tuning of neural circuitry during normal development and to find how to promote desirable plasticity whilst limiting undesirable effects following developmental lesions. However, before proposing interventions, we have to develop our ability to predict the severity of neonatal insults.We solicited a variety of articles, including long and short reviews, original research and opinion pieces, from both basic scientists and clinicians. Likewise we, as editors, have complementary knowledge and experience in this area. Anna Basu is an academic pediatric neurologist and Gavin Clowry is a developmental neuroscientist.

Nutrition and prevention of Alzheimer's disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197194 Year: Pages: 76 DOI: 10.3389/978-2-88919-719-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Altered metabolism is known to be associated with a higher incidence of Alzheimer´s disease (AD). Diabetes type 2, obesity, and metabolic syndrome are considered risk factors for the development of dementias, including AD. These metabolic diseases may have a genetic predisposition, but most of them are caused by environmental factors and life-style. Most research has focused on the effect of a high-fat diet (HFD) and sweetened beverages that induce obesity. Importantly, a HFD can also trigger oxidative stress, neuro-inflammation and cognitive decline. Less is known, however, about beneficial effects of diet on cognition, such as slowing the progression or preventing AD by ingesting whole fruits, vegetables, fish and oil. It is important to highlight the difference between vitamin/mineral supplements and whole food, as it appears that the former are clinically ineffective, while multiple ingredients in the latter act synergistically to improve cognition. As AD is a disease of slow progression, therapies should start several decades before clinical symptoms can be observed; one strategy can be the ingestion of healthy food in those subjects with one or more risk factors (genetic, environmental, life-style) already in their 40s, just when some brain metabolic disturbances start to develop. This dietary therapy can overcome the increased reactive oxygen species, protein deposition and synaptic failure, characteristic of AD. This research topic will cover a range of research articles, case studies, opinion and mini-reviews, all focused on describing the damaging effects of an industrial diet on cognition as well as on highlighting the beneficial effects of a healthy diet to prevent AD. We believe that we still have time to fight against the negative impact of our industrialized cultures, and adopt better eating habits, increase exercise and slow down our life style to prevent increasing dementia in the aging population. Also, all these topics has been a product of intensives investigations, with a great life hope, and we hope you all enjoy reading this e-book.

Keywords

Cognition --- Diet --- Vitamins --- Minerals --- Functional Food --- Dementia --- Aging --- biomarkers --- diagnosis

Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 DOI: 10.1007/978-3-319-19132-4 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2016-03-15 10:53:40
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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Epidemiology (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Pathogenesis (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

References (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Treatment (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Diagnosis (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:47

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Prevention (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:47

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Preface (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:47

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

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