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Structural and computational glycobiology: immunity and infection

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196388 Year: Pages: 102 DOI: 10.3389/978-2-88919-638-8 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2015-10-30 16:33:44
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Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on structural and computational approaches to understanding carbohydrate recognition by proteins involved in immunity and infection. Particular areas of focus include cancer immunotherapeutics, carbohydrate-lectin interactions, glycosylation and glycosyltransferases.

What can simple brains teach us about how vision works

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196784 Year: Pages: 290 DOI: 10.3389/978-2-88919-678-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
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Vision is the process of extracting behaviorally-relevant information from patterns of light that fall on retina as the eyes sample the outside world. Traditionally, nonhuman primates (macaque monkeys, in particular) have been viewed by many as the animal model-of-choice for investigating the neuronal substrates of visual processing, not only because their visual systems closely mirror our own, but also because it is often assumed that “simpler” brains lack advanced visual processing machinery. However, this narrow view of visual neuroscience ignores the fact that vision is widely distributed throughout the animal kingdom, enabling a wide repertoire of complex behaviors in species from insects to birds, fish, and mammals. Recent years have seen a resurgence of interest in alternative animal models for vision research, especially rodents. This resurgence is partly due to the availability of increasingly powerful experimental approaches (e.g., optogenetics and two-photon imaging) that are challenging to apply to their full potential in primates. Meanwhile, even more phylogenetically distant species such as birds, fish, and insects have long been workhorse animal models for gaining insight into the core computations underlying visual processing. In many cases, these animal models are valuable precisely because their visual systems are simpler than the primate visual system. Simpler systems are often easier to understand, and studying a diversity of neuronal systems that achieve similar functions can focus attention on those computational principles that are universal and essential. This Research Topic provides a survey of the state of the art in the use of animal models of visual functions that are alternative to macaques. It includes original research, methods articles, reviews, and opinions that exploit a variety of animal models (including rodents, birds, fishes and insects, as well as small New World monkey, the marmoset) to investigate visual function. The experimental approaches covered by these studies range from psychophysics and electrophysiology to histology and genetics, testifying to the richness and depth of visual neuroscience in non-macaque species.

Individual Differences in Speech Production and Perception

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Book Series: Speech Production and Perception ISBN: 9783653963830 9783653963847 9783631665060 Year: Pages: 284 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Biology --- Psychology --- Linguistics
Added to DOAB on : 2019-01-15 13:32:55
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Inter-individual variation in speech is a topic of increasing interest both in human sciences and speech technology. It can yield important insights into biological, cognitive, communicative, and social aspects of language. Written by specialists in psycholinguistics, phonetics, speech development, speech perception and speech technology, this volume presents experimental and modeling studies that provide the reader with a deep understanding of interspeaker variability and its role in speech processing, speech development, and interspeaker interactions. It discusses how theoretical models take into account individual behavior, explains why interspeaker variability enriches speech communication, and summarizes the limitations of the use of speaker information in forensics.

Pattern recognition receptors and cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196746 Year: Pages: 201 DOI: 10.3389/978-2-88919-674-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-08-16 10:34:25
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The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field.

Detection and Tracking of Targets in Forward-Looking InfraRed (FLIR) Imagery

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ISBN: 9783038420521 9783038420538 Year: Pages: XIV, 228 DOI: 10.3390/books978-3-03842-053-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 07:34:37
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Detection and tracking of targets in forward looking infrared (FLIR) imagery are challenging tasks. IR sensors often provide low signal-to-noise ratio and heavy background cluttering images. Non-stationary cameras can introduce further challenges, because detection and tracking might make it necessary to properly deal with sensor ego-motion through suitable estimation and compensation techniques. Moreover, further issues are posed by imagery with multiple and possibly moving target and non-target objects, which can blend into the background, change their signature, size, shape, and even overlap during their motion. Finally, specific applications could introduce cumbersome real-time constraints, thus requiring tracking techniques with a reduced computational footprint.The objective of this Special Issue is to invite high state-of-the-art research contributions, tutorials, and position papers that address the broad challenges faced in analysis and processing of FLIR imagery. Original papers describing completed and unpublished work that are not currently under review by any other journal/magazine/conference/special issue are solicited.

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