Search results: Found 19

Listing 1 - 10 of 19 << page
of 2
>>
Sort by
Theories of Visual Attention - linking cognition, neuropsychology, and neurophysiology

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196371 Year: Pages: 112 DOI: 10.3389/978-2-88919-637-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2016-08-16 10:34:25
License:

Loading...
Export citation

Choose an application

Abstract

The Neural Theory of Visual Attention of Bundesen, Habekost, and Kyllingsbæk (2005) was proposed as a neural interpretation of Bundesen’s (1990) theory of visual attention (TVA). In NTVA, visual attention functions via two mechanisms: by dynamic remapping of receptive fields of cortical cells such that more cells are devoted to behaviorally important objects than to less important ones (filtering) and by multiplicative scaling of the level of activation in cells coding for particular features (pigeonholing). NTVA accounts for a wide range of known attentional effects in human performance and a wide range of effects observed in firing rates of single cells in the primate visual system and thus provides a mathematical framework to unify the 2 fields of research. In this Research Topic of Frontiers in Psychology, some of the leading theories of visual attention at both the cognitive, neuropsychological, and neurophysiological levels are presented and evaluated. In addition, the Research Topic encompasses application of the framework of NTVA to various patient populations and to neuroimaging as well as genetic and psychopharmacological studies.

Keywords

neural --- visual --- Attention --- computational --- Model

New treatment perspectives in autism spectrum disorders

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195305 Year: Pages: 161 DOI: 10.3389/978-2-88919-530-5 Language: English
Publisher: Frontiers Media SA
Subject: Pediatrics --- Medicine (General)
Added to DOAB on : 2015-12-10 11:59:06
License:

Loading...
Export citation

Choose an application

Abstract

Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.

Schizophrenia: A Consequence of Gene-Environment Interactions?

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195312 Year: Pages: 126 DOI: 10.3389/978-2-88919-531-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2015-12-10 11:59:06
License:

Loading...
Export citation

Choose an application

Abstract

Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems.

Sub-cellular Proteomics

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193028 Year: Pages: 254 DOI: 10.3389/978-2-88919-302-8 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
License:

Loading...
Export citation

Choose an application

Abstract

Whilst significant advances have been made in whole organismal proteomics approaches, many researchers still rely on combinations of tissue selection and subcellular prefractionation methods to reduce the complexity of protein extracts from plants prior to proteomic analysis. Often this will allow identification of many lower abundance proteins of the target proteome and it may involve the selection of specific organs, cell types or the isolation of specific subcellular components. These subcellular proteomes provide insight into functions following various treatments and also contribute to the wider understanding of the entire organismal proteome by cataloguing a series of sub-proteome contents. The aim of this Research Topic is to bring together knowledge of sub cellular components in different plant species to provide a basis for accelerated research. It aims to provide a mini-review for each proposed section that summarizes the current understanding of a particular proteome, with the anticipation that every 5 - 10 years we can update these definitive publications.

On the Use of Model Order Reduction Techniques for the Elastohydrodynamic Contact Problem

Author:
Book Series: Schriftenreihe des Instituts für Technische Mechanik, Karlsruher Institut für Technologie ISSN: 16143914 ISBN: 9783731503699 Year: Volume: 27 Pages: XXXII, 125 p. DOI: 10.5445/KSP/1000046871 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
License:

Loading...
Export citation

Choose an application

Abstract

The objective of this work is to develop a method which solves the nonlinear elastohydrodynamic contact problem in a fast and precise way using model order reduction techniques. The reduction procedure is based on a projection onto a low-dimensional subspace using different hyper-reduction procedures. The method provides fast and highly accurate reduced order models for stationary and transient, Newtonian and Non-Newtonian EHD line and point contact problems.

Modellbasierte Entwicklung funktional sicherer Hardware nach ISO 26262

Author:
Book Series: Steinbuch Series on Advances in Information Technology / Karlsruher Institut für Technologie, Institut für Technik der Informationsverarbeitung ISSN: 21914737 ISBN: 9783731504429 Year: Volume: 10 Pages: VI, 291 p. DOI: 10.5445/KSP/1000049863 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:57
License:

Loading...
Export citation

Choose an application

Abstract

The compliance with functional safety according to the standard ISO 26262 in context of the increasing electrification of road vehicles is a significant challenge. This work provides a concept and methodology for the model-based development of functional safe hardware. This is characterized by the description of hardware designs, annotation of failure data and performing the demanded safety evaluations.

Model Transformation Languages with Modular Information Hiding

Author:
Book Series: The Karlsruhe Series on Software Design and Quality / Ed. by Prof. Dr. Ralf Reussner ISSN: 18670067 ISBN: 9783731503460 Year: Volume: 17 Pages: XX, 360 p. DOI: 10.5445/KSP/1000045910 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:02:02
License:

Loading...
Export citation

Choose an application

Abstract

Model transformations, together with models, form the principal artifacts in model-driven software development. Industrial practitioners report that transformations on larger models quickly get sufficiently large and complex themselves. To alleviate entailed maintenance efforts, this thesis presents a modularity concept with explicit interfaces, complemented by software visualization and clustering techniques. All three approaches are tailored to the specific needs of the transformation domain.

Vergil's Political Commentary in the Eclogues, Georgics and Aeneid

Author:
ISBN: 9783110426427 9783110456134 Year: Pages: 183 DOI: 10.1515/9783110426427 Language: English
Publisher: De Gruyter
Subject: Languages and Literatures
Added to DOAB on : 2015-08-11 08:52:53
License:

Loading...
Export citation

Choose an application

Abstract

In the book titled Vergil's political commentary in Eclogues, Georgics and Aeneid, the author examines Vergil’s political views by analyzing the whole of the poet’s work. He introduces the notion of the functional model suggesting that the poet often used this instrument when making a political statement. New interpretations of a number of the Eclogues and passages of the Georgics and the Aeneid are suggested and the author concludes that Vergil’s political engagement is visible in much of his work. During his whole career the poet was consistent in his views on several major political themes. These varied from, the distress caused by the violation of the countryside during and after the expropriations in the 40s B.C., to the horrors of the civil war and the violence of war in general, and the necessity of strong leadership. Vergil hoped and expected that Octavian would establish peace and order, and he supported a form of hereditary kingship for which he considered Octavian a suitable candidate. He held Cleopatra in high regard, and he appreciated a more meaningful role for women in society. Vergil wrote poetry that supported Augustus, but he had also the courage to criticize Octavian and his policies. He was a commentator with an independent mind and was not a member of Augustus’ putative propaganda machine.

Habituation mechanisms and their impact on cognitive function

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194629 Year: Pages: 110 DOI: 10.3389/978-2-88919-462-9 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
License:

Loading...
Export citation

Choose an application

Abstract

Habituation describes the progressive decrease of the amplitude or frequency of a motor response to repeated sensory stimulation that is not caused by sensory receptor adaptation or motor fatigue. Habituation can occur in different time scales: habituation within a testing session has been termed short-term habituation, whereas habituation across testing sessions has been termed long-term habituation. Generally, the more spaced the stimuli for inducing habituation are presented (i.e. the slower habituation is induced), the longer it seems to take to recover the behavioural response to its initial magnitude. Habituation is opposed by behavioural sensitization, which is thought to be an independent mechanism that leads to an increased behavioural response, especially if the sensory stimulus is annoying or aversive. Habituation provides an important mechanism for filtering sensory information, as it allows filtering out irrelevant stimuli and thereby focussing on important stimuli, a prerequisite for many cognitive tasks. The importance is demonstrated in mental disorders that are associated with disruptions in habituation, e.g. schizophrenia and autism spectrum disorders. The inability to filter out irrelevant information in patients with these disorders strongly correlates with disruptions in higher cognitive functions, such as in different types of memory and attention. Habituation is also considered to be the most basic form of non-associative implicit learning, and it can be observed throughout the animal kingdom. Based on the importance of habituation for cognitive function and therefore for the survival of an animal, it is assumed that habituation mechanisms are highly conserved across species. On the other hand, there is emerging evidence for a multitude of homo- and heterosynaptic mechanisms underlying habituation, depending on the modality of sensory stimulation, the level of sensory information processing where habituation occurs, and the temporal composition of sensory stimulation. Eric Kandel used the sea hare Aplysia in order to study habituation mechanisms of the gill withdrawal reflex; however, the molecular mechanisms remain largely elusive to date. A multitude of different organisms, behaviours, and experimental approaches have been used since in order to study habituation, but still surprisingly little is known about the underlying mechanisms. New insights also come from an unexpected side: in the recent past, groups that have been studying molecular mechanisms underlying short- and long-term synaptic plasticity phenomenons in different parts of the rodent brain are starting to link these plasticity processes to behavioural habituation. The scope of this Frontier Research Topic is to give an overview over the concept of habituation, different animal and behavioural models used for studying habituation mechanisms, as well as the different synaptic and molecular processes suggested to play a role in behavioural habituation through Original Research Articles, Methods, Hypothesis & Theory Articles, and Reviews.

Neuro-motor control and feed-forward models of locomotion in humans

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196142 Year: Pages: 190 DOI: 10.3389/978-2-88919-614-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
License:

Loading...
Export citation

Choose an application

Abstract

Locomotion involves many different muscles and the need of controlling several degrees of freedom. Despite the Central Nervous System can finely control the contraction of individual muscles, emerging evidences indicate that strategies for the reduction of the complexity of movement and for compensating the sensorimotor delays may be adopted. Experimental evidences in animal and lately human model led to the concept of a central pattern generator (CPG) which suggests that circuitry within the distal part of CNS, i.e. spinal cord, can generate the basic locomotor patterns, even in the absence of sensory information. Different studies pointed out the role of CPG in the control of locomotion as well as others investigated the neuroplasticity of CPG allowing for gait recovery after spinal cord lesion. Literature was also focused on muscle synergies, i.e. the combination of (locomotor) functional modules, implemented in neuronal networks of the spinal cord, generating specific motor output by imposing a specific timing structure and appropriate weightings to muscle activations. Despite the great interest that this approach generated in the last years in the Scientific Community, large areas of investigations remain available for further improvement (e.g. the influence of afferent feedback and environmental constrains) for both experimental and simulated models. However, also supraspinal structures are involved during locomotion, and it has been shown that they are responsible for initiating and modifying the features of this basic rhythm, for stabilising the upright walking, and for coordinating movements in a dynamic changing environment. Furthermore, specific damages into spinal and supraspinal structures result in specific alterations of human locomotion, as evident in subjects with brain injuries such as stroke, brain trauma, or people with cerebral palsy, in people with death of dopaminergic neurons in the substantia nigra due to Parkinson’s disease, or in subjects with cerebellar dysfunctions, such as patients with ataxia. The role of cerebellum during locomotion has been shown to be related to coordination and adaptation of movements. Cerebellum is the structure of CNS where are conceivably located the internal models, that are neural representations miming meaningful aspects of our body, such as input/output characteristics of sensorimotor system. Internal model control has been shown to be at the basis of motor strategies for compensating delays or lacks in sensorimotor feedbacks, and some aspects of locomotion need predictive internal control, especially for improving gait dynamic stability, for avoiding obstacles or when sensory feedback is altered or lacking. Furthermore, despite internal model concepts are widespread in neuroscience and neurocognitive science, neurorehabilitation paid far too little attention to the potential role of internal model control on gait recovery. Many important scientists have contributed to this Research Topic with original studies, computational studies, and review articles focused on neural circuits and internal models involved in the control of human locomotion, aiming at understanding the role played in control of locomotion of different neural circuits located at brain, cerebellum, and spinal cord levels.

Listing 1 - 10 of 19 << page
of 2
>>
Sort by
Narrow your search
-->