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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

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Book Series: Lecture Notes in Computational Science and Engineering ISSN: 1439-7358 ISBN: 9783319300290 9783319300306 Year: Volume: 111 Pages: 261 DOI: 10.1007/978-3-319-30030-6 Language: English
Publisher: Springer Nature
Subject: Business and Management --- Geology --- Earth Sciences --- Computer Science --- Electrical and Nuclear Engineering --- Biotechnology --- Internal medicine --- Medical technology --- Therapeutics --- General and Civil Engineering
Added to DOAB on : 2017-02-15 18:39:18
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Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.

Glycan Diversity in Fungi, Bacteria and Sea Organisms

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199426 Year: Pages: 85 DOI: 10.3389/978-2-88919-942-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Internal medicine
Added to DOAB on : 2016-01-19 14:05:46
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The cell surface of fungi, bacteria and sea organisms is highly glycosylated. These glycans are oligo- or polysaccharide molecules that can be secreted or attached to protein or lipids forming glycoconjugates. They present extraordinary structural diversity that could explain their involvement in many fundamental cellular processes, including growth, differentiation and morphogenesis. Considerable advances have been made on the structural elucidation of these glycans. Their primary structures were determined based on a combination of mass spectrometry and NMR spectroscopy techniques. The combination of these sensitive and powerful techniques has allowed us to increase our structural knowledge of a wide variety of glycans expressed by different fungi, bacteria and sea organisms.

Computer and Information Sciences: 31st International Symposium, ISCIS 2016, Kraków, Poland, October 27–28, 2016, Proceedings

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Book Series: Communications in Computer and Information Science ISSN: 1865-0929 ISBN: 9783319472164 9783319472171 Year: Volume: 659 Pages: 278 DOI: 10.1007/978-3-319-47217-1 Language: English
Publisher: Springer Nature
Subject: Business and Management --- Transportation --- Manufactures --- Biotechnology --- Therapeutics --- Electrical and Nuclear Engineering
Added to DOAB on : 2017-03-08 12:46:55
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This book constitutes the refereed proceedings of the 31st International Symposium on Computer and Information Sciences, ISCIS 2016, held in Krakow, Poland, in October 2016.The 29 revised full papers presented were carefully reviewed and selected from 65 submissions. The papers are organized in topical sections on smart algorithms; data classification and processing; stochastic modelling; performance evaluation; queuing systems; wireless networks and security; image processing and computer vision.

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