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Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198207 Year: Pages: 129 DOI: 10.3389/978-2-88919-820-7 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair. DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.

Abschied vom Kalten Krieg? Die Sozialdemokraten und der Nachrüstungsstreit (1977-1987)

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Book Series: Schriftenreihe der Vierteljahrshefte für Zeitgeschichte ISSN: 05069408 ISBN: 9783110449303 Year: Volume: 112 Pages: 297 DOI: 10.1515/9783110449303 Language: German
Publisher: De Gruyter
Subject: History
Added to DOAB on : 2020-07-17 18:36:55

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The controversy about NATO`s Double-Track Decision unsettled West German society in the 1980s. It especially affected the Social Democrats, who were split between the policies of their Chancellor and the peace movement. The author draws on extensive sources to examine the dispute over the deployment of additional US atomic weapons. He argues that elements of the SPD viewed the Cold War as anachronistic long before it had actually come to an end.

Critical Earthquake Response of Elastic-Plastic Structures and Rigid Blocks under Near-Fault Ground Motions: Closed-Form Approach via Double Impulse

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Book Series: Frontiers Theme Book ISBN: 9782889198702 Year: Pages: 64 DOI: 10.3389/978-2-88919-870-2 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2016-01-19 14:05:46
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This eBook is the second in a series of books on the critical earthquake response of elastic-plastic structures or rigid blocks under near-fault ground motions, and includes four original research papers which were published in the specialty section Earthquake Engineering in ‘Frontiers in Built Environment’. Several extensions of the first book1 are included here. The first article is on the soil-structure interaction problem. The reduction of an original soil-structure interaction model into a single-degree-of-freedom (SDOF) model enables the application of the original theory for an SDOF model to such complicated soil-structure interaction model. The second article is concerned with the extension of the original theory for an SDOF model to a 2DOF model. Since the simple application of the original theory for an SDOF model to a multi-degree-of-freedom model is difficult due to out-of-phase phenomenon of multiple masses, a convex model theory is introduced and an upper bound of elastic-plastic response is derived. The third article is related to the stability problem of structures (collapse problems of structures) in which the P-delta effect is included. It is shown that the original theory for an SDOF model with elastic-perfectly plastic restoring-force characteristic can be applied to a model with negative second slope. The fourth article is an application of the energy balance approach to an overturning limit problem of rigid blocks. A closed-form expression of the overturning limit of rigid blocks is derived for the first time after the Housner’s pioneering work in 1963. The approach presented in this book, together with the first book, is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic and nonlinear range.

Critical Earthquake Response of Elastic-Plastic Structures Under Near-Fault Ground Motions: Closed-Form Approach via Impulse Input

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ISBN: 9782889197422 Year: Pages: 55 DOI: 10.3389/978-2-88919-742-2 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering
Added to DOAB on : 2017-08-30 10:14:31
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The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.

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