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Cardiac Remodeling: New Insights in Physiological and Pathological Adaptations

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453313 Year: Pages: 117 DOI: 10.3389/978-2-88945-331-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2018-02-27 16:16:45
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The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.

Myofilament Function in Health and Disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451869 Year: Pages: 161 DOI: 10.3389/978-2-88945-186-9 Language: English
Publisher: Frontiers Media SA
Subject: Physiology --- Science (General)
Added to DOAB on : 2017-08-28 14:01:09
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The present E-book, consisting of a compilation of original articles and reviews, presents how myofilaments are regulated in cardiac and skeletal muscles and trigger contraction. Additionally, this E-book gives insights into their dysregulation in a number of muscle disorders.

Keywords

Contraction --- Muscle --- Heart --- skeletal muscle --- sarcomere --- Myosin --- Actin --- Myopathy

Physiology in Extreme Conditions: Adaptations and Unexpected Reactions

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453382 Year: Pages: 133 DOI: 10.3389/978-2-88945-338-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2018-02-27 16:16:45
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Physiology in extreme conditions can reveal important reactions of the human body, which help our assessment of limits emerging under healthy conditions and critical signals of transition toward disease. While many mechanisms could simply be associated with adaptations, others refer to unexpected reactions in response to internal stimuli and/or external abrupt changes.

Ventricular Mechanics in Congenital Heart Disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452644 Year: Pages: 120 DOI: 10.3389/978-2-88945-264-4 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Pediatrics
Added to DOAB on : 2018-02-27 16:16:44
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Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.

Function of Renal Sympathetic Nerves

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452958 Year: Pages: 96 DOI: 10.3389/978-2-88945-295-8 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2018-02-27 16:16:44
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Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge.

In Search of In Vivo MSC

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452354 Year: Pages: 102 DOI: 10.3389/978-2-88945-235-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Biology
Added to DOAB on : 2017-10-13 14:57:01
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2017 (6)