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Grappling with the Multifaceted World of the DNA Damage Response

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450572 Year: Pages: 306 DOI: 10.3389/978-2-88945-057-2 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.

Publishing Addiction Science

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ISBN: 9781911529088 9781911529095 9781911529101 9781911529118 Year: Pages: 406 DOI: 10.5334/bbd Language: English
Publisher: Ubiquity Press
Subject: Biology --- Mathematics --- Medicine (General) --- Social Sciences --- Bibliography
Added to DOAB on : 2017-07-11 11:02:05
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"Publishing Addiction Science is a comprehensive guide for addiction scientists facing the complex process of contributing to scholarly journals. Written by an international group of addiction journal editors and their colleagues, it discusses how to write research articles and systematic reviews, choose a journal, respond to reviewers’ reports, become a reviewer, and resolve the often difficult authorship, ethical and citation issues that arise in addiction science publishing. As a “Guide for the Perplexed,” Publishing Addiction Science helps novice as well as experienced researchers to deal with these challenges. It is suitable for university courses and forms the basis of the training workshops offered by the International Society of Addiction Journal Editors (ISAJE).
Co-sponsored by ISAJE and the scientific journal Addiction, the third edition of Publishing Addiction Science gives special attention to the challenges faced by researchers from developing and non-English-speaking countries and features new chapters on guidance for clinician-scientists and the growth of infrastructure and career opportunities in addiction science."

Tales of Research Misconduct: A Lacanian Diagnostics of Integrity Challenges in Science Novels

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Book Series: Library of Ethics and Applied Philosophy ISSN: 1387-6678 / 2215-0323 ISBN: 9783319655536 9783319655543 Year: Pages: 263 DOI: https://doi.org/10.1007/978-3-319-65554-3 Language: English
Publisher: Springer
Subject: Philosophy
Added to DOAB on : 2017-11-24 16:09:15
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This monograph contributes to the scientific misconduct debate from an oblique perspective, by analysing seven novels devoted to this issue, namely: Arrowsmith by Sinclair Lewis (1925), The affair by C.P. Snow (1960), Cantor’s Dilemma by Carl Djerassi (1989), Perlmann’s Silence by Pascal Mercier (1995), Intuition by Allegra Goodman (2006), Solar by Ian McEwan (2010) and Derailment by Diederik Stapel (2012). Scientific misconduct, i.e. fabrication, falsification, plagiarism, but also other questionable research practices, have become a focus of concern for academic communities worldwide, but also for managers, funders and publishers of research. The aforementioned novels offer intriguing windows into integrity challenges emerging in contemporary research practices. They are analysed from a continental philosophical perspective, providing a stage where various voices, positions and modes of discourse are mutually exposed to one another, so that they critically address and question one another. They force us to start from the admission that we do not really know what misconduct is. Subsequently, by providing case histories of misconduct, they address integrity challenges not only in terms of individual deviance but also in terms of systemic crisis, due to current transformations in the ways in which knowledge is produced. Rather than functioning as moral vignettes, the author argues that misconduct novels challenge us to reconsider some of the basic conceptual building blocks of integrity discourse.

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