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Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450848 Year: Pages: 129 DOI: 10.3389/978-2-88945-084-8 Language: English
Publisher: Frontiers Media SA
Subject: Psychiatry --- Medicine (General)
Added to DOAB on : 2017-07-06 13:27:36
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Abstract

Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorders, as well as cardiovascular diseases, irritable bowel syndrome and pain syndromes, to name but a few, in vulnerable individuals. Although a number of pharmacological agents are available to treat such stress-related disorders, many patients do not respond to them, and those who do often report a number of side effects. Therefore, a major emphasis in modern basic research is to uncover the underlying aetiology of these disorders, and to develop novel efficacious treatment strategies. This has led to a resurgence in developing, and using, appropriate animal models to study a wide variety of stress-related disorders. Thus, the aim of this research topic “Using stress-based animal models to understand the mechanisms underlying psychiatric and somatic disorders” was to bring together novel research articles and comprehensive review articles from prominent stress researchers. In addition to describing the insights such models have provided relating to the aetiology of psychiatric and somatic disorders, these articles also encompass mechanisms that are believed to underlie stress resilience and stress-protection. Finally, given the current prominence on the role of the brain-gut axis in health and disease, the research topic covers the emerging evidence showing how the gut, particularly the microbiota, influences affective behaviour and physiology.

The Cognitive Neuroscience of Visual Working Memory

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451685 Year: Pages: 182 DOI: 10.3389/978-2-88945-168-5 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-08-28 14:01:09
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Visual working memory allows us to temporarily maintain and manipulate visual information in order to solve a task. The study of the brain mechanisms underlying this function began more than half a century ago, with Scoville and Milner’s (1957) seminal discoveries with amnesic patients. This timely collection of papers brings together diverse perspectives on the cognitive neuroscience of visual working memory from multiple fields that have traditionally been fairly disjointed: human neuroimaging, electrophysiological, behavioural and animal lesion studies, investigating both the developing and the adult brain.

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