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An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2

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ISBN: 9783038424130 9783038424123 Year: Pages: 320 DOI: 10.3390/books978-3-03842-413-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2017-07-12 07:57:21
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The 8th International Conference on Protein Kinase CK2 (www.uks.eu/ck2), organized by Matthias Montenarh and Claudia Götz, will be held at the Faculty of Medicine of Saarland University, in Homburg, Germany, from 6–9 September, 2016.Protein kinase CK2 is a serine/threonine kinase, which is highly conserved in evolution. Knock-out experiments have shown that this enzyme is absolutely necessary for cell viability. The enzyme is highly expressed in rapidly proliferating cells, which goes along with an elevated enzyme activity. Protein kinase CK2 is involved in a broad range of signaling pathways, regulating proliferation, differentiation, apoptosis, or senescence. Recent advances towards the characterization of the three-dimensional structure of protein kinase CK2 and its subunits will undoubtedly yield important new insights into its regulation, and the functions of CK2. Moreover, with two inhibitors of the enzyme presently in clinical phase II trials, human protein kinase CK2 has appeared as an emerging target for cancer diseases.

Wood in Civil Engineering

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ISBN: 9789535129851 9789535129868 9789535141075 Year: Pages: 250 DOI: 10.5772/63178 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 07:51:49

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Wood is a natural building material: if used in building elements, it can play structural, functional and aesthetic roles at the same time. The use of wood in buildings, which goes back to the oldest of times, is now experiencing a period of strong expansion in virtue of the sustainable dimension of wood buildings from the environmental, economic and social standpoints. However, its use as an engineering material calls for constant development of theoretical and experimental research to respond properly to the issues involved in this. In the single chapters written by experts in different fields, the book aims to contribute to knowledge in the application of wood in the building industry.

Proceedings of the 2nd Czech-China Scientific Conference 2016

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ISBN: 9789535128571 9789535128588 Year: Pages: 434 DOI: 10.5772/66773 Language: English
Publisher: IntechOpen
Subject: General and Civil Engineering
Added to DOAB on : 2019-10-03 09:47:10

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This book comprises the proceedings of the 2nd Czech-China Scientific Conference 2016 which was held on 7th June 2016 in Ostrava, Czech Republic. The objective of the conference was to present the latest achievements in the fields of advanced science and technology that stem from research activities of V

Growth, Structural Transformation, and Rural Change in Viet Nam: A Rising Dragon on the Move

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Book Series: WIDER Studies in Development Economics ISBN: 9780198796961 Year: Pages: 336 DOI: 10.1093/acprof:oso/9780198796961.001.0001 Language: English
Publisher: Oxford University Press Grant: UNU WIDER
Subject: Economics --- History --- Migration
Added to DOAB on : 2017-04-07 11:02:22
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Many developing countries—Viet Nam included—continue to struggle to raise incomes per capita. A common feature of the growth and development process is a fundamental change in the pattern of economic activity, as households reallocate labour from traditional agriculture to more productive forms of agriculture and modern industrial and service sectors. Broad structural transformation and widespread poverty reduction is the combined result of these large-scale shifts in work and labour allocation when they realize desired development goals. The roots of this book grow from when the first pilot Viet Nam Access to Resources Household Survey (VARHS) was carried out in 2002. The success of this inspired the Central Institute of Economic Management (CIEM) in Hanoi, the Institute of Policy and Strategy for Agriculture and Rural Development (CAP-IPSARD), the Institute of Labour Science and Social Affairs (ILSSA), and the Development Economics Research Group (DERG) of the University of Copenhagen, together with Danida and, later on, UNU-WIDER, to plan and carry out a more ambitious VARHS from 2006, increasing coverage and representativeness to more than 2,150 families and 12 provinces across the various regions of Viet Nam. The VARHS covering these very same households had, by 2014, been carried out five times, that is, every two years. It is on this high-quality panel data foundation and almost fifteen years of study and policy work using the VARHS data that the present volume builds, in its effort to bring out the essential rural microeconomic characteristics and insights of a dynamic South-East Asian economy in transition from a centrally planned towards a more market-based economy.

The Practice of Industrial Policy: Government—Business Coordination in Africa and East Asia

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ISBN: 9780198796954 Year: Pages: 336 DOI: 10.1093/acprof:oso/9780198796954.001.0001 Language: English
Publisher: Oxford University Press Grant: WIDER Studies in Development Economics
Subject: Economics
Added to DOAB on : 2017-04-27 11:01:30
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Much of the information relevant to policy formulation for industrial development is held by the private sector, not by public officials. There is, therefore, fairly broad agreement in the development literature that some form of structured engagement—often referred to as close or strategic coordination—between the public and private sectors is needed, to assist in the design of appropriate policies and provide feedback on their implementation. There is less agreement on how that engagement should be structured, how its objectives be defined, and how success be measured. In fact, the academic literature provides little practical guidance on how governments interested in developing such a framework should go about doing it. The burden of this lack of guidance falls most heavily on Africa, where—despite twenty years of growth—lack of structural transformation has slowed job creation and the pace of poverty reduction. In 2014, the Korea International Cooperation Agency (KOICA) and United Nations University World Institute for Development Economics Research (UNU-WIDER) launched a joint research project: The Practice of Industrial Policy. The aim is to help African policy makers develop better coordination between public and private sectors in order to identify the constraints to faster structural transformation and design, implement, and monitor policies to remove them. This book, written by national researchers and international experts, presents the results of that research by combining a set of analytical ‘framing’ essays on close coordination with case studies of successful and unsuccessful efforts at close coordination in Africa and in comparator countries.

Anatomy and Plasticity in Large-Scale Brain Models

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450657 Year: Pages: 173 DOI: 10.3389/978-2-88945-065-7 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)—an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)—an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.

The symbiosis between information system project complexity and information system project success

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ISBN: 9781928396253 Year: Pages: 184 DOI: 10.4102/aosis.2017.itpsc45 Language: English
Publisher: AOSIS Grant: University of Johannesburg
Subject: Computer Science
Added to DOAB on : 2018-02-21 11:01:44
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Project success is widely covered, and the discourse on project complexity is proliferating. The purpose of this book is to merge and investigate the two concepts within the context of information system (IS) projects and understand the symbiosis between success and complexity in these projects. In this original and innovative research, exploratory modelling is employed to identify the aspects that constitute the success and complexity of projects based on the perceptions of IS project participants. This scholarly book aims at deepening the academic discourse on the relationship between the success and complexity of projects and to guide IS project managers towards improved project performance through the complexity lens. The research methodology stems from the realisation that the complexity of IS projects and its relationship to project success are under-documented. A post positivistic approach is applied in order to accommodate the subjective interpretation of IS-project participants through a quantitative design. The researchers developed an online survey strategy regarding literature concerning the success and complexity of projects. The views of 617 participants are documented. In the book, descriptive statistics and exploratory factor analysis pave the way for identifying the key success and complexity constructs of IS projects. These constructs are used in structural-equation modelling to build various validated and predictive models. Knowledge concerning the success and complexity of projects is mostly generic with little exposure to the field of IS project management. The contribution to current knowledge includes how the success of IS projects should be considered as well as what the complexity constructs of IS projects are. The success of IS projects encompasses strategic success, deliverable success, process success and the ‘unknowns’ of project success. The complexity of IS projects embodies organisational complexity, environmental complexity, technical complexity, dynamics and uncertainty. These constructs of success and complexity are mapped according to their underlying latent relationships to each other. The intended audience of this book is fellow researchers and project and IS specialists, including information technology managers, executives, project managers, project team members, the project management office (PMO), general managers and executives that initiate and conduct project-related work. The work presented in this first edition of the book is original and has not been plagiarised or presented before. It is not a revised version of a thesis or research previously published. Comments resulted from the blind peer review process were carefully considered and incorporated accordingly.

Virtual Plants: Modeling Plant Architecture in Changing Environments

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450923 Year: Pages: 108 DOI: 10.3389/978-2-88945-092-3 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Plant architecture is a major determinant of the resource use efficiency of crops. The architecture of a plant shows ontogenetic structural changes which are modified by multiple environmental factors: Plant canopies are exposed to natural fluctuations in light quantity and the dynamically changing canopy architecture induces local variations in light quality. Changing temperature conditions or water availability during growth additionally affect plant architecture and thus crop productivity, because plants have various options to adapt their architecture to the available resources. Meeting the challenge of ensuring food security we must understand the plant’s mechanisms for integrating and responding to an orchestra of environmental factors. ‘Virtual plants’ describe plant architecture in silico. Virtual plants have the potential to help us understanding the complex feedback processes between canopy architecture, multiple environmental factors and crop productivity. As a research tool, they have become increasingly popular within the last decade due to their great power of realistically visualizing the plant’s architecture. This Research Topic highlights current research carried out on modeling plant architecture in changing environments.

Evaluation of Building Resilience Under Earthquake Input Using Single, Double and Multiple Impulses

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452705 Year: Pages: 61 DOI: 10.3389/978-2-88945-270-5 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2018-11-16 17:17:57
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This eBook is the third in a series of books on the critical earthquake response of elastic or elastic-plastic structures under near-fault or long-duration ground motions, and includes four original research papers which were published in the specialty section Earthquake Engineering in ‘Frontiers in Built Environment’. Several extensions of the first eBook and the second eBook are included here. The first article is on the earthquake resilience of residential houses after repeated ground motions with high intensity. The 2016 Kumamoto earthquake brought a significant impact on the earthquake resilience of residential houses under repeated ground motions with high intensity in a few days. The necessary strength upgrade withstanding two repeated high-intensity ground motions was found to be 1.5. The second article is concerned with the smart enhancement of earthquake resilience of building structures under both near-fault and long-duration ground motions. A hybrid system of base-isolation and building connection control was proposed and its earthquake resilience to near-fault and long-duration ground motions was evaluated by a double impulse and a multiple impulse. It was demonstrated that the base-isolation is effective for near-fault ground motions and the building connection system using passive dampers is effective for long-duration ground motions. The third article is related to the robustness evaluation of elastic-plastic base-isolated high-rise buildings under resonant near-fault ground motions. The robustness function was introduced to evaluate quantitatively the robustness of elastic-plastic base-isolated high-rise buildings. The fourth article is an extension of the previously proposed energy balance approach to a bilinear elastic-plastic single-degree-of-freedom system under a long-duration sinusoidal ground motion. A historical difficulty in nonlinear vibration posed by Caughey (1960) and Iwan (1961) has been overcome in a smart manner after half a century. The approach presented in this eBook, together with the previous eBooks, is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability and resilience of built environments in the elastic-plastic and nonlinear range.

Acoustic and Elastic Waves: Recent Trends in Science and Engineering

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ISBN: 9783038422976 9783038422969 Year: Pages: XVI, 448 DOI: 10.3390/books978-3-03842-297-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Mathematics --- Physics (General) --- Acoustics
Added to DOAB on : 2017-02-20 08:51:20
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The present Special Issue intends to explore new directions in the field of acoustics and ultrasonics. The interest includes, but is not limited to, the use of acoustic technology for condition monitoring of materials and structures.Topics of interest (among others):• Acoustic emission in materials and structures (without material limitation)• Innovative cases of ultrasonic inspection• Wave dispersion and waveguides• Monitoring of innovative materials• Seismic waves• Vibrations, damping and noise control• Combination of mechanical wave techniques with other types for structural health monitoring purposes.Experimental and numerical studies are welcome.

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