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Cytotoxicity

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ISBN: 9781789234305 9781789234312 Year: Pages: 278 DOI: 10.5772/intechopen.69919 Language: English
Publisher: IntechOpen
Subject: Public Health
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The book Cytotoxicity is aimed to be an essential reading to all medical students, biologists, biochemists and professionals involved in the field of toxicology. This book is a useful and ideal guide for novice researchers interested in learning research methods to study cytotoxic bioactive compounds. The parts of this book describe the replacement and different applications of the cytotoxic agents. All chapters are written by paramount experts in cytotoxicity research. This will hopefully stimulate more research initiatives, funding, and critical insight into the already increasing demand for cytotoxicity researches that have been evidenced worldwide.

Genotoxicity - A Predictable Risk to Our Actual World

Authors: ---
ISBN: 9781789234183 9781789234190 Year: Pages: 122 DOI: 10.5772/intechopen.69556 Language: English
Publisher: IntechOpen
Subject: Public Health
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This book is designed to provide an overview of the different genotoxicants and their effects on living organisms, including humans. The contributions made by the specialists in this field of research are gratefully acknowledged. We hope that the information presented in this book will meet the expectations and needs of all those interested in the different aspects of the genotoxicity field. The publication of this book is of great importance to those scientists, pharmacologists, physicians and veterinarians, as well as engineers, teachers, graduate students and administrators of environmental programmes, who make use of these investigations to understand both the basic and applied genotoxic aspects of known and new xenobiotics, and to guide them in their future investigations.

Botulinum Toxin

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ISBN: 9781789841350 9781789841367 Year: Pages: 154 DOI: 10.5772/intechopen.73809 Language: English
Publisher: IntechOpen
Subject: Public Health
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The aim of this book is to ensure a safe understanding and use of botulinum toxin in medicine. Known indications, contraindications, diversity, comparative effects between subtypes, limits, allergies, treatments, adverse reactions, nonresponsiveness, and new investigations will be described. Botulinum toxin can be currently used in nearly every specialty. The main areas in this book are cosmetics and dermatology, as well as dentistry, urology, masseter hypertrophy, chronic pain treatment, and others. The important aim is formation of the knowledge of anatomy, muscles to be treated and their function, risk factors, brand names, associations with operations, and other treatments.

Seizures

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ISBN: 9781789230048 9781789230055 Year: Pages: 184 DOI: 10.5772/65137 Language: English
Publisher: IntechOpen
Subject: Neurology --- Pediatrics
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This book contains selected peer-reviewed articles that cover novel information on epileptic seizure and psychogenic non-epileptic seizures written by international researchers. In this book, we discuss self-reporting technologies for supporting epilepsy treatment. We also discuss about the diagnostic testing in epilepsy genetic clinical practice. Clinical aspects related to diagnosis in patients presenting psychogenic non-epileptic seizures vs. epileptic seizures and neurocysticercosis are discussed as well. We delivered novel aspects about the treatment for pseudoseizures. In another chapter, the authors estimated the prevalence of ischemic stroke in epileptic patients presenting subarachnoid neurocysticercosis and ischemic stroke frequency among HIV-positive patients, and finally other authors discuss autoimmune epilepsy, its new development, and its future directions. We are looking forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.

Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors

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ISBN: 9781789231380 9781789231397 Year: Pages: 162 DOI: 10.5772/intechopen.68518 Language: English
Publisher: IntechOpen
Subject: Therapeutics
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This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Capsaicin and its Human Therapeutic Development

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ISBN: 9781789235203 9781789235210 Year: Pages: 124 DOI: 10.5772/intechopen.73124 Language: English
Publisher: IntechOpen
Subject: Therapeutics
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The enormous field of this topic is clearly shown by the following facts: during the last ten years (2007-2016) around 500 papers/ year and 523 review articles are listed in the PubMed database on capsaicin, and over 200/year are under keywords of ""capsaicin human"". Recently, two major studies on the mortality of consumers of spicy food containing capsaicin and nonconsumers (over 350000 men and women aged 30-79 with heart disease, cancer, and stroke at baseline over 3.5 million person-years, 2004-2013) showed that the relative risk in total mortality was reduced by 14% in 10 diverse geographic areas of China (2015). Similarly, in the USA, (16,179 participants during over 2,70,000 person/year with the median of 18.9 years) the total mortality was reduced by 13% in populations consuming hot chili (2017). Recently, the book series ""Progress in Drug Research"" the 68th volume dealt for the first time on ""Capsaicin as a Therapeutic Molecule"" (Springer, Basel, 2014). Five excellent chapters are found in this book dealing with procedures of capsaicin from capsicum plants, emerging technologies to improve capsaicin delivery, capsaicinoid diversity and its human food preference, capsaicin and lipid metabolism, and predictors in treatment response to capsaicin. The results of these observations clearly indicate that the capsaicin research has changed direction to include human medical treatment with capsaicin. The book gathers knowledge from experts in basic and clinical sciences, pharmacologists, in the nutrition and food industry, in the drug industry, technologists, plant cultivators, as well as experts across a wide scale of medical branches.

Molecular Insight of Drug Design

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ISBN: 9781789236323 9781789236330 Year: Pages: 130 DOI: 10.5772/intechopen.71744 Language: English
Publisher: IntechOpen
Subject: Therapeutics
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The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.

Anticoagulant Drugs

Author:
ISBN: 9781789236224 9781789236231 Year: Pages: 120 DOI: 10.5772/intechopen.70971 Language: English
Publisher: IntechOpen
Subject: Therapeutics
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Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.

Biopharmaceuticals

Authors: ---
ISBN: 9781789237184 9781789237191 Year: Pages: 138 DOI: 10.5772/intechopen.72960 Language: English
Publisher: IntechOpen
Subject: Pharmacy and materia medica
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Biopharmaceuticals are derived from biological sources, either live organisms or their active components; nowadays, they are mainly produced by biotechnologies. Biopharmaceuticals are extensively used in the treatment of various diseases such as cardiovascular, metabolic, neurological diseases, cancer, and others for which there are no available therapeutic methods. With the advance of science, biopharmaceuticals have revolutionized the treatment, prevention, and diagnosis of many patients with disabling and life-threatening diseases. Innovative biopharmaceuticals definitely improve the life quality of patients and enhance the effectiveness of the healthcare system. This book encompasses the discovery, production, application, and regulation of biopharmaceuticals to demonstrate their research achievement, prospects, and challenges. We expect the significance of biopharmaceuticals to be revealed and emphasized by this book.

Drug Discovery - Concepts to Market

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ISBN: 9781789236965 9781789236972 Year: Pages: 192 DOI: 10.5772/intechopen.70151 Language: English
Publisher: IntechOpen
Subject: Therapeutics
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The book ""Drug Discovery - Concepts to Market"" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the latest drug discovery trends that have been revolutionized with up-to-date technological developments. This book comprises single chapters authored by various researchers and edited by an expert active in the drug development research area. All chapters are independently complete but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts in this field from international authors and open new possible research paths for further novel developments.

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2018 (11)