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Dietary Zn and Human Health

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ISBN: 9783038970194 9783038970200 Year: Pages: XII, 216 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-07-10 13:50:52
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• Zinc (Zn) is an essential micronutrient that contributes to the proper functioning of over 300 enzymes and multiple biochemical and structural processes in the body. Zinc functions in the regulation of an extensive variety of genes, such as those involved in nucleic acid metabolism, cell signalling, apoptosis, and plays an integral role in immune system functioning. Even a mild Zn deficiency can profoundly affect growth and development, as well as impede immune differentiation and maturation. Zinc is widely distributed in foods, however, it was demonstrated that dietary constituents, such as phytate, polyphenols, and the intestinal microbiome, affect its dietary bioavailability and intestinal absorption. Regulation of zinc metabolism is achieved through a balance of absorption and excretion and involves adaptive mechanisms. The aim of this Special Issue is to explore dietary approaches that aim to improve Zn bioavailability and absorption, biomarkers of status, and the effect of Zn status on the intestinal microbiome.

Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456208 Year: Pages: 118 DOI: 10.3389/978-2-88945-620-8 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General)
Added to DOAB on : 2019-01-23 14:53:43
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It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification.In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.

Monitoring Pathophysiology in the Injured Brain

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454815 Year: Pages: 301 DOI: 10.3389/978-2-88945-481-5 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-01-23 14:53:42
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Pathophysiological processes in brain-injured patients can be assessed with an array of methods, with a goal to identify potentially deleterious events, guide treatments and avoid further deterioration. This eBook provides an in-depth exploration into different aspects of neuro-critical care monitoring and how new tools and strategies may be utilized to improve patient outcomes.

Bridging Music Informatics with Music Cognition

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455713 Year: Pages: 220 DOI: 10.3389/978-2-88945-571-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2019-01-23 14:53:43
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Music informatics is an interdisciplinary research area that encompasses data driven approaches to the analysis, generation, and retrieval of music. In the era of big data, two goals weigh heavily on many research agendas in this area: (a) the identification of better features and (b) the acquisition of better training data. To this end, researchers have started to incorporate findings and methods from music cognition, a related but historically distinct research area that is concerned with elucidating the underlying mental processes involved in music-related behavior.

Roles of NF-κB in Cancer and Their Therapeutic Approaches

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ISBN: 9783038971177 9783038971184 Year: Pages: X, 330 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Oncology --- Biology
Added to DOAB on : 2018-08-15 10:52:09
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Although mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity. NF-kB transcription factor family as emerged as such a promising target for cancer therapy. This Special Issue will explore the routes from NF-kB basic research, cancer research and oncogenomics into the development of NF-kB-based cancer therapeutics and biomarkers.We invite research and review papers in any area of the NF-kB field that are related, but not limited to, fundamental understanding of NF-kB signaling pathways, gene expression profiling, epigenetic regulation, diagnostic, prognostic and pharmacogenomic biomarkers, molecular targets driving the progression of human cancers, cancer drug development on these targets, clinical trial with new agents, and validation in animal models.We hope that this Special Issue reflects the exciting era that we are living in with respect to the field of NF-kB and its applications in cancer research.

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