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Data-Based Radiation Oncology - Design of Clinical Trials

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454389 Year: Pages: 109 DOI: 10.3389/978-2-88945-438-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2018-11-16 17:17:57
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In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients?Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable.In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management.

Biopesticides Manual Guidelines for Selecting, Sourcing, Producing and Using Biopesticides for Key Pests of Tobacco

Authors: --- --- --- --- et al.
ISBN: 9781789242010; 9781789242027 Year: Pages: 146 DOI: 10.1079/9781789242027.0000 Language: English
Publisher: CABI
Subject: Agriculture (General) --- Plant Sciences --- Ecology
Added to DOAB on : 2020-10-16 14:35:07
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This manual aims to make information resources and technical advice available in order to support the deployment of biopesticides, which include microbials (e.g. bacteria, algae, protozoa, viruses and fungi), macrobials (e.g. predatory insects, parasitoids and beneficial nematodes), botanicals, and semiochemicals. It is intended to be a one-stop shop to address the information needs of the key groups who are responsible for selecting, sourcing and using biopesticides in the tobacco production system. Chapter 2 provides information for decision makers to support selection of biopesticide active substances. It also provides guidelines for trial managers on experimental design, data collection and reporting. Chapter 3 provides guidance for sourcing biopesticides. It also includes manuals for the local production of three types of biopesticide: Trichogramma; neem [Azadirachta indica]; and fungal biopesticides such as Trichoderma. Chapter 4 presents training materials to provide an overview of biopesticides in general together with detailed information on how to work with the key biopesticides that have already been used successfully to manage key pests in tobacco.

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