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Nanofibres in Drug Delivery

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ISBN: 9781787350182 Year: Pages: 242 DOI: 10.14324/111.9781787350182 Language: English
Publisher: UCL Press
Subject: Medicine (General) --- Pharmacy and materia medica
Added to DOAB on : 2019-01-15 13:34:10
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In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory. The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.

Keywords

Nanofibres --- Drugs --- Drug delivery

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

Authors: ---
ISBN: 9783038427971 9783038427988 Year: Pages: VIII, 302 DOI: 10.3390/books978-3-03842-798-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-04-06 13:44:18
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Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population.This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.

Polymer Micelles

Authors: --- --- ---
ISBN: 9783038428077 9783038428084 Year: Pages: VIII, 220 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biochemistry
Added to DOAB on : 2018-04-20 15:30:28
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Classically, polymer micelles have been defined as aggregates formed by the self-association of amphiphilic polymers due to the hydrophobic interactions between polymer molecules in water. Practical applications of polymer micelles include as carriers in drug delivery systems, as solubilizers, and as associative thickeners. Polymer micelles that do not fall within the classical definition have recently been reported and reflect important developments in synthesis and analysis. For example, hydrophobic interactions are the classic force driving polymer association, whereas recently, micelles have been formed through interactions such as electrostatics, hydrogen bonds, and coordination bonds. Intermolecular association results in the formation of polymer micelles that are similar to micelles formed from low molecular weight surfactants, whereas unimolecular micelles formed by intramolecular association within a single polymer chain have also been reported, as have stimuli-responsive polymer micelles. It is therefore important to constantly update the information available and our knowledge of polymer micelles. This special issue covers synthesis, characterization, solution properties, association behavior, simulation, and the application of polymer micelles and polymer aggregates. The aim of this issue is to expand our knowledge of polymer micelles by gathering together the latest basic and applied information regarding these supramolecular structures.

Marine Polysaccharides Volume 3

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ISBN: 9783038429012 9783038429029 Year: Volume: 3 Pages: X, 564 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-04-24 09:32:36
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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Marine Polysaccharides Volume 2

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ISBN: 9783038428992 9783038429005 Year: Volume: 2 Pages: X, 290 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-04-24 09:35:54
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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Marine Polysaccharides Volume 1

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ISBN: 9783038428978 9783038428985 Year: Volume: 1 Pages: VIII, 224 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-04-24 09:38:37
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The field of marine polysaccharides is constantly evolving, due to progress in the discovery and production of new marine polysaccharides. Seaweed remains the most abundant source of polysaccharides, but recent advances in biotechnology have allowed the production of large quantities of polysaccharides from a variety of micro-algae, by controlling growth conditions and tailoring the production of bioactive compounds in a bioreactor. Of particular interest are polysaccharides produced by micro-organisms from extreme marine environments, due to their recognized different biochemistry. Extracellular polysaccharides (EPSs) with unique properties produced by a number of micro-algae are known. The first volume is a collection of papers concerning the identification and characterization of novel marine polysaccharides. It is divided into three chapters; the first two are dedicated to polysaccharides from different marine sources (algae, micro-algae, animals), while the third one gathers information on the isolation, characterization and bioactivity of new EPSs.

Selected Papers from 2017 International Conference on Micro/Nanomachines

Authors: ---
ISBN: 9783038970811 9783038970828 Year: Pages: VIII, 170 DOI: 10.3390/books978-3-03897-082-8 Language: english
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences --- Mechanical Engineering
Added to DOAB on : 2018-08-09 17:08:18
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The 2017 International Conference on Micro/Nanomachines (http://www.icmnm.org/) was held in Wuhan, China, 25–28 August, 2017. Micro/nanomotors (MNMs), which are defined as micro/nanodevices capable of converting energy into autonomous motion, can be used to pick up, transport, and release various cargoes within a liquid medium. They have important potential applications, for example, in drug delivery, biosensors, protein and cell separation, microsurgeries, and environment remediation. MNMs can be classified into two categories, according to their propulsion mechanism. In this respect, self-propelled MNMs are capable of moving autonomously without external intervention, but they either require toxic fuel or have a short lifespan. MNMs actuated by external fields, such as light, magnetic field, and acoustic waves, are not subject to these problems, do not require toxic fuels, nor give rise to by-products during the motion process. For both self-propelled and field-actuated MNMs, there is still a long way to go before we reach practical applications. The future development of MNMs should be focused on improving the energy conversion efficiency through structure optimization, exploring new propulsion mechanisms and endowing MNMs with environmental responses for self-navigation, detection, and specific operations. In this way, MNMs will approach their practical application in biomedicine, environment treatment, microengineering, etc.

Advances in Marine Chitin and Chitosan II, 2017

Authors: ---
ISBN: 9783038426776 9783038426783 Year: Pages: 410 DOI: 10.3390/books978-3-03842-678-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-01-16 09:37:31
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As a result of our call in 2014 for submissions to a Special Issue, Advances in Marine Chitin and Chitosan in Marine Drugs, we are now pleased to tell you that this issue has been published. Twenty high class papers were included in this issue, which we now plan to publish as a book. In addition we now seek to publish a further Special Issue, Advances in Marine Chitin and Chitosan II, 2017, in Marine Drugs. As before, we plan to produce a strong, very exciting issue that will encompass breakthroughs in high value, scientific and industrial chitin and chitosan research. Despite significant advances in chitin and chitosan research since the 1970s, current overviews in recent publications involving chitin and chitosan research advances need reporting.

Translocator Protein (TSPO)

Authors: ---
ISBN: 9783038427575 9783038427582 Year: Pages: 176 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-03-16 13:21:14
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The high number of papers submitted and ultimately accepted for publication in this special issue attests the great amount of research being conducted on TSPO and its role in living cells. Thus, TSPO has become an extremely attractive subcellular biomark for the early detection of disease states overexpressing this protein and for the selective delivery to mitochondria of drugs and probes. Moreover, the effort in the design and synthesis of new, more specific and effective TSPO ligands proves to be very valuable. All these topics have been addressed in the special issue.

Stimuli-Responsive Gels

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ISBN: 9783038972105 9783038972112 Year: Pages: 288 DOI: 10.3390/books978-3-03897-211-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Chemical Technology
Added to DOAB on : 2018-10-11 10:12:55
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Although the technological and scientific importance of functional polymers have been well established over the last few decades, the most recent focus that has attracted much attention concerns stimuli-responsive polymer gels. These materials are of particular interest due to their abilities to respond to internal and/or external chemo-physical stimuli. Aside from the scientific challenges of designing stimuli-responsive polymer gels, the main technological interests concern numerous applications, ranging from catalysis in microsystem technology and chemo-mechanical actuators to sensors. This Special Issue includes seventeen papers covering a wide range of subjects including thermo- and pH-responsive hydrogels, functionalized materials, supramolecular stimuli-responsive structures, composite hydrogels, sensors, and biomedical applications. Together, these contributions not only provide an excellent overview of the current state-of-the-art in the field but also point out exciting challenges and opportunities for future work. In a number of reviews the most recent findings on “Stimuli-Responsive Gels” are compiled in this book supplemented by original contributions.

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