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High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications

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ISBN: 9789535138655 9789535138662 9789535140450 Year: Pages: 174 DOI: 10.5772/intechopen.68268 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:51

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Dr. Ahmet Mesrur Halefoğlu mostly deals with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. He has served as postdoctoral research fellow at Johns Hopkins Hospital. Currently, he is working as an associate professor of radiology in Istanbul, Turkey. He has more than 50 high-impact-factor publications and has written 3 book chapters. He is a member of Turkish Society of Radiology and European Society of Radiology. During the recent years, there have been major breakthroughs in MRI due to developments in scanner technology and pulse sequencing. These important achievements have led to remarkable improvements in neuroimaging and advanced techniques, including diffusion imaging, diffusion tensor imaging, perfusion imaging, magnetic resonance spectroscopy, and functional MRI. These advanced neuroimaging techniques have enabled us to achieve invaluable insights into tissue microstructure, microvasculature, metabolism, and brain connectivity.

GABA And Glutamate - New Developments In Neurotransmission Research

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ISBN: 9789535138211 9789535138228 9789535140696 Year: Pages: 138 DOI: 10.5772/intechopen.68762 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:51

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This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Alzheimer's Disease - The 21st Century Challenge

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ISBN: 9781789234626 9781789234633 Year: Pages: 162 DOI: 10.5772/intechopen.71628 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:51

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Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

Prefrontal Cortex

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ISBN: 9781789239034 9781789239041 Year: Pages: 132 DOI: 10.5772/intechopen.73226 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:52

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The prefrontal cortex reaches its greatest development in the human brain, making up nearly one third of the neocortex. Due to its remarkable evolution, the prefrontal cortex plays an important role in higher integrative functions such as information processing, thinking, understanding, attention, behavior, motivation, emotions, working memory, and analysis. This book brings together theoretical and technical research advances on the prefrontal cortex, from the basic explanations of the neuronal architecture of the prefrontal cortex and its anatomy, presenting it as a morphological substrate for many psychological conditions, through normal and altered connectivity and its manifestation in different behavior and identification of organizational levels inside the prefrontal cortex through different neuroimaging methods. It also provides an interdisciplinary view of the prefrontal cortex and its issues and discovers the main role of this part of brain in psychosocial, economic, and cultural adaptation.

Cognitive and Computational Neuroscience - Principles, Algorithms and Applications

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ISBN: 9781789231885 9781789231892 Year: Pages: 104 DOI: 10.5772/intechopen.68377 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 09:47:13

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The book ""Cognitive and Computational Neuroscience - Principles, Algorithms and Applications"" will answer the following question and statements: System-level neural modeling: what and why? We know a lot about the brain! Need to integrate data: molecular/cellular/system levels. Complexity: need to abstract away higher-order principles. Models are tools to develop explicit theories, constrained by multiple levels (neural and behavioral). Key: models (should) make novel testable predictions on both neural and behavioral levels. Models are useful tools for guiding experiments. The hope is that the information provided in this book will trigger new researches that will help to connect basic neuroscience to clinical medicine.

Astrocyte - Physiology and Pathology

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ISBN: 9789535138853 9789535138860 9789535140771 Year: Pages: 242 DOI: 10.5772/intechopen.69076 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:51

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A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through ""gliotransmitters,"" ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.

Sex Hormones in Neurodegenerative Processes and Diseases

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ISBN: 9781789230147 9781789230154 Year: Pages: 358 DOI: 10.5772/66585 Language: English
Publisher: IntechOpen
Subject: Internal medicine
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The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Circadian Rhythm - Cellular and Molecular Mechanisms

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ISBN: 9781789233384 9781789233391 Year: Pages: 166 DOI: 10.5772/intechopen.71707 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:51

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Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.

Sensory Nervous System

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ISBN: 9781789233582 9781789233599 Year: Pages: 170 DOI: 10.5772/68128 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:51

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The sensory nervous system is of critical importance in our daily lives and contributes to our personal well-being and safety as well as communication with others. However, it is only when disease or injury impair its function that we fully appreciate the relevance of our sensory modalities. During the past decades, research of our senses has seen an ever-growing interest in this exciting field of study. This book provides the reader with an overview of the current state-of-the-art of research of our senses and focuses on the most important evidence-based developments in this area. This book addresses both the physiology and pathophysiology of our sensory nervous system ranging from molecular, cellular, and systems to cognitive and behavioral topics. Individual chapters focus on recent advances in specific areas of sensory systems in different model organisms and humans. All chapters represent recent contributions to the rapidly developing field of sensory science.

Autonomic Nervous System

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ISBN: 9781789841923 9781789841916 Year: Pages: 142 DOI: 10.5772/intechopen.73119 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:52

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The autonomic nervous system is one of the most important involuntary control mechanisms that primarily controls and modulates the functions of the visceral organs. The book discusses some of the specificities of the autonomic nervous system in terms of dendritic development in the sympathetic compartment, as well as a detailed description of noradrenergic groups and their key role in the modulation of all antinociceptive and autonomic responses elicited by painful or threatening situations. In the book, only those cases are mentioned that are closely related to disorders or changes of function of the autonomic nervous system. This book can evoke interest in many researchers who want to use the information for the advancement of their research towards a better understanding of the autonomic regulatory mechanisms.

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