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Cancer Survivorship

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ISBN: 9781789849066 9781789849073 Year: Pages: 140 DOI: 10.5772/intechopen.74342 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 07:51:52

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This book is a marvelous compendium of eight articles that cover a wide range of topics, including breast cancer: management and survivorship, rectal cancer intersphincteric resection, head and neck cancer diagnosis and radiotherapy, synthetic peptides as antitumor agents, and recent advances in thyroid cancer. It has been a wonderful opportunity to co-edit this special edition. We are greatly appreciative of the work of all the contributors to the book, who brought with them tremendous diversity of perspectives and fields truly reflective of the complexity of the topic and who, through coming together in this project, serve as a nidus of the multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies that have provided the information that has advanced the field so greatly in recent years.

Cell Culture

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ISBN: 9781789848663 9781789848670 Year: Pages: 292 DOI: 10.5772/intechopen.73709 Language: English
Publisher: IntechOpen
Subject: Cytology
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Cell culture is one of the major tools used in cellular and molecular biology, delivering an excellent model for studying the normal physiology and biochemistry of cells. This book covers some advanced aspects in cell culture methodologies. The book has four sections discussing different types of cell culture models, including 3D cell culture techniques, their advantages, and limitations in comparison to traditional 2D culturing; cell viability, autophagy, in vitro toxicity tests and live cell imaging; stem cell culture for cell-based therapeutics; and specific applications and methodologies for hybrid cell lines and cancer models. This book provides a comprehensive overview of some of the advanced cell culture methodologies and applications. It serves as a valuable source for scientists, researchers, clinicians and students.

Active Antimicrobial Food Packaging

Authors: ---
ISBN: 9781789850031 9781789850048 Year: Pages: 104 DOI: 10.5772/intechopen.74450 Language: English
Publisher: IntechOpen
Subject: Microbiology
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Active antimicrobial food packaging is a new generation of packaging. Antimicrobial food additives are incorporated in the food packaging systems to inhibit, retard, or inactivate microbial growth to extend the shelf life of foods. This book is composed of five chapters, and is aimed at introducing the reader to active antimicrobial food packaging, as well as concerns of the consumers on synthetic-based food additives.

Kinetics of Enzymatic Synthesis

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ISBN: 9781789850291 9781789850307 Year: Pages: 122 DOI: 10.5772/intechopen.76270 Language: English
Publisher: IntechOpen
Subject: Biochemistry
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Kinetics of Enzymatic Synthesis gives insight into different aspects of chemical reactions that are catalyzed by enzymes. This book is divided into two sections: ""Enzyme Kinetics"" and ""Enzymatic Synthesis"". The first section consists of two chapters with a halophilic enzyme kinetics and thermodynamic approach towards analyzing the influence of co-solvents on the Michaelis constants of enzyme-catalyzed reactions. The second section consists of three chapters. Production of isoamyl acetate using the enzymatic synthesis method between acetic anhydride and isoamyl alcohol by having enzyme Candida antarctica Lipase B as catalyst in a solvent-free system is discussed in the third chapter. The integrated scheme with the use of the filtrate from the pretreatment of the CS and the growth conditions of Pleurotus cystidiosus is studied in the fourth chapter. The last chapter of this section provides the conditions of the key parameters in microfluidic systems (residence times, flow rates, concentrations) applied for a sequential process from liquid/liquid extraction of LVV-h7.

Oncogenes and Carcinogenesis

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ISBN: 9781789851717 9781789851724 Year: Pages: 106 DOI: 10.5772/intechopen.74727 Language: English
Publisher: IntechOpen
Subject: Oncology
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Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.

In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders

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ISBN: 9781789857177 9781789857184 Year: Pages: 198 DOI: 10.5772/intechopen.72962 Language: English
Publisher: IntechOpen
Subject: Genetics
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Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis.

Biogenic Amines

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ISBN: 9781789841336 9781789841343 Year: Pages: 88 DOI: 10.5772/intechopen.75221 Language: English
Publisher: IntechOpen
Subject: Biology
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Biogenic amines (BAs) are low-molecular-mass organic bases that occur in plant- and animal-derived products. BAs in food can occur by free amino acid enzymatic decarboxylation and other metabolic processes. Usually, in the human body, amines contained in foods are quickly detoxified by enzymes such as amine oxidases or by conjugation; however, in allergic individuals or if monoamine oxidase inhibitors are applied, the detoxification process is disturbed and BAs accumulate in the body. Knowing the concentration of BAs is essential because they can affect human health and also because they can be used as freshness indicators to estimate the degree of food spoilage.

Staphylococcus Aureus

Authors: --- ---
ISBN: 9781789845921 9781789845938 Year: Pages: 144 DOI: 10.5772/intechopen.71376 Language: English
Publisher: IntechOpen
Subject: Animal Sciences --- Microbiology
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Staphylococcus aureus strains are an important medical infectious agent that causes a wide range of pathogeneses starting from colonization of the skin and mucosal surface to severe pathogenic effects such as septicemia. The mortality and morbidity from this pathogen are challenging issues for the healthcare premises. Methicillin Resistant Staphylococcus aureus strains (MRSA) are causing severe infections due to the genes that are resistant to several antibiotics including methicillin, aminoglycosides, and others. Recently, there have been several reports related to failure of treatment plans caused by MRSA that led to Vancomycin Intermediate Staphylococcus aureus strains (VISA) or, in sporadic cases, resistance to the drug of choice. This book highlights the new areas for the treatment of MRSA using natural products. The implementation of specific products produced by this organism can help the scientist to obtain a new window for treatments such as anticancer chemotherapy, antioxidants, etc.

Autoantibodies and Cytokines

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ISBN: 9781789848526 9781789848533 Year: Pages: 216 DOI: 10.5772/intechopen.68834 Language: English
Publisher: IntechOpen
Subject: Microbiology
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The mechanism of autoantibodies cannot be explained without the detail knowledge of cytokines and interferon. These active molecules of immunology are very much dependent on each other and their function cannot be completed without their interaction towards each other. Currently, this the most updated book on this subject that helps the readers/students to upgrade their knowledge by going through chapter by chapter. Contribution by the renounced authors across the globe makes this book really unique and consider as one of the most updated textbook on this subject. This book provides a comprehensive guide to the function and types of autoantibodies and cytokines in basic and clinical field.

Cell Signalling - Thermodynamics and Molecular Control

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ISBN: 9781838800659 9781838800666 Year: Pages: 84 DOI: 10.5772/intechopen.73411 Language: English
Publisher: IntechOpen
Subject: Cytology
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Intracellular signal transduction is an important topic of research in cell and molecular biology. It has a wide range of implications in growth, differentiation, development, animal polarity, cellular response monitoring, and many disease processes, including cancer. The functional homeostasis of a cell is assumed to be maintained by an intricate network of signaling that evolved through natural selection. This book includes chapters written in the frontier areas of research on cell signaling. Issues such as information thermodynamics, master regulation of immune tolerance, genetically encoded reporter circuits and their applications, hypoxia, and vitamin K2 mediated signaling processes are addressed and discussed by eminent researchers of the field.

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