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Biomaterial-supported Tissue Reconstruction or Regeneration

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ISBN: 9781838803773 9781838803780 9781838804336 Year: Pages: 162 DOI: 10.5772/intechopen.77756 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:53

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This book is a collection of chapters from different biomaterial experts, including their design, new insights into the molecular basis of their interaction with the organism, and their successful application. The chapters have been organized to illustrate different aspects of multidisciplinary biomaterial science. Thus, this book should give readers a view into the different biomaterial disciplines and methodologies that are needed for specific clinical applications.

Cartilage Tissue Engineering and Regeneration Techniques

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ISBN: 9781789238495 9781789238501 9781838807818 Year: Pages: 158 DOI: 10.5772/intechopen.77717 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:53

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Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Dilated Cardiomyopathy

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ISBN: 9783030138646 Year: Pages: 241 DOI: 10.1007/978-3-030-13864-6 Language: English
Publisher: Springer Nature
Subject: Medicine (General) --- Biology
Added to DOAB on : 2020-02-05 11:21:10
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This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Bioengineering Liver Transplantation

Authors: --- ---
ISBN: 9783039217441 9783039217458 Year: Pages: 132 DOI: 10.3390/books978-3-03921-745-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.

Stem Cell and Biologic Scaffold Engineering

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ISBN: 9783039214976 9783039214983 Year: Pages: 110 DOI: 10.3390/books978-3-03921-498-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.

Processing-Structure-Properties Relationships in Polymers

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ISBN: 9783039218806 9783039218813 Year: Pages: 400 DOI: 10.3390/books978-3-03921-881-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-01-07 09:08:26
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This collection of research and review papers is aimed at depicting the state of the art on the possible correlations between processing variables, obtained structure and special properties which this structure induces on the plastic part. The extraordinary capacity of plastics to modify their properties according to a particular structure is evidenced for several transformation processes and for many applications. The final common goal is to take profit of this peculiar capacity of plastics by inducing, through a suitable processing, a specific spatial organization.

Keywords

carbon nanotube --- homogeneous dispersion --- ethylene vinyl acetate --- mechanical performance --- electrical conductivity --- microencapsulation --- melamine polyphosphate --- polyurethane --- composite --- flame retardant --- biodegradable nanofibers --- PLGA --- collagen --- epinephrine --- lidocaine --- polyimide film --- linear coefficient of thermal expansion (CTE) --- copper clad laminate --- structure and properties --- polymorphism --- isotactic polypropylene --- deformation --- phase transitions --- uniaxial compression --- uniaxial tensile deformation --- temperature --- in situ X-ray --- cavitation --- indentation --- Harmonix AFM --- polymer morphology --- mechanical properties --- ultra-high molecular weight polyethylene (UHMWPE) --- microcellular injection molding --- supercritical fluid --- supercritical N2 --- supercritical CO2 --- tissue engineering and regenerative medicine --- bioresorbable polymers --- 3D printing/additive manufacturing --- fused filament fabrication/fused deposition modelling --- degradation --- physicochemical characterization --- polycaprolactone --- layered double hydroxides --- ionic liquids --- PLA --- reactive blending --- biobased films --- graphene --- nanoreinforcement --- curing rate --- epoxy microstructure --- fatigue --- composites --- critical gel --- poly(lactic acid) --- carbon black --- graphite --- polymer blend --- poly(ethylene terephthalate) --- intrinsic viscosity --- polyolefin --- compatibilizer --- isotactic polypropylene --- stress-induced phase transitions --- structural analysis --- X-ray diffraction --- polyoxymethylene (POM) --- octakis[(3-glycidoxypropyl)dimethylsiloxy]octasilsesquioxane (GPOSS) --- composites --- morphology --- mechanical properties --- conductive filler --- orientation --- conductive polymer composites --- foam --- model --- PLLA --- bioresorbable vascular scaffolds --- stretch blow molding --- biaxial elongation --- SAXS --- WAXS --- microfibrillar composites --- crystalline morphology --- crystallinity --- mechanical properties --- crystallisation --- morphology --- nanoparticles --- shear --- flow --- orientation --- poly(?-caprolactone) --- polyvinyl butyral --- hydrophobicity --- contact angle --- polypropylene --- atomic force microscopy --- injection molding --- mold temperature evolution --- polycaprolactone --- ultra-high molecular weight polyethylene --- incremental forming --- SPIF --- XRD --- chain orientation --- temperature sensitive --- gel --- controllable gas permeability --- breathable film --- polymer composite --- processing --- polyamide 6 --- compression molding --- polymorphism --- polyamide 6 --- injection molding --- polymorphism --- humidity --- mechanical properties

Blood-Derived Products for Tissue Repair/Regeneration

Authors: ---
ISBN: 9783039218608 9783039218615 Year: Pages: 178 DOI: 10.3390/books978-3-03921-861-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:08:26
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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

Keywords

platelets --- burns --- growth factors --- platelet rich plasma --- quantification --- articular cartilage --- cartilage repair --- redifferentiation --- collagen hydrogels --- biologics --- hyperacute serum --- platelet-rich plasma --- fibrosis --- myoblasts --- myofibroblasts --- myogenesis --- Platelet-Rich Plasma (PRP) --- Platelet-Poor Plasma (PPP) --- satellite cells --- skeletal muscle regeneration --- stem cell niche --- regenerative medicine --- hyperacute serum --- platelet-rich plasma --- blood derived products --- composition --- meniscus --- meniscus repair --- meniscus tear --- trephination --- platelet-rich plasma --- PRP --- chronic meniscal lesion --- horizontal meniscal tear --- periosteal sheet --- platelet-rich fibrin --- growth --- differentiation --- bone grafting material --- PRGF --- Carprofen --- dog --- fracture --- bone healing --- wrist osteoarthritis --- microfat --- platelet-rich plasma --- cell therapy --- adipose tissue --- PRP --- knee arthrosis --- growth factors --- autologous platelet concentrates --- bone defects --- bone grafting --- bone regeneration --- furcation defects --- periodontal defects --- periodontal regeneration --- periodontal surgery --- platelet-rich plasma --- platelet-rich fibrin --- plasma rich in growth factors --- tissue healing --- corneal epithelial defect --- cornea regeneration --- serum eye drops --- plasma rich plasma (PRP) --- serum derived from plasma rich in growth factors (s-PRGF) --- hyaluronic acid (NaHA) --- wound healing --- bone regeneration --- bone repair --- fibrin sealant --- biomaterial --- photobiomodulation therapy --- low-level laser therapy --- n/a

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