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This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on “Metal Complex Interactions with Nucleic Acids and/or DNA”. This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the field of metal complex interactions with nucleic acids and/or DNA. Moreover, this Special Issue on "Metal Complexes Interactions with Nucleic Acids and/or DNA" provides an overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity.
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Why is it that some ways of using English are considered "good" and others are considered "bad"? Why are certain forms of language termed elegant, eloquent or refined, whereas others are deemed uneducated, coarse, or inappropriate? Making Sense of "Bad English" is an accessible introduction to attitudes and ideologies towards the use of English in different settings around the world. Outlining how perceptions about what constitutes "good" and "bad" English have been shaped, this book shows how these principles are based on social factors rather than linguistic issues and highlights some of the real-life consequences of these perceptions.
African-American English --- Bad and Good English --- English language systems --- English with an Accent --- Language Attitudes to English --- Language Ideologies --- New Delhi English --- Singlish --- real-life social parallels
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During the past four decades or so, various operators of fractional calculus, such as those named after Riemann–Liouville, Weyl, Hadamard, Grunwald–Letnikov, Riesz, Erdelyi–Kober, Liouville–Caputo, and so on, have been found to be remarkably popular and important due mainly to their demonstrated applications in numerous diverse and widespread fields of the mathematical, physical, chemical, engineering, and statistical sciences. Many of these fractional calculus operators provide several potentially useful tools for solving differential, integral, differintegral, and integro-differential equations, together with the fractional-calculus analogues and extensions of each of these equations, and various other problems involving special functions of mathematical physics, as well as their extensions and generalizations in one and more variables. In this Special Issue, we invite and welcome review, expository, and original research articles dealing with the recent advances in the theory of fractional calculus and its multidisciplinary applications.
operators of fractional calculus --- chaos and fractional dynamics --- fractional differential --- fractional differintegral equations --- fractional integro-differential equations --- fractional integrals --- fractional derivatives associated with special functions of mathematical physics --- applied mathematics --- identities and inequalities involving fractional integrals --- fractional derivatives
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Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD.
OCD --- tDCS --- brain stimulation --- neuromodulation --- obsession --- compulsion --- depression --- olfaction --- markers --- quality of life --- therapeutic tool --- transcranial direct current stimulation --- depression --- cognition --- m-health --- i-health --- depression --- nosography --- categorizations --- symptoms networks --- ecological momentary assessment --- ecological momentary intervention --- fictional case study --- psychiatry --- OCD --- obsessive–compulsive disorder --- Tourette syndrome --- immunology --- cytokines --- pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS) --- pediatric acute-onset neuropsychiatric syndrome (PANS) --- Toxoplasma gondii --- Streptococcus pyogenes --- n/a
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Climate change is one of the main threats to modern society. This phenomenon is associated with an increase in greenhouse gas (GHGs, mainly carbon dioxide—CO2) emissions due to anthropogenic activities. The main causes are the burning of fossil fuels and land use change (deforestation). Climate change impacts are associated with risks to basic needs (health, food security, and clean water), as well as risks to development (jobs, economic growth, and the cost of living). The processes involving CO2 capture and storage are gaining attention in the scientific community as an alternative for decreasing CO2 emissions, reducing its concentration in ambient air. The carbon capture and storage (CCS) methodologies comprise three steps: CO2 capture, CO2 transportation, and CO2 storage. Despite the high research activity within this topic, several technological, economic, and environmental issues as well as safety problems remain to be solved, such as the following needs: increase of CO2 capture efficiency, reduction of process costs, and verification of the environmental sustainability of CO2 storage.
CO2 separation --- TBAB --- IGCC --- anti-agglomerant --- micromorphology --- hydrate --- carbon capture and storage --- knowledge mapping --- technological evolution --- CiteSpace --- carbon storage --- the Loess Plateau --- InVEST --- carbon density --- normalized difference vegetation index (NDVI) --- supercritical CO2 --- flow instability --- stability map --- CO2 pipeline --- carbon capture and storage (CCS) --- CO2 capture and utilization --- energy dependence --- power-to-methane --- synthetic natural gas --- renewable power --- fossil fuels --- electricity production --- carbon capture --- calcium looping --- life cycle assessment --- GHG mitigation --- CCS --- cement --- techno-economic analysis --- MEA-based absorption --- chilled ammonia --- membrane-assisted CO2 liquefaction --- oxyfuel --- calcium looping --- CO2 capture --- cement production with CO2 capture --- CO2 capture in industry --- CO2 capture retrofitability --- oxyfuel --- chilled ammonia --- membrane-assisted CO2 liquefaction --- calcium looping
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This book will provide the most recent knowledge and advances in Sample Preparation Techniques for Separation Science. Everyone working in a laboratory must be familiar with the basis of these technologies, and they often involve elaborate and time-consuming procedures that can take up to 80% of the total analysis time. Sample preparation is an essential step in most of the analytical methods for environmental and biomedical analysis, since the target analytes are often not detected in their in-situ forms, or the results are distorted by interfering species. In the past decade, modern sample preparation techniques have aimed to comply with green analytical chemistry principles, leading to simplification, miniaturization, easy manipulation of the analytical devices, low costs, strong reduction or absence of toxic organic solvents, as well as low sample volume requirements.Modern Sample Preparation Approaches for Separation Science also provides an invaluable reference tool for analytical chemists in the chemical, biological, pharmaceutical, environmental, and forensic sciences.
vitamins --- extraction --- determination --- review --- sample preparation --- matrix solid phase dispersion --- sorbent --- miniaturization --- on-line --- blueberry --- non-anthocyanin polyphenol --- vortex-assisted dispersive liquid-liquid microextraction --- response surface methodology --- desirability function approach --- nail --- curie temperature --- high-frequency heating --- liquid chromatography–tandem mass spectrometry --- caffeine --- amlodipine --- gas chromatography --- hydrogel --- hormones --- pectin --- polyvinyl alcohol --- sample preparation --- in-tube SPME --- UHPLC-MS/MS --- organic-based monoliths --- antipsychotics --- plasma samples --- schizophrenic’ patients --- salting-out assisted liquid–liquid extraction --- sugaring-out assisted liquid–liquid extraction --- hydrophobic-solvent assisted liquid–liquid extraction --- subzero-temperature assisted liquid–liquid extraction --- phenolic compounds --- sorbent-based techniques --- multi-spheres adsorptive micro-extraction (MSA?E) --- floating sampling technology --- caffeine and acetaminophen tracers --- environmental water matrices --- vortex-assisted dispersive liquid-liquid microextraction --- China herbal tea --- pesticides residue --- aflatoxins --- UPLC-MS/MS --- vortex-synchronized matrix solid-phase dispersion --- crab shells --- ionic liquids --- anthraquinones --- Cassiae Semen --- sample preparation --- nanocomposite --- pathogenic --- enrichment --- nucleic acid isolation --- sample preparation with TLC/HPTLC --- solvent front position extraction --- solvent delivery with a moving pipette --- automation --- LC–MS/MS --- environmental analysis --- whole water --- trace analysis --- SPE --- large volume --- in-line filter --- sand --- flow rate --- pharmaceuticals --- hormones --- pesticides --- space instrumentation --- liquid chromatography --- oligopeptides --- trapping system --- membrane-based microextraction --- barbiturates --- simultaneous determination --- whole blood --- urine --- liver --- sample preparation --- oxylipins --- protein precipitation --- liquid–liquid extraction --- solid-phase extraction --- biological samples --- chlorophenoxy acid herbicides --- HPLC --- hydrophobic in-tube solid-phase microextraction --- poly (OMA-co-TRIM) monolithic column --- rice grains --- gold --- sample preparation --- preconcentration --- geological samples
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Due to the influence of pore-throat size distribution, pore connectivity, and microscale fractures, the transport, distribution, and residual saturation of fluids in porous media are difficult to characterize. Petrophysical methods in natural porous media have attracted great attention in a variety of fields, especially in the oil and gas industry. A wide range of research studies have been conducted on the characterization of porous media covers and multiphase flow therein. Reliable approaches for characterizing microstructure and multiphase flow in porous media are crucial in many fields, including the characterization of residual water or oil in hydrocarbon reservoirs and the long-term storage of supercritical CO2 in geological formations. This book gathers together 15 recent works to emphasize fundamental innovations in the field and novel applications of petrophysics in unconventional reservoirs, including experimental studies, numerical modeling (fractal approach), and multiphase flow modeling/simulations. The relevant stakeholders of this book are authorities and service companies working in the petroleum, subsurface water resources, air and water pollution, environmental, and biomaterial sectors.
Wilkins equation --- non-laminar flow --- turbulence modelling --- porous media --- oil tanker --- temperature drop --- oscillating motion --- numerical simulation --- soil-water characteristic curve --- initial void ratio --- air-entry value --- fractal dimension --- fractal model --- oil properties --- diffusion coefficient --- supercritical CO2 --- Peng-Robinson equation of state (PR EOS) --- CT --- digital rock --- microfractures --- Lattice Boltzmann method --- pore-scale simulations --- tight sandstone --- pore structure --- multifractal --- classification --- Ordos Basin --- loose media --- coal --- porosity --- true density --- bulk density --- overburden pressure --- particle size --- tight conglomerate --- fracture characterization and prediction --- fractal method --- salt rock --- creep --- damage --- fractional derivative --- acoustic emission --- marine gas hydrate --- submarine landslide --- greenhouse gas emission --- lifecycle management --- hazard prevention --- multilayer reservoir --- interlayer interference --- producing degree --- seepage resistance --- wellbore multiphase flow --- inclined angle --- liquid rate --- gas rate --- pressure drawdown model with new coefficients --- base-level cycle --- pore structure --- mouth bar sand body --- Huanghua Depression --- isotopic composition --- methane --- gas hydrate --- South China Sea --- Bakken Formation --- pore structure --- controlling factors --- low-temperature nitrogen adsorption --- petrophysics --- fractal porous media --- unconventional reservoirs --- multiphase flow
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The interest in the topic of spirituality as a more or less independent dimension of quality of life is continuously growing, and research questions are beginning to change as the field of religiosity changes, becoming more diverse and pluralistic. Addressing new topics in health research also relies on standardized questionnaires. The number of instruments intended to measure specific aspects of spirituality is growing, and it is particularly difficult to evaluate the new instruments. This Special Issue will focus on some of the established instruments (updating them to different languages and cultures), but will also describe the features and intentions of newly-developed instruments, which may potentially be used in larger studies to develop knowledge relevant to spiritual care and practice. This Special Issue will serve as a resource on the instruments used to study the wide range of organized religiosity, the individual experience of the divine, and an open approach in the search for meaning and purpose in life.
spirituality --- Franciscan --- validation --- questionnaire --- Christian religious practices --- Catholics --- engagement frequency --- validation --- questionnaire --- spiritual needs --- questionnaire --- factorial structure --- validation --- structural equation modeling --- patients --- chronic disease --- healthy persons --- elderly --- spirituality --- spiritual well-being --- religiosity --- religious beliefs --- clinical setting --- evaluation --- measurement --- scoping review --- attitudes towards religion --- Filipino students --- religiosity --- spirituality --- self-report measure of religion --- moral injury --- internal conflict --- post-traumatic stress disorder --- veterans --- active duty military --- Attachment to God Inventory --- IAD-Br --- styles of attachment --- attachment theory --- Validation --- Brazil --- awe --- gratitude --- spirituality --- validation --- questionnaire --- psychometric properties --- transcultural adaptation --- spiritual needs --- people living with HIV --- spirituality --- spiritual well-being --- translation --- validation --- SHALOM --- Lithuania --- spiritual jihad --- Islam --- Muslims --- struggles --- growth --- spiritual needs --- translation --- exploratory factor analysis --- internal consistency --- n/a
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The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
hippo pathway --- YAP/TAZ --- prostate cancer --- castration resistance --- signal cross-talk --- feedback loops --- Hippo pathway --- innate immunity --- adaptive immunity --- cancer immunity --- autoimmunity --- YAP (yes-associated protein) --- TAZ (transcriptional co-activator with PDZ-binding motif) --- LATS (large tumor suppressor kinase) --- MST (mammalian STE20-like protein kinase) --- Hippo pathway --- cancer --- angiogenesis --- vascular mimicry --- YAP --- TAZ --- MST1/2 --- LATS1/2 --- Hippo signalling --- skin development --- stem cells --- skin cancer --- fibroblasts --- fibrosis --- wound healing --- G protein-coupled receptor --- GPCR --- Hippo pathway --- YAP/TAZ --- signal transduction --- cancer --- tumorigenesis --- anti-cancer therapy --- YAP --- TAZ --- MST1/2 --- LATS1/2 --- myofibroblast --- ECM --- fibrosis --- EMT --- cancer --- chromatin --- epigenetic --- transcription --- Hippo pathway --- Mps one binder --- Hippo pathway --- protein kinase --- signal transduction --- phosphorylation --- protein-protein interactions --- structure biology --- STK38 --- NDR --- LATS --- MST --- STRIPAK --- TEAD --- Hippo pathway --- cancer --- stem cell --- Lats2 --- Hippo --- Yap --- Taz --- peripheral nerve sheath tumor --- schwannoma --- zebrafish --- n/a
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The present book contains 14 papers published in the Special Issue “Differential Geometry” of the journal Mathematics. They represent a selection of the 30 submissions. This book covers a variety of both classical and modern topics in differential geometry. We mention properties of both rectifying and affine curves, the geometry of hypersurfaces, angles in Minkowski planes, Euclidean submanifolds, differential operators and harmonic forms on Riemannian manifolds, complex manifolds, contact manifolds (in particular, Sasakian and trans-Sasakian manifolds), curvature invariants, and statistical manifolds and their submanifolds (in particular, Hessian manifolds). We wish to mention that among the authors, there are both well-known geometers and young researchers. The authors are from countries with a tradition in differential geometry: Belgium, China, Greece, Japan, Korea, Poland, Romania, Spain, Turkey, and United States of America. Many of these papers were already cited by other researchers in their articles. This book is useful for specialists in differential geometry, operator theory, physics, and information geometry as well as graduate students in mathematics.
Euclidean submanifold --- position vector field --- concurrent vector field --- concircular vector field --- rectifying submanifold --- T-submanifolds --- constant ratio submanifolds --- Ricci soliton --- Kähler–Einstein metrics --- compact complex surfaces --- pinching of the curvatures --- statistical manifolds --- Hessian manifolds --- Hessian sectional curvature --- scalar curvature --- Ricci curvature --- Minkowski plane --- Minkowskian length --- Minkowskian angle --- Minkowskian pseudo-angle --- L2-harmonic forms --- Hodge–Laplacian --- manifold with singularity --- L2-Stokes theorem --- capacity --- k-th generalized Tanaka–Webster connection --- non-flat complex space form --- real hypersurface --- lie derivative --- shape operator --- conical surface --- developable surface --- generalized 1-type Gauss map --- cylindrical hypersurface --- inextensible flow --- lightlike surface --- ruled surface --- Darboux frame --- C-Bochner tensor --- generalized normalized ?-Casorati curvature --- Sasakian manifold --- slant --- invariant --- anti-invariant --- trans-Sasakian 3-manifold --- Reeb flow symmetry --- Ricci operator --- Sasakian statistical manifold --- conjugate connection --- Casorati curvature --- framed rectifying curves --- singular points --- framed helices --- centrodes --- circular rectifying curves --- statistical structure --- affine hypersurface --- affine sphere --- conjugate symmetric statistical structure --- sectional ?-curvature --- complete connection --- symplectic curves --- circular helices --- symplectic curvatures --- Frenet frame
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