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Natural Compounds as New Cancer Treatments

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ISBN: 9783039213658 9783039213665 Year: Pages: 128 DOI: 10.3390/books978-3-03921-366-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:15
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Cancer remains one of the main causes of morbidity and mortality worldwide. Although many pharmacological and clinical advances have been made, there is a constant need for new molecules to improve the overall options for treatment. Natural compounds from animal, microbial, vegetal, or fungal origin represent countless sources of new compounds that can be used as anticancer drugs, provided their activity, bioavailability, and toxicity are adequate. This book aims to compile both original articles and reviews that cover the most recent advances in the use of natural compounds for cancer treatment, and provide new objectives and advice for future research in the field of biological activity of natural compounds.

Physical Metallurgy of High Manganese Steels

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ISBN: 9783039218561 9783039218578 Year: Pages: 212 DOI: 10.3390/books978-3-03921-857-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Mining and Metallurgy
Added to DOAB on : 2020-01-07 09:08:26
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The Special Issue ‘Physical Metallurgy of High Manganese Steels’ addresses the highly fascinating class of manganese-alloyed steels with manganese contents well above 3 mass%. The book gathers manuscripts from internationally recognized researchers with stimulating new ideas and original results. It consists of fifteen original research papers. Seven contributions focus on steels with manganese contents above 12 mass%. These contributions cover fundamental aspects of process-microstrcuture-properties relationships with processes ranging from cold and warm rolling over deep rolling to heat treatment. Novel findings regarding the fatigue and fracture behavior, deformation mechanisms, and computer-aided design are presented. Additionally, the Special Issue also reflects the current trend of reduced Mn content (3-12 mass%) in advanced high strength steels (AHSS). Eight contributions were dedicated to these alloys, which are often referred to as 3rd generation AHSS, medium manganese steels or quenching and partitioning (Q&P/Q+P) steels. The interplay between advanced processing, mainly novel annealing variants, and microstructure evolution has been addressed using computational and experimental approaches. A deeper understanding of strain-rate sensitivity, hydrogen embrittlement, phase transformations, and the consequences for the materials’ properties has been developed. Hence, the topics included are manifold, fundamental-science oriented and, at the same time, relevant to industrial application.

Keywords

medium-manganese steel --- TRIP --- strain-rate sensitivity --- Lüders band --- serrated flow --- in-situ DIC tensile tests --- TWIP steel --- deformation twinning --- serrated flow --- dynamic strain aging --- damage --- fracture --- medium-manganese --- forging --- austenite reversion --- mechanical properties --- microstructure --- D&amp --- P steel --- processing --- microstructure --- phase transformation --- dislocation density --- mechanical properties --- MMn steel X20CrNiMnVN18-5-10 --- V alloying --- corrosion resistance --- precipitations --- ultrafine grains --- high-manganese steels --- high-entropy alloys --- alloy design --- plastic deformation --- annealing --- microstructure --- texture --- mechanical properties --- neutron diffraction --- austenite stability --- medium manganese steel --- double soaking --- localized deformation --- medium-Mn steel --- hot-stamping --- double soaking --- continuous annealing --- quenching and partitioning --- high strength steel --- high manganese steel --- crash box --- lightweight --- multiscale simulation --- high-Mn steels --- twinning induced plasticity --- cold rolling --- recrystallization annealing --- grain refinement --- strengthening --- austenitic high nitrogen steel (HNS) --- cold deformation --- fatigue --- high manganese steel --- warm rolling --- processing --- microstructure --- texture --- mechanical properties --- deformation behavior --- high-manganese steel --- deep rolling --- TWIP --- TRIP --- near surface properties --- residual stresses --- fatigue behavior --- intercritical annealing --- medium manganese steel --- phase field simulation --- medium-Mn steel --- austenite-reversed-transformation --- retained austenite --- hydrogen embrittlement --- ultrafine-grained microstructure --- strain-hardening behavior --- n/a

Colloids and Interfaces in Oil Recovery

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ISBN: 9783039211067 9783039211074 Year: Pages: 234 DOI: 10.3390/books978-3-03921-107-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2019-06-26 08:44:06
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It is well-known that colloid and interface science and petroleum production are inextricably linked. Whether in the reservoir, with its porous structure, or during recovery, crude oil is intimately associated with rock surfaces and with water, often in the form of emulsions. This situation leads to highly complex systems, comprising multiple colloids and interfaces, which require to be optimized if oil is to be recovered efficiently, both in terms of economic cost and with due concern for the environment. This book contains a compilation of contemporary research topics which illustrate various aspects of the importance of colloids and interfaces in crude oil recovery through modifying conditions between the rock, crude oil, and water in the reservoir, in order to achieve improved oil recovery. The specific topics covered relate both to conventional oils, in which waterflooding is the most common secondary and tertiary means of recovery, and to non-conventional heavy oil and natural bitumen, which require thermal recovery methods, owing to their high viscosity.

Marine Natural Products and Obesity

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ISBN: 9783039211913 9783039211920 Year: Pages: 194 DOI: 10.3390/books978-3-03921-192-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

Natural Stone and Architectural Heritage

Authors: --- ---
ISBN: 9783039215508 9783039215515 Year: Pages: 262 DOI: 10.3390/books978-3-03921-551-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-12-09 11:49:15
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This book is made up of contributions dealing with heritage stones from different countries around the world. The stones are described, as well as their use in vernacular and contemporaneous architecture. Heritage stones are those stones that have special significance in human culture. Examples include some very important stones that have been either neglected because they are no longer extracted, or stones that have great significance in commercial terms but knowledge of their national and/or international heritage has not been well documented. In this collection of articles, we have tried to spread awareness of architectural heritage around the world, the natural stones that have been used in its construction, and the need to preserve historical quarries that once provided the source of such stones. Historical quarries are linked to regional culture and tradition. Because of the specific technical and aesthetical characteristics of heritage stones, which have lasted for centuries, these historical quarries should be preserved to be able to use the stones for the proper restoration of monuments and historical buildings to avoid negative actions that can be observed in many places in the restoration of buildings, which are some times part of World Heritage sites. The final intention of this book is to continuosly grow the interest on this fascinating subject of heritage stones.

Keywords

Gyeongju Historic Areas --- 2016 Gyeongju Earthquake --- site characterisation --- site-specific ground response analysis --- stone architectural heritage --- dynamic centrifuge test --- Cheomseongdae --- ancient seismic design technique --- serpentinites --- rocks characterization --- dimension stone --- architectural heritage --- pyroclastic rock --- dimension stone --- Sardinia --- geoheritage --- market --- houses based on natural stone --- architectural heritage --- the bay of Kotor --- UNESCO cultural heritage --- Studenica --- Sopo?ani --- marble deposits --- quarry characterisation --- restoration --- sustainability --- management --- cultural heritage conservation --- sustainability --- architectural conservation --- stone architecture heritage --- modern principles of double-layered ventilated roofs --- conservation requirements --- UNESCO World Heritage List --- marble --- wettability properties --- hydrophobicity --- laser surface texturing --- multiscale roughness --- cultural heritage --- ultrafast pulse laser --- dolostone --- quarries --- Coimbra Formation --- heritage --- Chianocco marble --- heritage stone --- archaeometry --- Western Alps --- isotopic analysis --- SEM-EDS --- heritage stone --- quartzite --- Bargiolina --- quarries --- dimension stone --- kaolin --- industrial minerals --- natural stone --- fracturing pattern --- quarrying --- geoheritage --- Unesco World Heritage Site --- building stones --- Guadeloupe --- Martinique --- French West Indies --- eastern Caribbean --- cultural heritage --- geological heritage --- historical and Archaeological sites --- Candoglia marble --- Duomo di Milano --- petrographic analysis --- geoheritage --- cultural stone

Novel Non-Precious Metal Electrocatalysts for Oxygen Electrode Reactions

Authors: --- ---
ISBN: 9783039215409 9783039215416 Year: Pages: 190 DOI: 10.3390/books978-3-03921-541-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-12-09 11:49:16
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Research on alternative energy harvesting technologies, conversion and storage systems with high efficiency, cost-effective and environmentally friendly systems, such as fuel cells, rechargeable metal-air batteries, unitized regenerative cells, and water electrolyzers has been stimulated by the global demand on energy. The conversion between oxygen and water plays a key step in the development of oxygen electrodes: oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), processes activated mostly by precious metals, like platinum. Their scarcity, their prohibitive cost, and declining activity greatly hamper large-scale applications. This issue reports on novel non-precious metal electrocatalysts based on the innovative design in chemical compositions, structure, and morphology, and supports for the oxygen reaction.

Fractional Differential Equations: Theory, Methods and Applications

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ISBN: 9783039217328 9783039217335 Year: Pages: 172 DOI: 10.3390/books978-3-03921-733-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-12-09 11:49:16
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Fractional calculus provides the possibility of introducing integrals and derivatives of an arbitrary order in the mathematical modelling of physical processes, and it has become a relevant subject with applications to various fields, such as anomalous diffusion, propagation in different media, and propogation in relation to materials with different properties. However, many aspects from theoretical and practical points of view have still to be developed in relation to models based on fractional operators. This Special Issue is related to new developments on different aspects of fractional differential equations, both from a theoretical point of view and in terms of applications in different fields such as physics, chemistry, or control theory, for instance. The topics of the Issue include fractional calculus, the mathematical analysis of the properties of the solutions to fractional equations, the extension of classical approaches, or applications of fractional equations to several fields.

DNA Replication Stress

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ISBN: 9783039213894 9783039213900 Year: Pages: 368 DOI: 10.3390/books978-3-03921-390-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 16:10:12
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This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.

Keywords

barley --- chromosome --- DNA replication pattern --- EdU --- mutagens --- DNA replication --- DNA damage --- DNA repair --- genome integrity --- A549 cells --- H1299 cells --- heterogeneity --- DNA damage response --- 8-chloro-adenosine --- DNA replication --- S phase --- origin firing --- TopBP1 --- ATR --- DNA fiber assay --- APE2 --- ATR-Chk1 DDR pathway --- Genome integrity --- SSB end resection --- SSB repair --- SSB signaling --- DNA replication stress --- genome stability --- ubiquitin --- replication fork restart --- translesion synthesis --- template-switching --- homologous recombination --- Fanconi Anemia --- G protein-coupled receptor (GPCR) --- aging --- DNA damage --- ?-arrestin --- G protein-coupled receptor kinase (GRK) --- interactome --- G protein-coupled receptor kinase interacting protein 2 (GIT2) --- ataxia telangiectasia mutated (ATM) --- clock proteins --- energy metabolism --- neurodegeneration --- cellular senescence --- ageing --- Alzheimer’s disease --- multiple sclerosis --- Parkinson’s disease --- lipofuscin --- SenTraGorTM (GL13) --- senolytics --- DNA replication --- DNA repair --- DNA damage response --- DNA translocation --- DNA helicase --- superfamily 2 ATPase --- replication restart --- fork reversal --- fork regression --- chromatin remodeler --- C9orf72 --- ALS --- motor neuron disease --- R loops, nucleolar stress --- neurodegeneration --- Difficult-to-Replicate Sequences --- replication stress --- non-B DNA --- Polymerase eta --- Polymerase kappa --- genome instability --- common fragile sites --- Microsatellites --- cancer --- DNA double-strand repair --- premature aging --- post-translational modification --- protein stability --- replication stress --- Werner Syndrome --- Werner Syndrome Protein --- dormant origins --- replicative stress --- replication timing --- DNA damage --- genome instability --- cancer --- Thermococcus eurythermalis --- endonuclease IV --- AP site analogue --- spacer --- DNA repair --- DNA repair --- double strand break repair --- exonuclease 1 --- EXO1 --- mismatch repair --- MMR --- NER --- nucleotide excision repair --- strand displacements --- TLS --- translesion DNA synthesis --- POL? --- mutation frequency --- mutations spectra --- SupF --- mutagenicity --- oxidative stress --- DNA damage --- DNA repair --- replication --- 8-oxoG --- epigenetic --- gene expression --- helicase --- cell cycle checkpoints --- genomic instability --- G2-arrest --- cell death --- repair of DNA damage --- adaptation --- n/a

Nutrition and Vulnerable Groups

Authors: ---
ISBN: 9783039211203 9783039211210 Year: Pages: 264 DOI: 10.3390/books978-3-03921-121-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-06-26 08:44:06
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Food insecurity is a complex ‘wicked’ problem that results from a range of unstable and uncertain physical, social, cultural and economic factors that limits access to nutritious food. Globally, 800 million people are under-nourished, and around 2 billion are overweight/obese or have micronutrient deficiency. These populations are largely positioned in developing countries where disease burden is high and impacts health budgets and productivity. Similarly developed countries, cities and neighbourhoods are experiencing a greater emergence of vulnerable populations. This is in part explained by the change in the food production and manufacturing, the retraction in economic climates, the increase in food price, and in some regions reduced food availability and access.Vulnerable groups include but are not limited to migrant populations, Indigenous people, elderly, pregnant women, those with disability, homeless, young children and youth. Poor nutrition at significant periods of growth and development and during life impact long term health outcomes increasing non-communicable disease prevalence, health cost and reducing economic productivity.

Keywords

breastfeeding --- feeding practices --- infant feeding --- nutrition --- malnutrition --- pediatrics --- primary health care --- low-income population --- popular restaurant --- lunch --- energy density --- nutrition --- food security --- HFIAS --- double burden of malnutrition --- child stunting --- Indonesia --- emergency food assistance --- food pantry --- food insecurity --- dietary patterns --- dietary quality --- nutrition --- knowledge --- refugees --- children --- school intervention --- Lebanon --- rural populations --- food assistance --- low-income --- vulnerable groups --- food poverty --- food insecurity --- food literacy --- public health --- socioeconomics --- Obesity --- metabolic syndrome --- refugee --- women --- Palestine --- consumption of fruits and vegetables --- low-income undergraduate students --- Student Assistance Program --- adiposity markers --- obesity --- fat mass --- abdominal obesity --- adolescent health --- school performance --- Orang Asli --- food insecurity --- Malaysia --- challenges --- in-depth interview --- fruit and vegetables --- rural children --- Social Cognitive Theory --- undernutrition --- food security --- nutrition security --- village chickens --- livestock --- animal-source food --- Tanzania --- sub-Saharan Africa --- resource-poor settings --- children --- welfare home --- body image --- obesity --- BMI-for-age --- food security --- self-esteem --- self-efficacy --- food security --- public health --- place-based --- co-design --- vulnerable groups --- food poverty --- food insecurity --- food literacy --- public health --- charitable food sector --- food insecurity --- food literacy --- nutrition education --- training --- tertiary education --- n/a

Mycoviruses

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ISBN: 9783038979968 9783038979975 Year: Pages: 350 DOI: 10.3390/books978-3-03897-997-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2019-06-26 08:44:06
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A virus (from the Latin word ‘v?rus’ meaning ‘venom’ or ‘poison’) is a microorganism invisible to the naked eye. Viruses can multiply exclusively by entering a cell and using the cell’s resources to create copies of themselves. As the origin of their name suggests, viruses are generally considered dangerous, harmful and often deadly. Some of the most well-studied and widely known viruses, such as HIV and influenza, infect humans. However, viruses can also infect animals, plants and microorganisms, including fungi. Many fungi are medically, ecologically and economically significant, for example, causing diseases to humans, plants and insects or being used in industry to produce bread, cheese, beer and wine. Viruses that infect fungi are called mycoviruses (from the Greek work ‘myco’, meaning ‘fungus’). Mycoviruses do not cause harm to or kill the infected fungus; in contrast, they are ‘friendly’ viruses and we can utilize them to control the growth, pathogenicity and toxin production of fungi. This book describes a range of different mycoviruses and their geographical distribution, transmission and evolution, together with their effects on the fungal hosts and how these are brought about.

Keywords

RNA silencing --- gemycircularvirus --- mycovirus --- antiviral --- dicer --- dsRNA mycoviruses --- multiplex PCR --- Aspergillus fumigatus chrysovirus --- Aspergillus fumigatus partitivirus-1 --- Aspergillus fumigatus tetramycovirus-1. --- Botrytis cinerea --- hypovirus --- fusarivirus --- hypovirulence --- infection cushion --- Botrytis cinerea --- Botrytis cinerea mymonavirus 1 --- Mymonaviridae --- dsRNA virus --- mycovirus --- capsid protein --- capsid structure --- virus evolution --- viral lineage --- ScV-L-A --- PcV --- PsV-F --- RnQV1 --- chrysovirus --- mycovirus --- Aspergillus --- A. fumigatus --- A. nidulans --- A. niger --- A. thermomutatus --- biocontrol --- Saccharomyces paradoxus --- Totiviridae --- dsRNA virus --- killer system --- Trichoderma atroviride --- Mycovirus --- Partitivirus --- Fusarium head blight --- mycovirus --- RNA genome --- mitovirus --- Tymovirales --- Ethiopia --- Sclerotinia minor --- endornavirus --- hypovirulence --- transmissibility --- biological control --- Chalara fraxinea --- Hymenoscyphus pseudoalbidus --- ash dieback --- Narnaviridae --- evolution --- invasive species --- horizontal virus transmission --- Brunchorstia pinea --- conifers --- mycovirus --- dsRNA --- ssRNA --- phylogeny --- evolution --- mycovirus --- Beauveria bassiana --- partitivirus --- victorivirus --- polymycovirus --- selection pressure --- recombination --- transmission --- mycovirus --- populations study --- Cryphonectria parasitica --- chestnut blight --- Castanea sativa --- biological control --- Mycovirus --- rice blast fungus --- Magnaporthe oryzae. chrysovirus 1 --- double-stranded RNA virus --- hypovirulence --- Rhizoctonia solani AG-1 IA --- mycovirus --- dsRNA --- Alphapartitivirus --- genomic structure analysis --- mycorrhizal fungi --- mycovirus --- mitovirus --- Rhizophagus --- hypovirus --- small RNA --- tRFs --- mycovirus --- fungal viruses --- dsRNA mycoviruses --- hypervirulence --- Leptosphaeria biglobosa quadrivirus --- Botrytis cinerea --- hypovirulence --- partitivirus --- conidiogenesis --- sclerogenesis --- mycovirus --- dsRNA --- sequencing --- killer toxin --- totivirus --- brown rot --- stone fruit --- Prunus --- mycovirus --- hypervirulence --- hypovirulence --- isogenic --- database mining --- Entomophthora --- Entomophthoromycotina --- fungal virus --- mitochondrion --- mycovirus --- virus discovery --- Mitovirus --- Narnaviridae --- n/a

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