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Fundamentals of Clinical Data Science

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ISBN: 9783319997131 Year: Pages: 219 DOI: 10.1007/978-3-319-99713-1 Language: English
Publisher: Springer Nature
Subject: Medicine (General) --- Biology
Added to DOAB on : 2020-02-05 11:21:13
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This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.

Exploring Resilience

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Book Series: SpringerBriefs in Applied Sciences and Technology ISBN: 9783030031893 Year: Pages: 128 DOI: 10.1007/978-3-030-03189-3 Language: English
Publisher: Springer Nature
Subject: Economics --- Sociology --- Medicine (General) --- Environmental Sciences --- Agriculture (General)
Added to DOAB on : 2020-02-04 11:21:12
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Resilience has become an important topic on the safety research agenda and in organizational practice. Most empirical work on resilience has been descriptive, identifying characteristics of work and organizing activity which allow organizations to cope with unexpected situations. Fewer studies have developed testable models and theories that can be used to support interventions aiming to increase resilience and improve safety. In addition, the absent integration of different system levels from individuals, teams, organizations, regulatory bodies, and policy level in theory and practice imply that mechanisms through which resilience is linked across complex systems are not yet well understood. Scientific efforts have been made to develop constructs and models that present relationships; however, these cannot be characterized as sufficient for theory building. There is a need for taking a broader look at resilience practices as a foundation for developing a theoretical framework that can help improve safety in complex systems. This book does not advocate for one definition or one field of research when talking about resilience; it does not assume that the use of resilience concepts is necessarily positive for safety. We encourage a broad approach, seeking inspiration across different scientific and practical domains for the purpose of further developing resilience at a theoretical and an operational level of relevance for different high-risk industries. The aim of the book is twofold: 1. To explore different approaches for operationalization of resilience across scientific disciplines and system levels. 2. To create a theoretical foundation for a resilience framework across scientific disciplines and system levels. By presenting chapters from leading international authors representing different research disciplines and practical fields we develop suggestions and inspiration for the research community and practitioners in high-risk industries. This book is Open Access under a CC-BY licence. ; Explores different approaches for operationalization of resilience across scientific disciplines and system levels Creates a theoretical foundation for a resilience framework across scientific disciplines and system levels Develops suggestions and inspiration for the research community and practitioners in high-risk industries Presents chapters from leading international authors representing different research disciplines and practical fields

Health and Wellbeing in Late Life

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ISBN: 9789811389382 Year: Pages: 195 DOI: 10.1007/978-981-13-8938-2 Language: English
Publisher: Springer Nature
Subject: Social Sciences --- Public Health --- Medicine (General)
Added to DOAB on : 2020-02-04 11:21:23
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This open access book takes a multidisciplinary approach to provide a holistic understanding of late old age, and situates the aged person within the context of family, caregivers, clinical and other institutions. All through the book, the author discusses preparedness for an aging individual as well as the society in the Indian context. The book highlights inevitable but mostly neglected health issues like depression, dementia, fall, and frailty and provides detailed analyses of solutions that are practicable in low resource settings. It also brings up intergenerational differences and harmony in the context of holistic care of older Indians. Alongside clinical perspectives, the book uses narratives of elderly patients to dwell on the myriad of problems and issues that constitute old age healthcare. Demonstrating cases that range from the most influential to the most underprivileged elderly in India, the book enlightens multiple caregivers—doctors, nurses, and professional caregivers as well as family members—about the dynamic approach required in dealing with complex issues related to late old age. The narratives make the book relatable and interesting to non-academic readers, with important lessons for gerontological and geriatric caregiving. It is also of use to older adults in preparing for active aging.

Psychiatry and Decolonisation in Uganda

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ISBN: 9781137600943 Year: DOI: 10.1057/978-1-137-60095-0 Language: English
Publisher: Springer Nature
Subject: Social Sciences --- History --- Psychiatry
Added to DOAB on : 2019-10-19 11:21:22
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This open access book investigates psychiatry in Uganda during the years of decolonisation. It examines the challenges facing a new generation of psychiatrists as they took over responsibility for psychiatry at the end of empire, and explores the ways psychiatric practices were tied to shifting political and development priorities, periods of instability, and a broader context of transnational and international exchange. At its heart is a question that has concerned psychiatrists globally since the mid-twentieth century: how to bridge the social and cultural gap between psychiatry and its patients? Bringing together archival research with oral histories, Yolana Pringle traces how this question came to dominate both national and international discussions on mental health care reform, including at the World Health Organization, and helped spur a culture of experimentation and creativity globally. As Pringle shows, however, the history of psychiatry during the years of decolonisation remained one of marginality, and ultimately, in the context of war and violence, the decolonisation of psychiatry was incomplete.

Buruli Ulcer

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ISBN: 9783030111144 Year: Pages: 287 DOI: 10.1007/978-3-030-11114-4 Language: English
Publisher: Springer Nature
Subject: Public Health --- Internal medicine --- Medicine (General)
Added to DOAB on : 2020-02-05 11:21:11
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A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans. ; Supports further investigation by summarizing state of the art in the field of Buruli ulcer research Enriches understanding of epidemiology of Buruli ulcer in different geographic regions Reviews exhaustively the characteristics of Mycobacterium ulcerans disease

Biodiversity and Health in the Face of Climate Change

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ISBN: 9783030023188 Year: Pages: 481 DOI: 10.1007/978-3-030-02318-8 Language: English
Publisher: Springer Nature
Subject: Public Health --- Medicine (General) --- Environmental Sciences --- Geology --- Earth Sciences
Added to DOAB on : 2020-02-05 11:21:12
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This open access book identifies and discusses biodiversity’s contribution to physical, mental and spiritual health and wellbeing. Furthermore, the book identifies the implications of this relationship for nature conservation, public health, landscape architecture and urban planning – and considers the opportunities of nature-based solutions for climate change adaptation. This transdisciplinary book will attract a wide audience interested in biodiversity, ecology, resource management, public health, psychology, urban planning, and landscape architecture. The emphasis is on multiple human health benefits from biodiversity - in particular with respect to the increasing challenge of climate change. This makes the book unique to other books that focus either on biodiversity and physical health or natural environments and mental wellbeing. The book is written as a definitive ‘go-to’ book for those who are new to the field of biodiversity and health.

P-type ATPases in Health and Disease

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889457113 Year: Pages: 256 DOI: 10.3389/978-2-88945-711-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:43
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P-type ATPases are a large group of evolutionary related ion and lipid pumps that have in common that they catalyze a transient phosphorylated intermediate at a key conserved aspartate residue within the pump in order to function. While all the P-type ATPases perform active transport across cellular membranes, they have different transport specificities and serve diverse physiological functions. The ion pumps of the P-type ATPase family create electrochemical gradients that are essential for transepithelial transport, nutrient uptake and membrane potential. They mediate cellular signaling and provide the ligands for metalloenzymes. Phospholipid flippases, also members of the P-type ATPase superfamily, regulate the asymmetric lipid distribution across the lipid bilayer and are critical for the biogenesis of cell membranes. Since all of these ATPases serve fundamental cellular functions, malfunctioning is associated with various pathophysiological processes and dysfunctions of P-type ATPases are known to contribute to cardiovascular, neurological, renal and metabolic diseases. However, with the ever growing knowledge about the diseases associated with the malfunction of P-type ATPases, they are also promising targets for future drug development. In eukaryotes the most prominent examples of P-type ATPases are the Na+,K+-ATPase (sodium pump), the H+-ATPase (proton pump), the H+,K+-ATPase (proton-potassium pump) and the Ca2+-ATPases (calcium pumps). Mutations in the alpha2 and alpha3 subunit of Na,K-ATPase have been associated with neurological diseases, including rapid-onset dystonia-parkinsonism, familial hemiplegic migraine and alternating hemiplegia of childhood. Dysregulation and loss of expression of Na,K-ATPase and plasma membrane Ca-ATPases may be involved in cancer progression. Malfunctioning of the Ca-ATPases is also thought to contribute to hypertension and neurodegenerative diseases and mutations can cause cardiac dysfunction, deafness, hypertension and cerebellar ataxia. Mutations in the SERCA calcium pumps can cause heart failure, Brody myopathy and Darier disease and mutations in the Cu-ATPase genes cause Menkes and Wilson disease. Deficiencies in phospholipid flippases have been linked to progressive familial intrahepatic cholestasis, obesity, diabetes, hearing loss and neurological diseases.

Organisasjonsperspektiv på samordning av helse- og velferdstjenester

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ISBN: 9788202631833 Year: Pages: 219 DOI: 10.23865/noasp.66 Language: Norwegian
Publisher: Cappelen Damm Akademisk/NOASP (Nordic Open Access Scholarly Publishing)
Subject: Sociology --- Social and Public Welfare
Added to DOAB on : 2019-07-03 11:21:10
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"The book discusses various challenges and solutions related to the coordination of health and welfare services. Coordination is central to creating integrated services for users with complex needs. In order to understand the challenges and opportunities associated with creating such services, one needs knowledge related to organizations and the organizational context. The book's chapters takes on an organizational perspective where patterns and explanations are sought in formal and informal structures, processes and culture. The users’ need for services often cross established boundaries, both organizational and professional. The authors highlight the possibilities and limitations of some selected solutions that will help to cut across or break down such boundaries. Examples of such solutions are user involvement, interdisciplinary collaboration, team organizations, coordinators, standardization and patient pathways, digitization and decision-making tools for employees who work in the services. One chapter summarizes three different theoretical research approaches for analyzing coordination and collaboration. The target group is researchers, university and college employees and students of the health and welfare sector. The book also will be of interest for user organizations as well as administrative and professional decision-makers in public and private businesses."

The Pathologisation of Homosexuality in Fascist Italy

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ISBN: 9783030009939 Year: DOI: 10.1007/978-3-030-00994-6 Language: English
Publisher: Springer Nature
Subject: Languages and Literatures --- Social Sciences --- Sociology --- Psychology --- Political Science
Added to DOAB on : 2019-10-19 11:21:22
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This open access book investigates the pathologisation of homosexuality during the fascist regime in Italy through an analysis of the case of G., a man with "homosexual tendencies" interned in the Collegno mental health hospital in 1928. No systematic study exists on the possibility that Fascism used internment in an asylum as a tool of repression for LGBT people, as an alternative to confinement on an island, prison or home arrests. This research offers evidence that in some cases it did. The book highlights how the dictatorship operated in a low-key, shadowy and undetectable manner, bending pre-existing legislation. Its brutality was - and still is - difficult to prove. It also emphasises the ways in which existing stereotypes on homosexuality were reinforced by the regime propaganda in support of its so-called moralising campaign and how families, the police and the medical professionals joined forces in implementing this form of repression.

Non-Communicable Disease Prevention: Best Buys, Wasted Buys and Contestable Buys

Authors: --- --- ---
ISBN: 9781783748631 9781783748655 Year: Pages: 220 DOI: 10.11647/OBP.0195 Language: English
Publisher: Open Book Publishers
Subject: Medicine (General)
Added to DOAB on : 2019-12-13 14:55:14
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Non-communicable diseases (NCDs) are the leading cause of death worldwide, contributing to over 73% of all deaths annually. Each day NCDs cause more than 100,000 deaths, 80% of which occur in low- and middle-income countries. NCDs, however, are largely preventable, and a great deal of technical knowledge exists about how to prevent and manage them. Why, then, have we, as a global community, not been more successful at reducing this NCD burden? Does a universal problem not have a universal solution?Created by an international consortium of experts, this informative and accessible book provides practical guidelines, key learning points, and dynamic, real-world case studies to aid NCD program managers, policy officers and decision-makers in low- and middle-income countries, so that they can assess interventions for the prevention and control of NCDs.The book was commissioned by the Prince Mahidol Award Conference (PMAC), an annual international conference centred on policy of global significance related to public health. Non-Communicable Disease Prevention: Best Buys, Wasted Buys and Contestable Buys emphasises the importance of context in NCD control and prevention, arguing that the success of an intervention lies in an ability to respond to local needs and environments. The book comprises ten chapters, which collectively explore the reasons behind, and strategies for, preventing and managing the NCD burden. It spans key themes such as political economy, the transferability of economic evidence, the role of cross-sectoral policies, the importance of deliberative processes, and health technology assessment.This book is written for the benefit of the global health community, and is primarily targeted at those individuals who are involved in NCD programs. This book will also be of interest to NCD champions, policy advocates, and educators spearheading the movement for increased visiblity of NCDs.

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